Multiple Pulmonary Fibroleiomyomatous Hamartomas<sup>1</sup>

Logan, William D.; Rohde, Federico C.; Abbott, Osler A.; Meltzer, Harold D.

doi:10.1164/arrd.1965.91.1.101

Cited by 23 publications

(4 citation statements)

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“…Cases with multiple pulmonary hamartomata have been reported by Keers and Smith (1960), and Logan, Rohde, Abbott, and Meltzer (1965), but in eacl of these cases the tumours were of fibroleiomyomatous type, did not contain cartilage, and were different lesions from those under discussion. Wilkins (1955) reported a series of asymptomatic isolated pulmonary nodules; one of the series had two hamartomata (presumably cartilaginous) lying adjacent to each other in the basal segment of the left lower lobe.…”

Section: Discussionmentioning

confidence: 91%

Cartilage-containing tumours of the lung: Relationship between the purely cartilaginous type (chondroma) and the mixed type (so-called hamartoma): an unusual case of multiple tumours

Bateson¹

1967

Thorax

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Section: Discussionmentioning

confidence: 91%

Cartilage-containing tumours of the lung: Relationship between the purely cartilaginous type (chondroma) and the mixed type (so-called hamartoma): an unusual case of multiple tumours

Bateson¹

1967

Thorax

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“…PFLH is an extremely rare benign disease, it was descripted originally as "diffuse bro-leiomyomatous hamartomas of the Lung "by Cruickshank et al in 1953 [1], and then named as multiple Pulmonary broleiomyomatous hamartomas(MPFLH) by Logan et al in 1965 [2] and has been used until today. PFLH usually occur in adults and lack respiratory symptoms or have non-speci c respiratory system symptoms such as mild cough and expectoration, It also lack any speci city in laboratory examination results and been usually found during a medical examination.…”

Section: Introductionmentioning

confidence: 99%

Three unusual Pulmonary fibroleiomyomatous hamartomas: cases report and literature review

Song

Wang

Fu³

2021

Preprint

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BackgroundPulmonary fibroleiomyomatous hamartomas (PFLH) is an extremely rare benign leision, characterized by most patients have no respiratory symptoms and pulmonary nodules is found during rutine chest imaging. It’s completely different from fibrochondrolipoma (ie.chondrogenic pulmonary hamartoma, FCL), Herein, we report three unusual cases of PFLH in a 48-year-old male patient, a 63-year-old male patient and a 63-year-old female patient,respectively and discuss their morphological characteristics and differential diagnoses including fibrochondrolipoma (FCL), pulmonary fibroadenoma (PFA), primary pulmonary leiomyoma (PPL), bronchioloalveolar adenoma (BAA), solitary fibrous tumor (SFT) and pulmonary metastatic leiomyoma (PML) in female patients.Case presentationThree cases showed singler and multiple nodules in the pulmonary parenchyma,the boundary of these nodules was clear. it showed swelling growth and lobulated in larger tumors. it consisted of the mesenchymal rich in spindle cells and the glandular epithelium tissue. the spindle cells form smooth muscle tissue and fibrous tissue, the glandular epithelium with invagination showed glandular ducts or fissures, disorder of composition. Immunohistochemical staining showed Desmin, SMA,H-caldesmon-positive in the all spindle cells; H-caldesmon-positive, SMA-weak positive and desmin-negative in the long spindle cells; TTF-1,CK7 were positive in glandular epithelium and P63,CK5/6 were expressed in basal cells; HMB45,S-100,CD34, ER,PR were negative in all cells. Additionally, Ki-67 VPI was low and less than 1%. The immunohistochemical analysis combined with the morphological results supported the diagnosis of solitary PFLH (SPFLH) or multiple PFLH (M PFLH). There was no recurrence in SPFLH and recurrence in MFLH in the group.ConclusionsPFLH is a rare benign leision .It originated from the small bronchus or smooth muscle cells of vascular wall which implanted into the lung parenchyma and overgrowth into nodules or mass, the messenchymal component of PFLH is the most important for accurate pathological diagnosis, PFLH is easy to be confused with PFA and PPL when there are not enough immune marker such as SMA,desmin, H-caldesmon to mark the mesenchymal components. Therefore, Diagnosis of PFLH mainly depends on pathological examination, females patients have to exclude PML.

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“…In 1963, Blair and McElvein found only 225 reported operative cases in the literature. While this tumour as a single nodule is rare, multiple hamartomata of the lung are very rare; there have been only three cases reported in the world literature (Logan, Rohde, Abbott, and Meltzer, 1965). It is the purpose of this paper to present another case of multiple hamartomata of the lung.…”

mentioning

confidence: 94%

“…We had no opportunity to review this case as the thesis was burned in the first world war. The second and third cases of multiple hamartomata of the lung were reported by Keers and Smith (1960) and Logan et al (1965) respectively.…”

mentioning

confidence: 99%

Multiple hamartomata of the lung.

Madani¹,

Dafoe²,

Ross³

1966

Thorax

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Multiple Pulmonary Fibroleiomyomatous Hamartomas¹

Cited by 23 publications

References 4 publications

Cartilage-containing tumours of the lung: Relationship between the purely cartilaginous type (chondroma) and the mixed type (so-called hamartoma): an unusual case of multiple tumours

Cartilage-containing tumours of the lung: Relationship between the purely cartilaginous type (chondroma) and the mixed type (so-called hamartoma): an unusual case of multiple tumours

Three unusual Pulmonary fibroleiomyomatous hamartomas: cases report and literature review

Multiple hamartomata of the lung.

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Multiple Pulmonary Fibroleiomyomatous Hamartomas1

Cited by 23 publications

References 4 publications

Cartilage-containing tumours of the lung: Relationship between the purely cartilaginous type (chondroma) and the mixed type (so-called hamartoma): an unusual case of multiple tumours

Cartilage-containing tumours of the lung: Relationship between the purely cartilaginous type (chondroma) and the mixed type (so-called hamartoma): an unusual case of multiple tumours

Three unusual Pulmonary fibroleiomyomatous hamartomas: cases report and literature review

Multiple hamartomata of the lung.

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About

Multiple Pulmonary Fibroleiomyomatous Hamartomas¹