Multiple primary cancer in adults (MPCA)

Abstract

16027 Background: As a result of the improvement in oncological treatments, MPCA could arise as a more frequent problem in Public Health. The purpose of this retrospective review was to estimate both the incidence and medical features of MPCA pts treated at the Instituto Oncológico Henry Moore (IOHM). Methods: We analyzed 17,100 medical charts from our database since 1987 and identified 378 MPC (2,21%). Then we retrieved data over the last eight years (1997–2005). Those pts with at least two second primary tumors were included in this analysis. They were categorized as synchronous (second tumor diagnosis within the first six months from the first one) and metachronous (all the remaining). Pts with skin cancer different from melanoma were excluded. Results: One hundred and seventy eight (M:73; F:105) out of 8,500 cancer pts (2.09%) had at least two primary cancers. Median age was 59, 64 and 68 yo at the moment of the first, second and third diagnosis, respectively. In 138 (78%) pts, the diagnosis of the second cancer was suspected by clinical findings, while in 40 (22%) pts, it was discovered because of medical screening in an otherwise asymptomatic pt. (See Table below) The most frequent site combination was breast-breast (n = 21). A total of 57 pts (32%) had a family history of oncologic diseases. With a median follow-up of 31 mo (range: 0,57–311) after the second cancer diagnosis, 127 pts are still alive (71,35%) and 51 (28,65%) are dead. Conclusions: In the last eight years, 178 (2.09%) pts had developed MPC, being breast, prostate, colon and lung the most frequent (first and later) localizations, and breast-breast the most frequent site combination. The so-called “screening effect” seems to have a low impact on the studied population. [Table: see text] No significant financial relationships to disclose.

Gastric mucosa-associated lymphoid tissue lymphoma in the context of multiple primary neoplasms

“…Multiple primary cancers may be determined by three principal and non-mutually exclusive factors: shared etiologic exposure, familial cancer syndromes or other genetic susceptibility factors, and prior cancer treatment. 10 With the exception of a positive family history – in one series, 32% of multiple primary cancer patients had a family history of oncologic diseases 7 – our patient had none of these factors. Tobacco use is one of the major causes of multiple primary cancers, but it is mostly associated with tumors of the lungs and upper aerodigestive tract, 10 and H. pylori seropositivity does not appear to be associated with lung cancer.…”

“…While some authors state that synchronous tumors occur within two months of each other, and a metachronous tumor occurs more than two months after the initial cancer diagnosis, 6 others would classify malignancies as synchronous if the interval between their diagnoses is less than or equal to six months, and metachronous when tumors occur more than six months apart. 2 , 7 , 8 …”

Synchronous Gastric Adenocarcinoma and Diffuse Large B-Cell Lymphoma in the Pelvis: A Rare Case Presentation

“…Inaba et al linked the treatment of primary gastric lymphoma, especially DLBCL, with an increased risk for developing gastric adenocarcinomas [ 7 ]. Moreover, an Argentine study concluded that 32% of MPC patients had a family history of cancer [ 8 ]. Indeed, our patient had also a significant family history of cancer (both father and brother died of malignancies).…”

Five Cases Report of Solid Tumor Synchronously with Hematologic Malignancy

“…It was reported whether or not genetic defects involving the mismatch repair system constituted an important risk factor in patients with MPC [ 7 ]. An Argentine research group found 32% of MPC patients had a family history of oncologic diseases [ 8 ]. In this report, we found only one patient (case 5, accounting for 20%) who carried this genetic tendency.…”