Multiple primary malignant tumors of the head and neck

Cohn, Arnold M.; Peppard, Sean B.

doi:10.1016/s0196-0709(80)80022-6

Cited by 76 publications

(24 citation statements)

References 19 publications

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“…Several studies report that SPT of the esophagus are the leading cause of treatment failure and death in patients with HNSCC. [19][20][21] In a group of patients treated at Sant Pau Hospital in Barcelona, the 15-year observed survival rate for patients with SPT was 22%, significantly lower than the 54% for patients without SPT. 19 Among them, patients with second primary esophageal cancers had the worst outcome, with a 5-year survival of 6%.…”

Section: Discussionmentioning

confidence: 95%

Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer

et al. 2011

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Section: Discussionmentioning

confidence: 95%

Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer

et al. 2011

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“…The presence of more than one primary carcinoma has a profound influence on survival, and therefore management. Cohn and Peppard (1980) found that 75 per cent of patients who developed second primary tumours in the upper aerodigestive tract died within 12 months of the second diagnosis. Gluckman and Crissman (1983) found that overall five-year survival after diagnoisis of a second primary was 22.3 per cent (compared with 35 per cent for a control group with single lesions).…”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy of malignant and premalignant lesions in patients with ’field cancerization‘ of the oral cavity

et al. 1993

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The management of patients with 'field cancerization' of the oral mucosa, with multicentric foci of invasion, presents a considerable problem for the head and neck surgeon. Surgical resection of synchronous or metachronous primary squamous cell carcinomas, along with adjacent premalignant lesions, is likely to be associated with considerable mutilation. Photodynamic therapy (PDT) has been shown to be of value in the treatment of superficial tumours in the upper aerodigestive tract, with excellent healing of treated areas. This study reports the use of PDT to treat 11 patients with 'field cancerization' occurring in the oral cavity. Six patients had multiple primary cancers and five had single primary tumours. All had associated areas of leukoplakia. Each received Photofrin 2 mg/kg 48 hours prior to photoirradiation with 50-100 J/cm 2 red laser light by surface illumination. Six to eight weeks later treated areas in 10 of the 11 patients showed a complete response to PDT; one patient had areas of residual leukoplakia. Two patients developed further areas of leukoplakia or erythroplakia within 12 months but no patient has had evidence of recurrent invasive carcinoma in the treated areas. Longer term follow-up will be necessary to exclude further recurrence. It is concluded that PDT offers an effective repeatable treatment option, whether on its own or as an adjunct to local excision, for patients with 'field cancerization' of the oral cavity.

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“…Consistent with this overall theory, recent investigations examining the molecular basis of SPTs claim that at least a proportion of these originate from a single contiguous pre-malignant epithelial field, the so called second field tumours [11,12]. Studies differ widely (2-30%) in their estimated risk of SPT development in part due to inconsistencies in patient selection or diagnostic criteria as well as generally inadequate follow up ( [3][4][5][6]8,10,[13][14][15][16][17][18][19][20][21][22][23][24][25][26]. It is generally accepted that diagnosis of the index tumour in concert with the premise of field cancerisation imparts a subsequent permanent risk of developing SPT [2][3][4][5][6]20,27].…”

Section: Discussionmentioning

confidence: 99%

Second Primary Tumours of the Head and Neck are not Associated ith Adverse Overall Survival in Oral Sccs

Farhadieh¹,

Otáhal²,

Taghavi³

et al. 2011

JCST

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Objective: Second primary tumours (SPT) have been implicated in the dismal overall survival (OS) of head and neck Squamous cell carcinomas (HNSCC). The incidence of SPT, the SPT diagnostic time-lag and the impact on OS were assessed.Subjects and methods: 363 consecutive patients treated for primary oral SCCs (1967SCCs ( -2004 were analyzed retrospectively in this study. 95.1% and 90.5% of patients reached a minimum follow-up period of 3 and 5 years respectively.Results: Of 363 patients; 68 (18.7%) were diagnosed with metachronous SPT, 49 (13.5%) developed upper aerodigestive tract (UAD)-SPT, 28 (7.7%) were diagnosed with HNSCC-SPT, and 21 (5.8%) developed lung or esophageal carcinoma. Patients with subsequent HNSCC-SPT had a better median survival during follow-up than those not diagnosed with SPTs (p=0.0018). The rate of mortality in these patients showed a substantial increase compared to patients with no subsequent SPT Diagnosis after 144 months. After 200 months the survival experience was no better than those without SPT. Conclusion:These results suggest a better OS for patients afflicted with HNSCC-SPT. This also reflects that at least some of the noted improved OS of HNSCC-SPT patients is due to temporally cumulated risk associated with developing SPT.

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Multiple primary malignant tumors of the head and neck

Cited by 76 publications

References 19 publications

Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer

Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer

Photodynamic therapy of malignant and premalignant lesions in patients with ’field cancerization‘ of the oral cavity

Second Primary Tumours of the Head and Neck are not Associated ith Adverse Overall Survival in Oral Sccs

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