Multiple platelet-rich plasma preparations can solubilize freeze-dried chitosan formulations to form injectable implants for orthopedic indications

Zadeh, Leili Ghazi; Chevrier, Anik; Lamontagne, Martin; Buschmann, Michael D.; Hoemann, Caroline D.; Lavertu, Marc

doi:10.3233/bme-191058

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Chitosan and its derivatives possess notable characteristics such as low immunogenicity, biodegradability, biocompatibility, and antimicrobial activity, making them ideal biomaterials for wound healing applications (43). The polysaccharide nature of chitosan contributes to its ability to stimulate increased activity in macrophages, polymorphonuclear leukocytes, and fibroblasts, thereby enhancing granulation and tissue organization (44). As chitosan slowly degrades into Nacetyl-D-glucosamine, it facilitates the proliferation of fibroblasts, supports collagen deposition, and stimulates the synthesis of hyaluronic acid at the wound site.…”

Section: Chitosan In the Inflammatory And Proliferation Phase Of Woun...mentioning

confidence: 99%

The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review

Erlyn,

Irfannuddin,

Murti

et al. 2024

JKB

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Hemostasis is an emergency medical treatment to reduce pain and patient mortality, therefore research is being developed to find effective hemostasis. The utilization of natural materials for hemostasis and wound healing is rapidly expanding, including chitosan found in shell extracts. Chitosan is obtained from chitin found in the soft shells of marine animals such as squid, shrimp, and crabs, or from hard shells such as clams, crabs, and lobsters. Chitosan offers advantages such as good biodegradability, biocompatibility, and non-toxicity, and has been widely used in biomedical, chemical, food, and cosmetic industries. This literature review aims to investigate the potential of shell extracts, particularly the characteristics of chitosan, in wound healing across hemostasis, inflammation, proliferation, and remodeling stages. The study results indicate that extracts from shells containing chitosan exhibit varying characteristics in terms of molecular weight and degree of deacetylation. Chitosan with higher molecular weight and degree of deacetylation tends to yield better outcomes in hemostasis and wound healing. The material is effective in reducing antithrombin, enhancing blood clotting processes, and aiding clot formation. Increased molecular weight contributes to stimulating various cytokines, such as TNF-α, TGF-ß1, and FGF2, which play a key role in the wound healing process. Additionally, higher degree of deacetylation chitosan is effective in stimulating fibroblast proliferation. Chitosan also influences VEGF in inducing angiogenesis and enhancing neovascularization in bone healing. Chitosan from shell extracts with certain molecular weight characteristics and degree of deacetylation has the potential to be the material of choice for accelerating hemostasis and wound healing.

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Section: Chitosan In the Inflammatory And Proliferation Phase Of Woun...mentioning

confidence: 99%

The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review

Erlyn,

Irfannuddin,

Murti

et al. 2024

JKB

View full text Add to dashboard Cite

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Chitosan–Platelet Interactions

Hoemann

Rivard

2021

Advances in Polymer Science

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Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study

2021

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The purpose of this study was to assess the safety and efficacy of chitosan–platelet-rich plasma (PRP) hybrid implants used as an adjunct to surgical rotator cuff repair in a pivotal Good Laboratory Practice (GLP)-compliant study. The infraspinatus tendon was transected in 48 skeletally mature ewes and repaired with a transosseous-equivalent (TOE) technique. In the two treatment groups, a chitosan–PRP solution was injected at the footprint between the tendon and the bone and on top of the repaired site (2 mL or 3 mL doses, n = 12 per group). To further assess chitosan safety, a chitosan–water solution was injected at the same sites (3 mL, n = 12). Outcome measures included Magnetic Resonance Imaging (MRI) assessment and clinical pathology at 3 months and 6 months and histopathology at 6 months. The tendon gap was decreased at 3 months on MRI images and certain histopathological features were improved at 6 months by chitosan–PRP treatment compared to controls. The group treated with chitosan–water was not different from controls. Chitosan–PRP treatment induced no negative effects in the sheep, which suggests high safety. This study provides further evidence on the safety and efficacy of chitosan–PRP for rotator cuff repair augmentation, which could eventually be used in a clinical setting.

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Multiple platelet-rich plasma preparations can solubilize freeze-dried chitosan formulations to form injectable implants for orthopedic indications

Cited by 3 publications

References 29 publications

The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review

The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review

Chitosan–Platelet Interactions

Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study

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