Multiple Physically Cross-Linked F127−α-CD Hydrogels: Preparation, Sol–Gel Transformation, and Controlled Release of 5-Fluorouracil

Li, Peihong; Zhang, Chunyu; Li, Rui; Qu, Lijie; Dai, Xueyan; Sui, Yanlong; Hou, Jiazi

doi:10.1021/acsabm.8b00698

Cited by 11 publications

(10 citation statements)

References 32 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the stacked-like structures, some aggregation zones were found (yellow arrows). According to Peihong’s study [ 23 ], we could assume that the aggregation zone consists of a firmed 3D structure formed by α-CD/mPEG and α-CD/PEO by the host-guest reaction. In addition, we observed that GEL-CP has a more complex internal structure than GEL-F through the FE-SEM image.…”

Section: Resultsmentioning

confidence: 99%

“…In most studies, hydrogel physical properties can be determined by the concentration of α-CD, which is due to the higher concentration of α-CD acting as a host molecule, increased entrapment with guest molecules, and more crosslinking sites. In particular, F127 is actively used as a temperature-sensitive hydrogel, but there has been interest in its high utilization as a host-guest reactive hydrogel using α-CD [ 23 ]. In our study, F127-α-CD was formed under conditions similar to existing research, and the release of BSA protein showed similar patterns.…”

Section: Discussionmentioning

confidence: 99%

“…Hydrogels made through host–guest reaction are biocompatible compared to cross-linked hydrogels since they do not use toxic chemical cross-linker and are not exposed to UV rays. In addition, the gel structure transitions to a sol when shear forces are applied and then forms a gel again after a time [ 23 ]. Additionally, the thixotropic property of supramolecular hydrogels has an advantage in being used as a material for injections and 3D printing.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sulfur(VI) Fluoride Exchange (SuFEx)-Mediated Synthesis of the Chitosan-PEG Conjugate and Its Supramolecular Hydrogels for Protein Delivery

et al. 2021

View full text Add to dashboard Cite

Supramolecular hydrogels are considered promising drug carriers in the tissue engineering field due to their versatile nature. Chitosan hydrogels without chemical cross-linkers have low cytotoxicity and good delivery capacity; however, they have lower mechanical properties for injectable hydrogel usage. In this study, we developed novel chitosan derivatives via click chemistry for fabricating supramolecular hydrogels with higher mechanical strength under mild conditions. The chitosan derivative was successfully synthesized by a sulfur fluoride exchange reaction, and the synthesized chitosan-mPEG/Pluronic-F127 (CS-mPEG/F127) interacted with α-cyclodextrin (α-CD) to form a supramolecular hydrogel via a host-guest reaction. The gelation dynamics, hydrogel properties, and bovine serum albumin (BSA) release could be modulated by the concentration ratio of chitosan-mPEG and F127. This supramolecular hydrogel is a promising protein releasing carrier candidate for long term regeneration therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sulfur(VI) Fluoride Exchange (SuFEx)-Mediated Synthesis of the Chitosan-PEG Conjugate and Its Supramolecular Hydrogels for Protein Delivery

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This represents a major disadvantage for employment in biomedicine, and consequently, significant research effort has been devoted to work around this problem. Approaches include the chemical modification and/or chemical cross‐linking of Pluronics, chain extension to form multiblock poly(ethylene oxide)‐poly(propylene oxide) (PEO‐PPO) polymers, or the generation of blends with other polymers . Epoxides with longer alkyl side chains have also been employed for a similar purpose .…”

Section: Introductionmentioning

confidence: 99%

“… The employment of high molar mass polymer with long, terminal PPO‐blocks was expected to result in a significant increase of the mechanical strength of the corresponding hydrogel. At the same time these chemically conservative manipulations are proposed not to infringe on the very beneficial biocompatibility generally observed for Pluronics, supposedly in contrast to the more drastic changes imparted by other approaches to improve mechanical properties, such as using chemically different monomers or chemical cross‐links . Nonetheless, it has been demonstrated that small changes to the Pluronic structure can have a sizable impact on applicability in biomedicine, so the same must be expected for “reverse Pluronics.”…”

Section: Introductionmentioning

confidence: 99%

Controlled Synthesis of “Reverse Pluronic”‐Type Block Copolyethers with High Molar Masses for the Preparation of Hydrogels with Improved Mechanical Properties

Markus

Bruckner

Naumann

2020

Macro Chemistry & Physics

View full text Add to dashboard Cite

for forming self-assembled, micellar structures, [2] these polymers are also increasingly employed for advanced technologies such as drug-delivery and tissue engineering, [3][4][5][6][7] or as structure-directing agents for the preparation of mesoporous materials. [8][9][10] For medical applications specifically, Pluronic-type polyethers are of interest because of their a) commercial availability in a variety of different molecular weights and EO/PO ratios, b) biocompatibility and non-toxic properties, and c) ability to form hydrogels. [11] For the latter, the reverse thermo-responsive behavior of these amphiphilic polyethers is exploited. Thus, at room temperature, aqueous solutions typically display a low viscosity, while an increase of temperature yields rapid gelation. If parameters are chosen correctly, syringe-injectable systems can thus be realized, which swiftly gel at body temperature. [4] In principle, the gels can then be used to continuously release drugs or to serve as scaffolds for cell-growth. [11] Unfortunately, however, hydrogels derived from these triblock copolymers show only limited stability and require relatively high polyether loadings of >15 wt%; the material is highly permeable, erodes quickly, and is overall mechanically weak. [12,13] This represents a major disadvantage for employment in biomedicine, and consequently, significant research effort has been devoted to work around this problem. Approaches include the chemical modification and/or chemical cross-linking of Pluronics, [14][15][16][17] chain extension to form multiblock poly(ethylene oxide)poly(propylene oxide) (PEO-PPO) polymers, [18,19] or the generation of blends with other polymers. [20][21][22][23] Epoxides with longer alkyl side chains have also been employed for a similar purpose. [24] In general, the development of strategies to enhance the mechanical robustness of hydrogels is an intensely studied field of research. [25] For this contribution, a simpler strategy was envisioned which actually leaves the typical constitution of Pluronics intact but exploits the thermodynamics of micellization to result in more robust hydrogels. Thus, first, based on the finding that the polyether molar mass clearly scales with the viscosity/ storage modulus of the corresponding hydrogel, [18] PEO-PPO copolymers with exceptionally high molecular weights were targeted, well beyond the scope of commercial availability (up to 13 000 g mol −1 for F127 or F98). This was enabled by recent progress in polymerization catalysis, [26,27] which makes Hydrogels based on Pluronics (EO n/2 -PO m -EO n/2 , EO = ethylene oxide, PO = propylene oxide) have been frequently investigated, yet key limitations still remain, including a propensity for quick erosion and insufficient mechanical robustness. This issue can be alleviated by creating "reverse Pluronics" (PO n/2 -EO m -PO n/2 ), which is proposed to enable the formation of physical cross-links via a micellar network. Until recently, however, efforts in this direction were aggravated by synthetic diffic...

show abstract

Rheological Tunable Magnetic Fluids with Long‐Term Stability

Wang

Bisoyi

et al. 2022

Small

View full text Add to dashboard Cite

has become a hot topic of magnetic materials with extremely high value for fundamental studies and applications. [8][9][10] As a new type of functional material, magnetic fluid is a colloidal dispersion in which the magnetic particles exist uniformly and stably in the carrier fluid. [11][12][13] Due to the outstanding fluidity, mass transfer and heat transfer properties, and solid-like properties in strong magnetic fields, a series of magnetic fluids such as magnetorheological fluids have been fabricated and widely used in the fields of medical treatment, sealing, damping, ultra-precision working, and processing media, etc. [14][15][16][17][18][19][20][21][22][23] However, the large density mismatch between the magnetic particles and the carrier fluid used in the magnetic fluids leads to serious particle sedimentation problems under gravity, which hinders the application of these magnetic materials. [24][25][26][27] One main strategy is to modify or functionalize magnetic particles. Tuning the size and/or shape of the particles and coating the surface of the particles with polymers or inorganic materials have been proven as effective methods to improve the stability of magnetic fluids. [28][29][30][31][32] Another common method is to change the properties of the carrier fluid. Using sticky fluids, such as commercial grease, as the carrier fluid to replace traditional oil/water liquid matrix or introducing additives, such as carbon nanoparticles clay, carbon nanofibers, graphene oxide, or fumed silica particles, into the carrier fluid can endow the magnetic fluids with good suspension stability. [33][34][35][36][37][38][39] In addition, polymers such as rubber are used to completely replace the continuous phase of non-magnetic liquid to obtain magnetic elastomers, which are completely solid even in the environment without magnetic field. [40][41][42][43] It should be noted that most of these previous reported systems with high stability presented a relatively high off-state (i.e., no-field) viscosity, which impaired the magnetic response ability of magnetic particles inside the magnetic fluid. [27] However, the aggregation of magnetic particles to form chainlike structures under strong magnetic field is the key to realize the reversible change from a liquid-like viscous state to a solid-like elastic state of the magnetic liquid. [28,30] The magnetic particles with better stability always have weaker responses to strong magnetic fields and are difficult to aggregate to form chainlike structures to change the viscosity of the magnetic fluid, which Magnetic fluids have advantages such as flow ability and solid-like property in strong magnetic fields, but have to suffer from the tradeoff between suspension stability and flow resistance. In this work, a thermal/photo/ magnetorheological water-based magnetic fluid is fabricated by using oleic acid-coated Fe 3 O 4 (Fe 3 O 4 @OA) nanoparticles as the magnetic particles and the amphiphilic penta block copolymer (PTMC-F127-PTMC)-based aqueous solution as the carrier fluid. ...

show abstract

Multiple Physically Cross-Linked F127−α-CD Hydrogels: Preparation, Sol–Gel Transformation, and Controlled Release of 5-Fluorouracil

Cited by 11 publications

References 32 publications

Sulfur(VI) Fluoride Exchange (SuFEx)-Mediated Synthesis of the Chitosan-PEG Conjugate and Its Supramolecular Hydrogels for Protein Delivery

Sulfur(VI) Fluoride Exchange (SuFEx)-Mediated Synthesis of the Chitosan-PEG Conjugate and Its Supramolecular Hydrogels for Protein Delivery

Controlled Synthesis of “Reverse Pluronic”‐Type Block Copolyethers with High Molar Masses for the Preparation of Hydrogels with Improved Mechanical Properties

Rheological Tunable Magnetic Fluids with Long‐Term Stability

Contact Info

Product

Resources

About