Multiple primary cancer in the female genital system

Chai, Wei; Gong, Fengyan; Zhang, Wenlei; Wen, Yan; Cui, Lifeng

doi:10.1097/md.0000000000008860

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…However, this patient did not have multiple primary carcinoma, as generally defined, but a collision carcinoma. The distinction is that the former refers to two pathological types of tumor found simultaneously or successively in different sites in the same patient, 11 whereas the latter means that two tumor tissues are close to each other, with no transitional changes or mixing between them. 12 According to our macroscopic assessment and pathological and immunohistochemical results of the postoperative specimen, the findings in our patient were consistent with the diagnosis of collision carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Collision carcinoma of endometrial adenocarcinoma and primary serous fallopian tube carcinoma: a case report

et al. 2020

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Collision carcinoma is a rare malignancy that generally occurs in cervical, esophageal, pulmonary, and squamous cell cancers. Few studies have been reported involving endometrial adenocarcinoma and fallopian tube carcinoma. We reported the case of a 58-year-old woman who presented because of irregular vaginal bleeding for more than 1 month. Cervical biopsy suggested moderately differentiated cervical adenocarcinoma, and the patient underwent radical hysterectomy under general anesthesia. However, postoperative pathology and immunohistochemical results indicated a collision tumor comprising endometrial adenocarcinoma (grade I) and primary serous fallopian tube carcinoma. According to the treatment principle of multiple primary tumors, a regimen of paclitaxel combined with carboplatin was administered. The patient also underwent local pelvic radiotherapy to treat lymph node metastasis. One month later, the patient developed brain metastases and died.

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Section: Discussionmentioning

confidence: 99%

Collision carcinoma of endometrial adenocarcinoma and primary serous fallopian tube carcinoma: a case report

et al. 2020

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“…For MPC, radical excision of the tumors is preferred. When faced with that for recurrent or metastatic malignant tumors, the prognosis for MPC is comparatively more favorable (31,32).…”

Section: Discussionmentioning

confidence: 99%

Synchronous primary sigmoid colon cancer and primary thyroid cancer followed by a malignant tumor of the kidney: Case report of multiple primary cancer and review of the literature

Pan

Gao

et al. 2018

Oncol Lett

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Multiple primary cancer (MPC) is relatively rare. With the development of diagnostic and anti-cancer therapeutic techniques, the incidence of MPC is rising annually. However, the incidence of triple or quadruple cancers in a single patient remains low. In this report, the case of a 58-year-old male with triple malignant cancer is outlined. Synchronous sigmoid colon cancer and thyroid cancer were diagnosed in May 2015; on subsequent re-examination, metastasis to the liver and a malignant kidney tumor were also identified. The diagnosis was established via computed tomography (CT), Positron emission tomography-CT (PET-CT) and other laboratory examination results, including analysis of tumor markers and liver function, and was confirmed by pathological diagnosis. The patient underwent radical surgery and standardized chemotherapy. Through literature review, the definition, characteristics, classification, incidence, possible causes of and treatment strategies for MPC were more clearly understood. In addition, immunohistochemical staining of integrin αvβ6 was performed on patient tissue specimens, where integrin αvβ6 expression was confirmed in cancer of the colon, thyroid and liver, as a result of colonic metastasis. Therefore, the involvement of integrin αvβ6 in the malignant progression of MPC was hypothesized, which may aid the investigation of MPC etiology in the future.

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Synchronous primary malignancy of colon cancer and mantle cell lymphoma: A case report

Liao

Song

et al. 2021

Open Medicine

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Multiple primary malignancies in a single patient are relatively rare; however, the frequency of this has increased significantly in recent decades. Here, we retrospectively reported an unusual case of a 70-year-old man who was admitted to the hospital with mantle cell lymphoma (MCL) and colon cancer and aimed to explore measures to reduce missed diagnosis. Based on the data, the investigation of the related literatures, colonoscopy examination, and abdominal computed tomography (CT) scan were conducted for the detection of colon cancer. Following this, a precise diagnosis of MCL was confirmed by immunohistochemistry and bone marrow biopsy, which were performed to analyze the clinical characteristics and essentials for the diagnosis and differential of the disease. The results of colonoscopy showed that the patient had colon cancer, while the abdominal CT scan demonstrated colon cancer accompanied by multiple lymphadenopathy throughout the entire body. Besides, the results of immunohistochemistry confirmed that the patient suffered from MCL. The bone marrow biopsy revealed the active hematopoietic tissue hyperplasia but no tumor issue involvement in the bone marrow. In conclusion, our study combined the analysis and summary of the diagnosis and treatment of the colon cancer with MCL to provide clinical guidance for the rare multiple primary malignancy.

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Multiple primary cancer in the female genital system

Cited by 4 publications

References 7 publications

Collision carcinoma of endometrial adenocarcinoma and primary serous fallopian tube carcinoma: a case report

Collision carcinoma of endometrial adenocarcinoma and primary serous fallopian tube carcinoma: a case report

Synchronous primary sigmoid colon cancer and primary thyroid cancer followed by a malignant tumor of the kidney: Case report of multiple primary cancer and review of the literature

Synchronous primary malignancy of colon cancer and mantle cell lymphoma: A case report

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