One of the main challenges to upscale the fabrication of molecular devices is to achieve a mechanically stable device with reproducible and controllable electronic features, operating at room temperature 1,2. This is crucial because structural and electronic fluctuations can lead to significant changes in the transport characteristics at the electrode-molecule interface 3,4. In this study, we report on the realization of a mechanically and electronically robust graphene-based molecular junction. Robustness is achieved by separating the requirements for mechanical and electronic stability at the molecular level. Mechanical stability is obtained by anchoring molecules directly to the substrate, rather than to graphene electrodes, using a silanization reaction. Electronic stability is achieved by adjusting the π-π orbitals overlap of the conjugated head groups between neighbouring molecules. The molecular devices exhibit stable current-voltage (I-V) characteristics up to bias voltages of 2.0 V with reproducible transport features in the temperature range from 20 K to 300 K. To realize reliable graphene-based junctions, several issues exist to date and need to be addressed. First, graphene-based junctions have been reported to exhibit signatures similar to those of molecules, with gate-dependent resonance features, such as Coulomb blockade 5,6 , quantum interference 7 and Fabry-Perrot resonances 8. Second, connecting molecules to the graphene remains challenging due to the lack of control on the electrode geometry at the nanoscale 4,5,8-10. Achieving both mechanical stability and electrical reproducibility at the same time impose different requirements on the junction properties 3,11. Finding the proper balance between electronic and mechanical stability is therefore challenging. Weakly coupled π − π stacking is believed to be an appealing strategy to anchor molecules to the contact electrodes 3 , offering advantages such as high thermoelectric efficiency. However, this approach has been shown to lead to mechanically unstable junctions 12. Alternatively, molecules have also been bonded covalently to graphene, yielding mechanically stable junctions 10. However, transport through strongly coupled molecules is expected to be heavily influenced by the electrode geometry, edge termination and crystallographic structure, leading to a large variability in the shape of the current-voltage characteristics 3. Third, junction-to-junctions via molecular orbital gating. Nature nanotechnology 1 (2018).