Multiple Pulmonary Metastases From Giant Cell Tumor of a Hand

Moon, Jin Chang; Kim, So Ri; Lee, Yong Chul; Chung, Myung Ja

doi:10.1097/maj.0b013e31823483e1

Cited by 15 publications

(9 citation statements)

References 14 publications

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“…Some authors [23], [24] have suggested that pulmonary metastases are related to the type of surgery performed for the primary tumor. The surgery itself, not the invasiveness of the tumor, might lead to vascular differentiation because surgical manipulation enables implantation of tumor cells in the lung.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and risk factors analysis of lung metastasis from benign giant cell tumor of bone

Yang

Huang

Niu

et al. 2017

Journal of Bone Oncology

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Pulmonary metastasis of benign giant cell tumor of bone is very rare, and its biological behavior is difficult to predict. In the present study, we analyzed the clinical characteristics of and related risk factors for pulmonary metastasis from this tumor. Forty-six patients with lung metastasis were analyzed. In total, 60.9% of the primary tumors were located around the knee joint. The Campanacci stage of all tumors was stage 3. Surgery of the primary tumor included curettage in 37 patients, resection in 8, and amputation in 1. Local recurrence after the primary surgery occurred in 34 patients. The recurrence rate, Campanacci stage, and surgical method were significant risk factors for lung metastasis. The median postoperative metastasis times in the lower limbs, upper limbs, and axial skeleton were 20.1, 7.9, and 1.4 months, respectively (p=0.010). The median metastasis times in patients with and without recurrence were 13.7 and 43.2 months, respectively (p=0.018). Eighteen patients had unilateral metastasis and 28 had bilateral metastasis. Most lesions (n=38) were located in the peripheral lung. Nineteen patients received treatment, and 12 of them underwent tumor resection. The 5-year overall survival rate was 94.4%. This study showed that local recurrence, a high Campanacci stage, and curettage were possible high-risk factors for pulmonary metastasis. The primary lesion site and local recurrence may be related to the metastasis time. The survival rate of patients with pulmonary metastasis was high.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and risk factors analysis of lung metastasis from benign giant cell tumor of bone

Yang

Huang

Niu

et al. 2017

Journal of Bone Oncology

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“…It has the highest prevalence among the population aged between 20 and 40-years-old and has a slight female predominance [12], with the female to male ratio of 1.3 to 1.5:1.0 [13]. The most usual sites for GCT include distal femur, proximal tibia and distal radius [14–18].…”

Section: Reviewmentioning

confidence: 99%

Pulmonary metastasis of giant cell tumor of bones

Muheremu

Niu

2014

World J Surg Onc

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Giant cell tumor of bone (GCTB) accounts for 5% of primary skeletal tumors. Although it is considered to be a benign lesion, there are still incidences of pulmonary metastasis. Pulmonary metastasis of GCTB may be affected by tumor grading and localization as well as the age, gender and overall health status of the patient. Patients with local recurrence are more likely to develop pulmonary metastasis of GCTB. High expression of some genes, cytokines and chemokines may also be closely related to the metastatic potential and prognosis of GCTB. The treatment of the primary GCTB is key to the final outcome of the disease, as intralesional curettage has a significantly higher local recurrence and pulmonary metastasis rate than wide resection. However, even patients with pulmonary metastasis seem to have a good prognosis after timely and appropriate surgical resection. It is hoped that with the development of novel surgical methods and drugs, pulmonary metastasis of GCTB can be prevented and treated more effectively.

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“…Although categorized as a benign bone tumor, GCTBs have been reported to have recurrence rates of 8–62% ( 5 , 6 ) and metastatic rates of 1.5–7% ( 7 , 8 ). GCTBs may have a higher prevalence in females than males, as certain studies have reported a female-to-male ratio of 1.3–1.5:1.0 ( 9 , 10 ). The usual primary sites for GCTBs include the distal femur, proximal tibia and distal radius ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Treatment for giant cell tumor of the spine metastasizing to the lung: A report of two cases and a literature review

2014

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Giant cell tumors of the bone (GCTB) account for 5% of all primary skeletal tumors. Although the tumors are normally benign, recurrence and metastasis of GCTB does occur. The most usual sites of a primary GCTB lesion are the distal femur and proximal tibia, and ~3% of these metastasize to the lung. Primary GCTB lesions in the spine are rare, and there have been few cases reporting the pulmonary metastasis of GCTB in the spine. The present study reports two cases of thoracic and sacral spinal GCTB lesions with pulmonary metastasis. One of the patients was a 45-year-old male who presented to hospital with gradually worsening pain in the left buttock during the last two years and was diagnosed with GCTB of the sacrum. The other patient was a 30-year-old female who complained of persistent back pain for a year and was also diagnosed with GCTB of the sacrum. Arterial embolization was performed prior to surgery and computer navigation was used during the surgery, resulting in the two patients achieving en bloc resection of their respective tumors, with satisfactory rehabilitation to follow.

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Multiple Pulmonary Metastases From Giant Cell Tumor of a Hand

Cited by 15 publications

References 14 publications

Clinical characteristics and risk factors analysis of lung metastasis from benign giant cell tumor of bone

Clinical characteristics and risk factors analysis of lung metastasis from benign giant cell tumor of bone

Pulmonary metastasis of giant cell tumor of bones

Treatment for giant cell tumor of the spine metastasizing to the lung: A report of two cases and a literature review

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