Multiple Pregnancies and Gestational Hypertensive Diseases

Corominas, A; Balconi, Silvia; Ortiz, Maria; Parodi, Mauricio Castro; Damiano, Alicia E.

doi:10.1016/j.placenta.2019.06.328

Cited by 1 publication

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“…In 2016, Elmas et al [ 20 ] conducted a study to determine the correlation between hypertension and plasma UA and its predictive utility in severe preeclampsia. Most studies conclude that uric acid is a useful predictor of hypertensive disorders of pregnancy [ 19 , 21 ] but others hold the view that SUA concentrations appear to be neither minimally predictive nor non-predictive in monitoring pregnancy hypertension [ 22 ]. Hawkins et al [ 23 ] found that elevated SUA levels in pregnant women with HDP had no obvious effect on maternal outcome.…”

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confidence: 99%

The Impact of Serum Uric Acid Levels on Hypertensive Disorders of Pregnancy in Advanced Maternal Age Women: A Retrospective Study from a Single Center in China

Luo,

Huang,

Zhuang

et al. 2024

Med Sci Monit

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Background In many countries, including China, women are delaying pregnancy until later in life; therefore, hypertensive disorders of pregnancy (HDP) are increasing. This retrospective study from a single center in China aimed to evaluate the association between serum uric acid (SUA) levels and HDP in 288 women of advanced maternal age >35 years. Material/Methods A total of 780 pregnant women of advanced maternal age were included in the study – 288 were had HDP (including gestational hypertension and preeclampsia) and 492 had normal blood pressure using 1: 2 (84: 168) propensity score matching. SUA (collected before 20 weeks’ gestation) and HDP incidence in advanced maternal age women were assessed using multivariate logistic modeling and 3 propensity score-based methods. Results Median patient age was 37 years. The risk of developing HDP increases with higher SUA (30.19% vs 13.65%, P <0.001). In the PS-matched cohort, the risk ratio (OR) for HDP with high uric acid after adjusting for confounders was 2.88 (95% CI: 1.44–5.75, P =0.0027). It has been demonstrated that high uric acid is strongly associated with HDP incidence in both the crude population (OR=3.43, 95% CI: 2.01–4.66, P <0.0001) and the weighted cohorts (OR=3.62, 95% CI: 2.81–4.66, P <0.0001). As a successive variable, after adjusting for the clinical confounders, a 1-SD increase in SUA was related to a 135% increased risk of HDP (OR=2.35; 95% CI: 1.57–3.50; P <0.0001) based on the fully adjusted model. There were similar conclusions in the sensitivity analysis. Conclusions There was a significant association between SUA and HDP in women of advanced maternal age, supporting the importance of early detection of SUA in pregnant women.

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