Multiple Primary Malignancies in Renal Cell Carcinoma

Rabbani, Farhang; Grimaldi, Gregory; Russo, Paul

doi:10.1097/00005392-199810000-00012

Cited by 21 publications

(41 citation statements)

References 15 publications

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“…The percentage of patients having more than one other primary cancer in the present study is concurrent with earlier reports [4]. By contrast, there are differences in the percentage of other primary tumours detected subsequently.…”

Section: Discussionsupporting

confidence: 92%

“…The probable cause of this is the longer observation time in the present study. Previous studies [2][3][4][5][6][7], also supported by the present study, suggest that prostate, breast, colorectal, bladder, NHL and lung cancer seem to be the most common other primary cancers in patients with RCC.…”

Section: Discussionsupporting

confidence: 88%

“…By contrast, there are differences in the percentage of other primary tumours detected subsequently. In the present study, almost half were diagnosed subsequently, while earlier studies reported 15-23% [2,4]. The probable cause of this is the longer observation time in the present study.…”

Section: Discussioncontrasting

confidence: 59%

“…A national registry like the Cancer Registry of Norway also has the advantage of a uniform practice in reporting and coding. Some authors [4] indicated that hospital series may have advantages over population-based series; they are said be more accurate for tumour stage and pathology reports [4], and are also claimed to have better follow-up data, so potential sources of bias may be discovered [4]. However, by manually checking all clinical and histopathology report forms, we tried to eliminate registration errors, and to ensure the quality of the data set so that it resembles the data available at the hospitals.…”

Section: Discussionmentioning

confidence: 99%

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Multiple primary malignancies in patients with renal cell carcinoma: a national population‐based cohort study

et al. 2006

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expected number of different tumour types was calculated according to age group, gender and observation time. RESULTSOf the 1425 patients, 228 (16%) had one, 23 (1.6%) had two, three (0.2%) had three and one (0.07%) had four other primary malignancies. In all, 100 (34.8%) of the other tumours were diagnosed as antecedent, 53 (18.7%) as synchronous and 134 (46.7%) as subsequent to the RCC. Cancer in the prostate, bladder, lung, breast, colon and rectal cancer, malignant melanomas (MM) and non-Hodgkin's lymphomas (NHL) were the most common other malignancies. The observed overall number of subsequent other malignant tumours was 22% higher than the expected number. The observed number of subsequent tumours was significantly higher for bladder cancer, NHL and MM. The estimated 15-year cumulative risk for patients with RCC and no previous or synchronous other malignancy for developing a later second cancer was 26.6% in men, and 15.5% in women (statistically significant, P = 0.04). Patients with antecedent or synchronous other cancer had significantly poorer overall survival than those without. CONCLUSIONSPatients with RCC seem to have a significantly higher risk of developing other subsequent primary malignancies. This should be considered during the follow-up of patients with RCC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Multiple primary malignancies in patients with renal cell carcinoma: a national population‐based cohort study

et al. 2006

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“…A study of patients at Memorial Sloan Kettering Cancer Center showed that 26.9% of patients treated for RCC had an antecedent, synchronous or subsequent malignancy [15]. Patients with RCC had an incidence of synchronous or subsequent prostate cancer that was significantly higher than the population incidence.…”

Section: Discussionmentioning

confidence: 99%

A population‐based study of renal cell carcinoma and prostate cancer in the same patients

et al. 2005

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OBJECTIVETo investigate the incidence of prostate cancer in men with renal cell carcinoma (RCC) and the incidence of RCC in men with prostate cancer. METHODSWe evaluated the database of the Surveillance, Epidemiology and End Results Program of the National Cancer Institute from 1973 to 1996, to calculate the incidence of RCC in men with prostate cancer and the incidence of prostate cancer in men with RCC. The standardized incidence ratio (SIR, observed/expected) was calculated for each of the scenarios of interest, as well as for RCC and prostate cancer in men with other common malignancies. Lung/bronchus cancer, colon/rectal cancer, and non-Hodgkin lymphoma were selected for the control scenarios because they are the most common non-urological cancers among men in the USA. RESULTSThere was a higher incidence of RCC in men with prostate cancer (SIR 1.25, P < 0.01). RCC incidence was also higher in men with each of the other malignancies. Prostate cancer incidence was higher in men with RCC (SIR 1.42, P < 0.001), but was not significantly elevated for any of the control scenarios. CONCLUSIONSThe incidence of RCC is higher in men with each of the index cancers, whereas that for prostate cancer was higher only in men with RCC. A common aetiological factor is possible. However, it is also possible that detection bias explains these findings. Serial imaging might increase the detection of RCC among patients with a variety of index malignancies. Patients with RCC who are followed by a urologist might be screened more rigorously for prostate cancer than patients with other primary malignancies, leading to increased detection in these men.

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Cancer of the Kidney

Russo¹

Surgical Oncology

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Multiple Primary Malignancies in Renal Cell Carcinoma

Abstract: Breast, prostate, colorectal and bladder cancer as well as non-Hodgkin's lymphoma were the most common other primary malignancies. Men with renal cell carcinoma have an increased risk of subsequent bladder cancer.

Cited by 21 publications

References 15 publications

Multiple primary malignancies in patients with renal cell carcinoma: a national population‐based cohort study

Multiple primary malignancies in patients with renal cell carcinoma: a national population‐based cohort study

A population‐based study of renal cell carcinoma and prostate cancer in the same patients

Cancer of the Kidney

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