Multiple primary cancers in extracolonic sites with colorectal cancer

Lee, Seung–Hyun; Ahn, Byung-Kwon; Baek, Sun‐Yong

doi:10.1007/s00384-008-0583-0

Cited by 19 publications

(17 citation statements)

References 10 publications

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“…Our data showed that GC was the most frequently associated cancer in patients with CRC both synchronously and metachronously, consistent with previous reports [9,10,[15][16][17][18][19].…”

Section: Resultssupporting

confidence: 93%

Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: Incidence of gastric cancer with colorectal cancer patients may be higher than previously recognized.

Kato

Suzuki

Muto

et al. 2014

JCO

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Background: Improvement in the prognosis of colorectal cancer (CRC) patients has led to increasing occurrences of multiple primary malignancies (MPMs) alongside CRC but little is known about their characteristics. This study was undertaken to clarify the clinical and pathological features of MPMs, especially those at extra colonic sites, in patients with CRC. Methods: We reviewed 1,111 patients who underwent operations for primary sporadic CRC in Saitama Medical Center, Jichi Medical University between April 2007 and March 2012. Two patients with familial adenomatous polyposis, one with hereditary non-polyposis colorectal cancer, two with colitic cancer, and any patients with metastasis from CRC were excluded. We compared the clinicopathological features of CRC patients with and without MPMs. As a control, we used a database compiled of patients with gastric cancer (GC) detected by mass screening performed in the Saitama Prefecture in Japan 2010 and compared these with CRC patients with synchronous GC. Results: Multiple primary malignancies at extracolonic sites were identified in 117 of 1,111 CRC patients (10.5%). The median age was 68 (range, 29 to 96) versus 71 (50 to 92) (P < 0.001). The incidence of GC (44.4% (52 of 117)) was the highest of all MPMs. All CRC patients with GC were older than 57 years. Synchronous GC was detected in 26 patients. By contrast, out of 200,007 screened people, 225 people were diagnosed as having GC in the Saitama Prefecture. The age-standardized incidence of synchronous GC in CRC patients was significantly higher (0.53%) than in the control group (0.03%) (odds ratio, 18.8; 95% confidence interval, 18.6 to 19.0; P < 0.001). Conclusion: Patients with CRC who were older than 50 years preferentially developed GC synchronously and metachronously. Thus, this patient group should undergo careful perioperative screening for GC.

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“…Our data showed that GC was the most frequently associated cancer in patients with CRC both synchronously and metachronously, consistent with previous reports [9,10,[15][16][17][18][19].…”

Section: Resultssupporting

confidence: 93%

Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: Incidence of gastric cancer with colorectal cancer patients may be higher than previously recognized.

Kato

Suzuki

Muto

et al. 2014

JCO

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“…The reported incidence of multiple primary cancers in extracolonic sites among CRC patients range from 2.4% to 8.7%. In this regard, the the most common extracolonic site of synchronous multiple primary cancers among CRC patients is stomach (Asia) and lung/breast (Europe) [4].…”

Section: Discussionmentioning

confidence: 99%

Synchronous mucinous colonic adenocarcinoma and multiple small intestinal adenocarcinomas: report of a case and review of literature

Corvino

Radice

et al. 2015

Clinical Imaging

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“…In our previous study, the incidence of multiple primary cancers in patients with colorectal cancer was 3.0%. The most common extra-colonic site of the multiple primary cancers among colorectal cancer patients (1.6%) was the stomach [4]. …”

Section: Discussionmentioning

confidence: 99%

BRAF mutation in multiple primary cancer with colorectal cancer and stomach cancer

Lee

Ahn

Baek

et al. 2013

Gastroenterology Report

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Aims: Recently, BRAF mutation testing has been introduced as a marker in differentiating Lynch syndrome from sporadic colorectal cancers or in predicting colorectal cancers with worse prognosis. Individuals with hereditary predisposition to cancer development are at an increased risk of developing multiple primary cancers. The purpose of this study is to identify mutation in the BRAF gene in multiple primary cancers with colorectal cancer and stomach cancer.Methods: BRAF mutation was analysed in 45 patients with colorectal cancer and stomach cancer, synchronously or metachronously.Results: Mean age was 64.07 years (range: 47–83 years). For the colorectal cancer, tumors were located at the sigmoid colon in eight patients (17.8%) and at the rectum in 22 patients (48.9%). Twenty-three patients (51.1%) had synchronous cancer. Four patients (8.9%) had family members with cancer. BRAF mutation was identified in three patients (6.7%). All three of these patients had metachronous cancers. The colorectal cancers were located in the sigmoid colon (1 patient) and the rectum (2 patients).Conclusions: BRAF mutation rate was low in the multiple primary cancer with colorectal cancer and stomach cancer. With only BRAF gene study, it was not possible to identify any correlation with family history of colorectal cancer. Further study means considering other genes – MSI, MSH2, MLH1, MSH6.

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Multiple primary cancers in extracolonic sites with colorectal cancer

Abstract: Gastric cancer is the most common synchronous multiple primary cancers occurring concomitantly with colorectal cancers. Careful preoperative screening is necessary for the detection of multiple primary cancers in extracolonic sites in patients with colorectal cancers.

Cited by 19 publications

References 10 publications

Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: Incidence of gastric cancer with colorectal cancer patients may be higher than previously recognized.

Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: Incidence of gastric cancer with colorectal cancer patients may be higher than previously recognized.

Synchronous mucinous colonic adenocarcinoma and multiple small intestinal adenocarcinomas: report of a case and review of literature

BRAF mutation in multiple primary cancer with colorectal cancer and stomach cancer

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