Multiple Primary Malignant Neoplasms in an Elderly Patient

Parekh, Jai; Kukrety, Shweta; Thandra, Abhishek; Valenta, Carrie

doi:10.7759/cureus.2384

Cited by 9 publications

(15 citation statements)

References 8 publications

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“…There are no currently available standard guidelines for MPMN treatment. Malignancy type, disease stage and the overall health of the patient are each considered (12), and each patient has multidisciplinary individualized treatment.…”

Section: Discussionmentioning

confidence: 99%

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Multiple primary malignant neoplasms: A case report and literature review

et al. 2019

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Until recently, few cases of three or more malignant tumors in one patient have been reported. Owing to the high incidence rate of these tumors, the improvement in cancer diagnosis and treatment, and the extension of patient survival time, the incidence of reported multiple primary malignant neoplasms has gradually increased. The present study reported the case of a 57-year-old man with non-small cell lung cancer combined with B-Raf proto-oncogene serine/threonine kinase V600E mutation, gastrointestinal stromal tumors and lumbar vertebral malignant mucinous sarcoma. The pathogenesis, diagnosis and treatment of these three malignancies are discussed and previous studies are also reviewed. The aim of the study was to analyze the genetic mutations associated with multiple primary malignant tumors and to discuss whether those mutations with unknown functional significance could be used as therapeutic indicators. This case report will serve as a reference for future treatment of such patients.

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Section: Discussionmentioning

confidence: 99%

“…Thus, long-term application of targeted drug therapy may also increase the incidence of secondary malignant tumors. In 2002, Surveillance Epidemiology and End Results data indicated that ~16% of all new cancer cases were secondary or higher-order primary cancer in the United States (12).…”

Section: Discussionmentioning

confidence: 99%

Multiple primary malignant neoplasms: A case report and literature review

et al. 2019

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“…Eight cases experienced dead/metastasis or recurrence. [ 3 , 4 , 13 , 16 , 17 , 19 , 20 , 24 ] The outcomes of cases were not reported. [ 6 – 9 , 23 ]…”

Section: Discussionmentioning

confidence: 99%

Triple metachronous primary cancer of uterus, colon, and breast cancer

Li¹,

Yao²,

et al. 2020

Medicine

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Rationale: Triple or more primary malignancies are rare, with only 23 previous cases including breast cancer reported in the English language studies between January 1990 and December 2019. Patient concerns: The patient was a 67-year-old woman with a mass in her right breast. She had a previous history of uterine and colon cancer. Both ultrasonography and mammography revealed a Breast Imaging Reporting and Data System (BI-RADS) category 3 breast lesion, in which proliferative nodules are more likely. Given her previous history of 2 malignancies, her doctors strongly recommended a biopsy. Diagnosis and interventions: The biopsy pathology suggested intraductal breast cancer. Mastectomy and sentinel lymph node biopsy were performed. The postoperative pathological diagnosis was invasive ductal carcinoma, grade II, stage I. The sample was positive for estrogen receptor and progesterone receptor and negative for cerbB-2. No radiotherapy or chemotherapy was administered except for endocrine therapy. A follow-up at 19 months showed no breast recurrence or distant metastases. Outcomes: No recurrence or distant metastasis occurred within the 19-month, 11-year, and 20-year follow-ups for breast, colon, and uterine cancers, respectively. Lessons: To our knowledge, this is the first review of triple or more primary malignancies including breast cancer. These malignancies occur predominantly in older female patients. The most prevalent tumors of triple or more primary malignancies including breast cancer occur in the colon, uterus, and lung. A favorable prognosis is associated with early-stage malignancies.

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“…Breast cancer and urological tumors. Bladder and breast cancers share extrinsic risk factors (including personal lifestyle, ultraviolet radiation, smoking and alcohol) and some genetic mutations in signal transduction pathways (95,96). Damrauer et al showed that basal-like and luminal-like subtypes of bladder cancer surprisingly reflect the hallmarks of breast biology (97).…”

Section: Breast Cancer and Gynecological Tumorsmentioning

confidence: 99%

“…If the generic association of breast cancer with urological tumors can be considered sporadic (11,12,16,31,44,61,76,86,95,96), the same cannot be said for bladder cancer (11,12,76,95).…”

Section: Breast Cancer and Gynecological Tumorsmentioning

confidence: 99%

Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

Luca

Frusone

Vergine

et al. 2019

In Vivo

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Multiple primary malignant neoplasms are multiple tumors with different pathogenetic origin. They may be synchronous or metachronous. The management of these conditions represents an interesting clinical scenario. A crucial aspect is the decision regarding which tumor to treat initially, and how to schedule further treatments according to individual tumor risk. This process involves a multidisciplinary physician team to ensure favorable outcomes. We describe a case report of a female patient affected by primary synchronous tumors of the breast and pectoral skin, which raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature. Multiple primary malignant neoplasms (MPMNs), or multiple primary cancers, are defined as multiple tumors with different pathogenetic origin. The phenomenon of MPMN was first described by Billroth at the end of the 19th century (1) and since then several cases of double or even triple primary malignant neoplasms have been reported (1-3). Neoplasms can be synchronous or metachronous and may appear in a single organ or in multiple organs concurrently. According to Moertel (2), synchronous neoplasms are defined as those that occur within 6 months from the diagnosis of a previous malignant tumor, and metachronous neoplasms are defined as neoplasms that appear 6 months after the first diagnosed tumor (2). Despite many changes in the definition have been proposed, the diagnosis of MPMNs that is widely accepted is based on the criteria described by Warren and Gates (3). These criteria require that: (i) each tumor must have a clear picture and histological confirmation of malignancy; (ii) each tumor must be topographically distinct and separated by healthy mucosa (at least 2 cm of normal mucosa between two tumors of the same region); (iii) the lesions must be not metastases of each other (3). In this report, we describe our recent observation and treatment of a female patient affected by primary synchronous tumors of the breast and pectoral skin. This combination, to the best of our knowledge, has never been previously reported in the literature, and it raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature.

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Multiple Primary Malignant Neoplasms in an Elderly Patient

Cited by 9 publications

References 8 publications

Multiple primary malignant neoplasms: A case report and literature review

Multiple primary malignant neoplasms: A case report and literature review

Triple metachronous primary cancer of uterus, colon, and breast cancer

Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

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