Multiple prohibited ingredients detected in nutritional supplements in a case of adverse analytical finding (AAF)

Annual banned‐substance review 16th edition—Analytical approaches in human sports drug testing 2022/2023

“…More than 50% of the study participants declared the use of dietary supplements, 9,10 and data suggest that such dietary supplement use is, to some extent, also a gateway to the use of prohibited performance enhancing substances 11,12 . Besides, the issue of contaminated and adulterated dietary supplements resulting in AAFs during doping controls still exists, both in manufactured and compounded products, 13,14 which substantially increases the risk of AAFs and ADRVs as well as health issues as recently outlined by Pascali et al 15 and Tran et al 16 …”

“…More than 50% of the study participants declared the use of dietary supplements, 9,10 and data suggest that such dietary supplement use is, to some extent, also a gateway to the use of prohibited performance enhancing substances. 11,12 Besides, the issue of contaminated and adulterated dietary supplements resulting in AAFs during doping controls still exists, both in manufactured and compounded products, 13,14 which substantially increases the risk of AAFs and ADRVs as well as health issues as recently outlined by Pascali et al 15 and Tran et al 16 Advancing test methods for doping controls is vital for modern sports drug testing programs, 17 as demonstrated by attributable effects and impact 18 as well as their implementation into routine application at major sporting events. 19,20 Research aiming at facilitating such advances are commonly aligned with the World Anti-Doping Agency's (WADA's) Prohibited List 21 and its 11 classes of banned substances (S0-S9 plus P1) and three categories of prohibited methods (M1-M3) (Table 1).…”