Colitis due to cytomegalovirus (CMV) in immunocompetent patients is an infrequent occurrence and is associated with medical conditions that cause immunodepression, such as diabetes mellitus, prolonged residence in the intensive care unit, autoimmune diseases, organ failure, etc. The immune imbalance noticed in patients with severe coronavirus disease 2019 (COVID-19) can lead to co-infection or reactivation of CMV. But CMV colitis following a recent COVID-19 is extremely rare. We present a case of an elderly female, who recently had COVID-19 and was evaluated for nausea vomiting and abdominal pain. Colonoscopy showed severe inflammation and congested mucosa and histopathological analysis of the biopsy specimen confirmed the diagnosis of CMV colitis. The patient had an excellent response to oral ganciclovir therapy. This case highlights the importance of suspecting CMV colitis in patients with recent COVID-19 presenting with nonspecific symptoms, such as in our case of nausea, vomiting, and abdominal pain and pancolitis on imaging, as early diagnosis is the key to improved outcomes.