Multiple Primary Acral Melanomas in African-Americans: A Case Series and Review of the Literature

Hutcheson, Angela C. S.; McGowan, Joseph W.; Maize, John C.; Cook, J.

doi:10.1111/j.1524-4725.2007.33000.x

Cited by 23 publications

(23 citation statements)

References 84 publications

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“…A recent systematic review of the literature [2], and corroborated in a case-control study in our population [6], revealed that AM is more prevalent in individuals in the fifth to seventh decades of life [4]. Surprisingly, patients reported herein are under 40 years old.…”

Section: Discussionmentioning

confidence: 71%

“…To the best of our knowledge, there is just one other report of multiple primary AM presented in 4 African-American patients [4], the 2 cases reported herein being the first series in Caucasians.…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of melanoma on the hands and feet is 3-15% of all cutaneous melanomas in fair-skinned populations and varies considerably from country to country [3,4,5]. Although hand melanoma accounted for a small proportion of cutaneous melanoma in all populations, foot melanoma was the most common type in populations with pigmented skin [2].…”

Section: Introductionmentioning

confidence: 99%

“…Melanoma in an acral location deserves special consideration; it seems to have a poorer prognosis than cutaneous melanoma in other sites, in part as a result of the delay in diagnosis, but probably also due to a particular aggressiveness of the acral lentiginous melanoma (ALM) subtype [2,3,4]. The incidence of melanoma on the hands and feet is 3-15% of all cutaneous melanomas in fair-skinned populations and varies considerably from country to country [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

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Multiple Primary Acral Melanomas in Two Young Caucasian Patients

et al. 2014

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Background: Acral melanoma (AM) is still one of the most poorly studied melanomas. It generally presents beyond the fifth decade of life and usually is a BRAF wild-type melanoma. Objective: To report the first cases of multiple primary AM in Caucasians. Methods: Clinical, dermoscopic, pathological and molecular profiles. Results: A healthy 34- year-old male presented an in situ subungual melanoma on his finger, and 22 months later a fast-growing nodular melanoma appeared in an existing nevus on the sole. Both melanomas carried the V600E BRAF mutation. A 19-year-old female patient presented 2 in situ melanomas on different parts of her left foot within a 6-year period of time. The patients have neither familiar melanoma nor germline mutations in CDKN2A/CDK4 genes. Conclusion: Multiple AM in Caucasians is very rare. BRAF mutations are possible, especially in a high-risk set of patients with multiple nevi. Specific acral examination must be recommended since AM still suffers delayed detection.

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Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multiple Primary Acral Melanomas in Two Young Caucasian Patients

et al. 2014

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“…6 Numerous volar melanotic macules, so called acral melanosis, has been reported in association with primary acral melanomas. 5,11 Specific genetic defects are involved in the pathogenesis of melanotic macules as certain familial lentiginoses 56 can exhibit volar melanotic macules such as Peutz-Jegher syndrome, Leopard syndrome, and Carney syndrome (also known as Lentigines, Atrial myxomas, Mucocutaneous myxomas, and Blue nevi (LAMB) or Nevi, Atrial myxoma, Myxoid neurofibroma, and Endocrine disorders/Ephelides (NAME) syndrome). [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] In the familial setting, volar macules are acquired during childhood and found commonly on the fingers as opposed to idiopathic cases, which affect middle-aged and older adults and are found more commonly on the soles and palms.…”

Section: Discussionmentioning

confidence: 99%

Volar Melanotic Macules in a Gardener: A Case Report and Review of the Literature

Blossom

Altmayer²,

Jones³

et al. 2008

The American Journal of Dermatopathology

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Volar melanotic macules are asymptomatic, tan-brown to brownish-black macules found on the palms, fingers, soles, and/or toes of dark-skinned individuals and are infrequently reported in light-skinned individuals. Herein, we report the acquisition of multiple, brownish-black volar digital macules in a 63-year-old white woman and avid gardener that were noted after the onset of pruritic, chronic hand dermatitis over a 10-month period. She was healthy without any medical conditions or medications. No family history of intestinal polyposis or mucosal melanosis existed. At presentation, she had less than 20 brownish-black, 2- to 10-mm irregular macules over the volar aspect of the thumbs and index fingers, left greater than right hand, associated with erythema, scale, and a negative potassium hydroxide examination. In addition, she had melanotic macules of her lips, buccal mucosa, and conjuctiva. No nail or anogenital macules were found. Biopsy demonstrated a region of epidermal hyperplasia, hyperkeratosis, and interface dermatitis associated with melanophages and sparse lymphocytic infiltrate. Melanin staining revealed diffuse pan-epidermal hypermelanization, dermal melanin, and dendritic melanocytes, which expressed HMB-45. After 1-year follow-up and treatment with topical corticosteroid, the volar macules have faded to tan brown. Based on the location, avocation, and coexisting mucosal melanotic macules, an irritant phytodermatitis with postinflammatory hyperpigmentation was diagnosed in the setting of Laugier-Hunziker syndrome-a disorder denoted by macular hyperpigmentation of nail, volar, and/or mucosal surfaces in healthy adults. Volar melanotic macules can also complicate 5-flourouracil therapy, tinea pedis, and other inflammatory disorders; be associated with acral melanomas; or represent a cutaneous manifestation of systemic disease such as Addison disease, Peutz-Jegher syndrome, Leopard syndrome, Carney syndrome, AIDS, and neurofibromatosis.

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Molecular Signatures of Highly Malignant Melanoma Stem Cells

Rasheed

2008

Cancer Stem Cells

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Multiple Primary Acral Melanomas in African-Americans: A Case Series and Review of the Literature

Cited by 23 publications

References 84 publications

Multiple Primary Acral Melanomas in Two Young Caucasian Patients

Multiple Primary Acral Melanomas in Two Young Caucasian Patients

Volar Melanotic Macules in a Gardener: A Case Report and Review of the Literature

Molecular Signatures of Highly Malignant Melanoma Stem Cells

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