Multiple protective effect of peptides released from Olea europaea and Prunus persica seeds against oxidative damage and cancer cell proliferation

Hernández-Corroto, Ester; Marina, Marı́a Luisa; García, María Concepción

doi:10.1016/j.foodres.2018.01.015

Cited by 37 publications

(39 citation statements)

References 36 publications

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“…Consistent with other studies [3][4][5], the results of the present study suggested that, firstly, the prevalence of -308G/A polymorphism varies among different populations, and more studies are needed in this area. Secondly, in infertile men with this polymorphism, we observed a decrease in sperm parameters, an increase in oxidative stress, sperm DNA damage, and apoptosis in the sperm cells which ultimately reduced the normal parameters of the sperms.…”

Section: Resultssupporting

confidence: 91%

“…Mutations of autosomal genes are also closely related to male infertility; however, the underlying molecular mechanisms are still unknown [3,4]. Various studies have shown the association between different genotypes of cytokines encoding genes and infertility [5][6][7][8]. Tumor necrosis factor alpha (TNF-α) is a cytokine that is normally present in the male genital tract.…”

Section: Introductionmentioning

confidence: 99%

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Association of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility

Najafipour

Moghbelinejad

Aboutorabi

et al. 2019

J. Qazvin Univ. Med. Sci.

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Background The tumor necrosis factor alpha (TNF-α) gene is a cytokine involved in systemic inflammation. Results of the association of its polymorphisms with infertility in men are controversial. Objective The aim of this study was to evaluate the association of-308G/A polymorphism in TNF-α gene with different parameters of semen and sperm in infertile men. Methods Participants were 210 men with infertility and 120 controls. The polymorphism evaluation was performed by sequencing method. In order to assess oxidative stress and apoptosis in men with-308G/A polymorphism, malondialdehyde and caspase-9 values were measured. The sperm DNA damage and sex chromosomes aneuploidy were also measured in these patients. Findings A significant higher frequency of A allele of-308G/A polymorphism was observed in men with oligoasthenospermia (P=0.01). In semen samples of the men with AA genotype, there was significantly high level of malondialdehyde and caspase-9 (P<0.0001). We also observed higher frequency of sperm DNA damage (P=0.0001) and sex chromosome disomy type XY (P=0.0001) in sperm samples of men with AA genotype of-308G/A polymorphism. Furthermore, there was a significant correlation between sex chromosome aneuploidy and sperm DNA damage in sperms of men with this polymorphism (R=0.72, P=0.048). Conclusion-308G/A polymorphism of TNF-α gene has association with decreased sperm parameters, increased oxidative stress, higher sperm DNA damage and sex chromosome aneuploidy which can affect infertility.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Association of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility

Najafipour

Moghbelinejad

Aboutorabi

et al. 2019

J. Qazvin Univ. Med. Sci.

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“…Oxidative stress is caused by the presence of high amounts of reactive oxygen species (ROS) that overcome endogenous antioxidant defense mechanisms. Maintained oxidative stress can lead to the development of serious diseases by damaging important biomolecules such as DNA, proteins, and lipids [16]. Different studies have demonstrated that antioxidant intake is inversely related to cellular death, aging, and the development of diseases such as diabetes and cancer [17].…”

Section: Antioxidant Peptides In Fruit Residuesmentioning

confidence: 99%

Extraction and Characterization of Antioxidant Peptides from Fruit Residues

Olivares-Galván

Marina

García

2020

Foods

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Fruit residues with high protein contents are generated during the processing of some fruits. These sustainable sources of proteins are usually discarded and, in all cases, underused. In addition to proteins, these residues can also be sources of peptides with protective effects against oxidative damage. The revalorization of these residues, as sources of antioxidant peptides, requires the development of suitable methodologies for their extraction and the application of analytical techniques for their characterization. The exploitation of these residues involves two main steps: the extraction and purification of proteins and their hydrolysis to release peptides. The extraction of proteins is mainly carried out under alkaline conditions and, in some cases, denaturing reagents are also employed to improve protein solubilization. Alternatively, more sustainable strategies based on the use of high-intensity focused ultrasounds, microwaves, pressurized liquids, electric fields, or discharges, as well as deep eutectic solvents, are being implemented for the extraction of proteins. The scarce selectivity of these extraction methods usually makes the subsequent purification of proteins necessary. The purification of proteins based on their precipitation or the use of ultrafiltration has been the usual procedure, but new strategies based on nanomaterials are also being explored. The release of potential antioxidant peptides from proteins is the next step. Microbial fermentation and, especially, digestion with enzymes such as Alcalase, thermolysin, or flavourzyme have been the most common. Released peptides are next characterized by the evaluation of their antioxidant properties and the application of proteomic tools to identify their sequences.

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“…Cardio protective, antioxidant and anti-inflammatory properties of Olive Leave Extracts (OLEs) have been demonstrated in many studies [7,8]. The positive effects of Olea europaea L. in inducting apoptosis and antioxidant properties in human colon and cervical cancer cell lines have already been reported [9,10]. In another study in 2019, improvement of lipid and antioxidants levels following treatments by 400 mg/kg OLE was reported in streptozotocin induced diabetic rats [11].…”

Section: Introductionmentioning

confidence: 98%

Determining Cardiometabolic and Antioxidant Effects of Olive Leaf Extract in Patients with Essential Hypertension

Yaghoobzadeh

Mehravar

Javadi

et al. 2019

J. Qazvin Univ. Med. Sci.

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ics, family history, environmental factors and social and behavioral characteristics have critical role in the incidence of hypertension [2]. Despite our understanding of the disease and accessibility of treatments, it was estimated that around 30% of the world's population will be affected by this disease by 2025, indicating a major unrelieved public health burden [3-5]. Herbal medicine has been used for a long time to achieve therapeutic goals [6]. Extracts of olive leaves (Olea

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Multiple protective effect of peptides released from Olea europaea and Prunus persica seeds against oxidative damage and cancer cell proliferation

Cited by 37 publications

References 36 publications

Association of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility

Association of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility

Extraction and Characterization of Antioxidant Peptides from Fruit Residues

Determining Cardiometabolic and Antioxidant Effects of Olive Leaf Extract in Patients with Essential Hypertension

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