Multiple primary intracranial tumors

McPhedran, Rachel; Tom, Martin

doi:10.1212/wnl.12.8.524

Cited by 12 publications

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“…There are few cases in the literature, the coexistence of a meningioma and a glioma being the most reported combination, followed by a meningioma with a vestibular schwannoma and a meningioma with a pituitary adenoma. [ 3 7 13 14 15 16 17 18 19 21 25 ] The recent advance in neuroimaging for the diagnosis of brain tumors has resulted in more additional reports of multiple primary brain tumors, with multiple other cases of coexistence of pituitary adenoma and temporal lobe glioma,[ 9 ] prolactinoma and craniopharyngioma,[ 5 ] epidermoid cyst tumor, and pituitary adenoma[ 11 ] described. Co-occurrence of meningioma and an epidermoid cyst has barely been reported previously.…”

Section: Discussionmentioning

confidence: 99%

Unusual coexistence of an epidermoid cyst with an atypical meningioma: Case report and review of the literature

et al. 2016

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Background:Coexistence of multiple primary intracranial tumors of different cell types has rarely been documented; the association of a meningioma and a glioma has been reported as the most common combination. Hereby, we report an unusual case of a temporal epidermoid cyst coexisting with an atypical meningioma.Case Presentation:A 37-year-old male presented with progressive symptoms of raised intracranial progression with progressive loss of vision without any neurological deficit. On admission, magnetic resonance imaging (MRI) revealed a right frontal lesion appearing hypointense T1, hyperintense T2 slightly enhanced after gadolinium and a second right temporal, isointense T1, hyperintense T2 non-enhancing lesion. A right frontotemporal craniotomy was performed that revealed two distinct lesions: The whitish temporal lesion with the pearl appearance reminding of an epidermoid cyst, the second lesion was extraaxial fibrous lesion arising from the falx. Pathology confirmed an atypical meningioma WHO Grade II and an epidermoid cyst.Conclusion:The simultaneous occurrence of primary intracranial tumors of different cell types is rare. Epidermoid cysts are slow growing lesions believed to arise from inclusion of ectodermal elements during neural tube closure, while meningiomas arise from arachnoidal cells; their association has rarely been reported previously.

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Section: Discussionmentioning

confidence: 99%

Unusual coexistence of an epidermoid cyst with an atypical meningioma: Case report and review of the literature

et al. 2016

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“…One patient had DI for 10 years before the tumor was discovered [15]. Glioma and pituitary adenoma have been noted in 5 patients [16][17][18][19]. All of the gliomas were hemispheric and were often in close proximity to the adenoma.…”

Section: Pathology Discussionmentioning

confidence: 99%

Progressive Brainstem Disease in a 32‐Year‐Old Man with a Pituitary Adenoma and Longstanding Diabetes Insipidus

Sanders¹,

Fetell²

1992

Journal of Neuroimaging

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A 32-year-old man who had unexplained diabetes insipidus for 14 years developed hypogonadism and was found to have a pi- Presentation of CaseA 32-year-old engineer noted tingling of the right hand and foot 5 months after uncomplicated transsphenoidal pituitary adenectomy.At age 18, in 1975, he had developed diabetes insipidus (DI) and had been treated with chlorpropamide and later desmopressin acetate (DDAVP). There had been no history of radiation therapy or head trauma and no family members had DI. At that time, visual fields and skull radiographs were normal. Measurements of growth hormone (GH), thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), Received May 1, 1991, and in revised form Jun 1L Accepted for publication Jun 13, 199LAddress correspondence to Dr FetelL adrenocorticotropic hormone (ACTH), and cortisol were within normal limits. The testosterone level was low normal, at 360 ngjdl (normal, 300-900 ng/dl). Seven years later the testosterone level was 184 ng/dl (normal, 300-1,200 ngjdl) but he fathered his second child. Head computed tomograms (CT) in axial and coronal planes appeared normal at this time.Difficulty fathering a third child at age 32 prompted reevaluation. He noticed less frequent shaving but no change in glove or shoe size. Findings on neurological examination, including visual fields, were normal. The testosterone level was 16 ng/dl (normal, > 300 ng/dl); GH, TSH, LH, FSH, and ACTH levels were normal. Prolactin measured 30 ngjml (normal, 0-20 ng/ml). A T1-weighted magnetic resonance image (MRI) in the sagittal plane showed a 2 X 2.5-cm sellar mass that projected upward to reach the inferior portion of the optic chiasm (Fig 1). A T1-weighted study with gadolinium enhancement demonstrated that the sellar mass was uniformly enhanced and that there was an irregular enhancing mass in the pons (Fig 2). A T2-weighted study (not pictured) showed high signal diffusely within both masses. Gadolinium-enhanced axial and coronal studies showed that the pontine mass compressed the fourth ventricle and extended rostrally to the hypothalamus but spared the optic chiasm (Figs 3, 4). There was no hydrocephalus. At the same time, an axial CT with contrast material demonstrated only faint enhancement in the pons (Fig 5). In the cerebrospinal fluid, protein content was 81 mg/dl and glucose, 56 mg/dl; there were 2 white blood cells per mm 3 and cytology showed no malignant cells. Transsphenoidal adenectomy led to the pathological diagnosis of chromophobe adenoma; stains for GH, ACTH, and prolactin were negative.Since the brainstem lesions noted on MRI were asymptomatic, they were not treated. Six months after surgery, the patient noted paresthesias of the right hand and foot and a diagnostic procedure was performed. Differential DiagnosisDr Keith A. Sanders: This man developed central DI at age 18 and over the next 15 years hypogonadism appeared_ Ultimately, a unilateral sensory disturbance was attributed to brainstem and hypothalamic abnormalities demonstrated...

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“…The big concave defect in the body of the left lateral ventricle was caused by the meningioma. Note also non-filling of the posterior part of the third ventricle, considered in the beginning as incidental itary adenoma appearing with other tumors [28,[38][39][40][41][42], and three other coupled tumors [43,45], altogether 53 cases of multiple primary intracranial tumors of diverse origin.…”

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confidence: 99%

Multiple intracranial tumors of diverse origin: Report of a case with review of literature

Sahar¹,

Streifler²

1966

Minim Invasive Neurosurg

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Multiple primary intracranial tumors

Cited by 12 publications

References 0 publications

Unusual coexistence of an epidermoid cyst with an atypical meningioma: Case report and review of the literature

Unusual coexistence of an epidermoid cyst with an atypical meningioma: Case report and review of the literature

Progressive Brainstem Disease in a 32‐Year‐Old Man with a Pituitary Adenoma and Longstanding Diabetes Insipidus

Multiple intracranial tumors of diverse origin: Report of a case with review of literature

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