Multiple Quantum MRS

Eliav, Uzi

doi:10.1002/9780470034590.emrstm1448

Cited by 1 publication

(3 citation statements)

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“…MQF NMR is applied for the identification of various compartments (Eliav et al 2012) (e.g., it could be the extracellular matrix and myelin in nerves and brain), for observation of the changes of the collagen fibers in cartilage during maturation and changes of cartilage obtained from osteoarthritic and osteoporotic patients, and the monitoring of healing of injured tendons (Seo et al 1999;Eliav and Navon 2016). MQF is able also to measure the changes in the intracellular sodium pool in ischemic hearts.…”

Section: Mqf Nmr In Studying Anisotropic Mobilitymentioning

confidence: 99%

“…They demonstrated a good correlation of this ratio with [Na] i measured at elevated sodium concentration and in the case with shift reagent. However, some questions still exist because MQF signals could be observed even in saline solutions in the absence of biological tissues (Eliav and Navon 2016). The formation of the 2nd rank tensor prevails over the 3rd rank one.…”

Section: Mqf Nmr In Studying Anisotropic Mobilitymentioning

confidence: 99%

“…The formation of the 2nd rank tensor prevails over the 3rd rank one. This does mean that in the presence of paramagnetic shift reagents, MQF signals may not provide reliable information about the ratio of MQF signals between the intra-and extracellular compartments (Eliav and Navon 2016).…”

Section: Mqf Nmr In Studying Anisotropic Mobilitymentioning

confidence: 99%

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NMR techniques in studying water in biotechnological systems

Rodin

2020

Biophys Rev

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Different NMR methodologies have been considered in studying water as a part of the structure of heterogeneous biosystems. The current work mostly describes NMR techniques to investigate slow translational dynamics of molecules affecting anisotropic properties of polymers and biomaterials. With these approaches, information about organized structures and their stability could be obtained in conditions when external factors affect biomolecules. Such changes might include rearrangement of macromolecular conformations at fabrication of nano-scaffolds for tissue engineering applications. The changes in water-fiber interactions could be mirrored by the magnetic resonance methods in various relaxations, double-quantum filtered (DQF), 1D and 2D translational diffusion experiments. These findings effectively demonstrate the current state of NMR studies in applying these experiments to the various systems with the anisotropic properties. For fibrous materials, it is shown how NMR correlation experiments with two gradients (orthogonal or collinear) encode diffusion coefficients in anisotropic materials and how to estimate the permeability of cell walls. It is considered how the DQF NMR technique discovers anisotropic water in natural polymers with various cross-links. The findings clarify hydration sites, dynamic properties, and binding of macromolecules discovering the role of specific states in improving scaffold characteristics in tissue engineering processes. Showing the results in developing these NMR tools, this review focuses on the ways of extracting information about biophysical properties of biomaterials from the NMR data obtained.

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Section: Mqf Nmr In Studying Anisotropic Mobilitymentioning

confidence: 99%

Section: Mqf Nmr In Studying Anisotropic Mobilitymentioning

confidence: 99%