Multiple primary melanomas

Stam-Posthuma, J. J.; Duinen, Caroline van; Scheffer, E.; Vink, Jacqueline; Bergman, Wilma

doi:10.1067/mjd.2001.110878

Cited by 65 publications

(71 citation statements)

References 31 publications

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“…Clinical data on the presence of atypical nevi were not available in the current study; however, it has been well documented that patients who have a history of dysplastic nevi have an increased risk of developing MPM. 9,10,[12][13][14]18 To be sure, differences in the rate of having a positive family history of melanoma were not statistically significant in our study, probably because of the increased frequency of having a family history of melanoma in patients with SPM (15%) in our population compared with what has been reported previously in North America. The reasons for this may include disparities in population size and data collection methods (retrospective vs prospective) among studies.…”

Section: Discussioncontrasting

confidence: 40%

“…3,6,7,9,12,[15][16][17][18][19][20] A study from the John Wayne Cancer Institute examined the first 2 primary melanomas in 114 patients with MPM who were identified from a melanoma database and demonstrated that there were significant differences between AJCC stage, mean tumor thickness, and Clark level of invasion between the first and second melanomas, and the second melanoma was thinner. 21 Our results indicating that the thickness of the first primary melanoma is significantly greater compared with the thickness of the second melanoma are consistent with previously reported findings.…”

Section: Discussionmentioning

confidence: 99%

“…10,[12][13][14] The initial melanoma in patients who have multiple primary melanomas (MPM) usually is the thickest of the melanomas that eventually develop. 3,6,7,9,12,[15][16][17][18][19][20][21] The 2 competing explanations for this trend include early detection of subsequent melanomas and less aggressive tumor biology in patients with MPM. Supporting the early detection hypothesis, a 2010 retrospective study by de Giorgi et al suggested that patients with MPM who did not adhere to regular follow-up had significantly thicker melanomas than patients who attended regular follow-up (mean thickness, 1.22 mm vs 0.36 mm).…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Various single-center and population-based studies have reported that between 1.2% and 8.6% of patients who have a history of melanoma will develop subsequent melanomas. [3][4][5][6][7][8][9][10][11][12] Several risk factors for the development of more than 1 primary melanoma have been established, the most important of which include a family history of melanoma and a personal history of dysplastic nevi. 10,[12][13][14] The initial melanoma in patients who have multiple primary melanomas (MPM) usually is the thickest of the melanomas that eventually develop.…”

Section: Introductionmentioning

confidence: 99%

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Single versus multiple primary melanomas

Hwa

Price

Belitskaya-Lévy

et al. 2012

Cancer

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BACKGROUND:In patients with multiple primary melanomas (MPM), mean tumor thickness tends to decrease from the first melanoma to the second melanoma, and prognosis may be improved compared with the prognosis for patients who have a single primary melanoma (SPM). In this study, the authors compared the clinicopathologic features of patients with MPM and SPM to better characterize the differences between these 2 groups and to determine whether or not there is an inherent difference in tumor aggression. METHODS: In total, 788 patients with melanoma who were enrolled prospectively in the Interdisciplinary Melanoma Cooperative Group database from 2002 to 2008 were studied. Patients with SPM and with MPM were compared with regard to clinical and primary melanoma characteristics. RESULTS: Of 788 patients with melanoma, 61 patients (7.7%) had 2 or more primary melanomas. The incidence of developing a second primary melanoma 1 year and 5 years after initial melanoma diagnosis was 4.1% and 8.7%, respectively, and most of the risk accumulated within the first year. The incidence of MPM was greater in patients aged !60 years than in those aged 60 years. The absence or presence of mitosis and other tumor characteristics did not differ significantly between patients with SPM and patients with MPM (P ¼ .61). CONCLUSIONS: No difference was observed in the presence or absence of mitoses, a marker of tumor proliferation, in SPM and MPM. Because it has been demonstrated that the presence of mitosis is a powerful prognostic marker, the current findings suggested that the tumors behave similarly in patients with SPM and patients with MPM. The authors concluded that differences in tumor thickness and prognosis between SPM and MPM more likely are caused by factors other than tumor biology, such as increased surveillance. Cancer 2012;118:4184-92.

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Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Single versus multiple primary melanomas

Hwa

Price

Belitskaya-Lévy

et al. 2012

Cancer

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“…Studies of risk of multiple primary melanomas have been concerned mainly with influences of the previous history of melanoma, presence of dysplastic nevi, or possible genetic susceptibility [2][3][4]. While sun exposure is recognized as the major cause of melanoma in populations of European origin [5], studies of sun exposure and melanoma so far published have compared sun exposure in people with a first melanoma, or any melanoma, with that in people who have not had a melanoma.…”

Section: Introductionmentioning

confidence: 99%

Ambient UV, personal sun exposure and risk of multiple primary melanomas

Kricker

Armstrong

Goumas

et al. 2007

Cancer Causes Control

107

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Objective-Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one melanoma.Methods-We identified and enrolled 2,023 people with a first primary melanoma (controls) and 1,125 with multiple primary melanomas (cases) in seven centers in four countries, recorded their residential history to assign ambient UV and interviewed them about their sun exposure.Results-Risk of multiple primary melanomas increased significantly (P < 0.05) to OR = 2.10 for the highest exposure quarter of ambient UV irradiance at birth and 10 years of age, to OR = 1.38 for lifetime recreational sun exposure, to OR = 1.85 for beach and waterside activities, to OR = 1.57 for vacations in a sunnier climate, to OR = 1.50 for sunburns. Occupational sun exposure did not increase risk (OR = 1.03 for highest exposure). Recreational exposure at any age increased risk and appeared to add to risk from ambient UV in early life.Conclusions-People who have had a melanoma can expect to reduce their risk of a further melanoma by reducing recreational sun exposure whatever their age. The same is probably true for a person who has never had a melanoma.

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