Multiple pharmacological activities of Caesalpinia crista against aluminium-induced neurodegeneration in rats: Relevance for Alzheimer’s disease

Ravi, Sunil Kumar; Ramesh, B N; Mundugaru, Ravi; Vincent, Bruno

doi:10.1016/j.etap.2018.01.008

Cited by 31 publications

(21 citation statements)

References 64 publications

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“…Neurodegenerative diseases, such as AD, are morphologically featured by progressive loss of neurons in specific vulnerable regions of the central nervous system. The mechanisms of neurodegeneration is believed to be multifactorial which includes, mitochondrial dysfunction, oxidative stress, defective protein degradation and aggregation, genetic, environmental, and endogenous factors [44,45]. In the present study, exposure to d -gal and AlCl 3 readily led to significant morphological aberrations in the CA 3 sub-regions of the rat’s hippocampus.…”

Section: Discussionmentioning

confidence: 52%

Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus

Chiroma

Baharuldin

Taib

et al. 2019

IJMS

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD is characterised clinically by a progressive decline in cognitive functions and pathologically by the presence of neurofibrillary tangles (NFTs), deposition of beta-amyloid (Aβ) plaque and synaptic dysfunction in the brain. Centella asiatica (CA) is a valuable herb being used widely in African, Ayurvedic, and Chinese traditional medicine to reverse cognitive impairment and to enhance cognitive functions. This study aimed to evaluate the effectiveness of CA in preventing d-galactose/aluminium chloride (d-gal/AlCl3) induced AD-like pathologies and the underlying mechanisms of action were further investigated for the first time. Results showed that co-administration of CA to d-gal/AlCl3 induced AD-like rat models significantly increased the levels of protein phosphatase 2 (PP2A) and decreased the levels of glycogen synthase kinase-3 beta (GSK-3β). It was further observed that, CA increased the expression of mRNA of Bcl-2, while there was minimal effect on the expression of caspase 3 mRNA. The results also showed that, CA prevented morphological aberrations in the connus ammonis 3 (CA 3) sub-region of the rat’s hippocampus. The results clearly demonstrated for the first time that CA could alleviate d-gal/AlCl3 induced AD-like pathologies in rats via inhibition of hyperphosphorylated tau (P-tau) bio-synthetic proteins, anti-apoptosis and maintenance of cytoarchitecture.

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Section: Discussionmentioning

confidence: 52%

Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus

Chiroma

Baharuldin

Taib

et al. 2019

IJMS

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“…The selected natural plants which are used in this study reported having a number of pharmacological activities. Plants such as Alstonia scholaris, Picrorhiza kurroa, Swertia chirata, and Caesalpinia crista were primarily known for their anti-malarial anti-inflammatory, anti-allergic, hepatoprotective activities (Baliga, 2012 ; Kumar & Van Staden, 2015 ; Ravi et al, 2018 ; Verma et al, 2009 ). Zingiber officinale, Glycyrrhiza glabra, Pipper nigrum, Tinospora cordifolia, Allium sativum, and Allium cepa, is primarily known for analgesic antimicrobial, immunomodulatory and antioxidants properties.…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection

Maurya

Kumar

Bhatt

et al. 2020

Journal of Biomolecular Structure and Dynamics

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SARS-CoV-2 is the etiological agent of COVID-19 and responsible for more than 6 million cases globally, for which no vaccine or antiviral is available. Therefore, this study was planned to investigate the antiviral role of the active constituents against spike glycoprotein of SARS-CoV-2 as well as its host ACE2 receptor. Structure-based drug design approach has been used to elucidate the antiviral activity of active constituents present in traditional medicinal plants from Ayurveda. Further, parameters like drug-likeness, pharmacokinetics, and toxicity were determined to ensure the safety and efficacy of active constituents. Gene network analysis was performed to investigate the pathways altered during COVID-19. The prediction of drug–target interactions was performed to discover novel targets for active constituents. The results suggested that amarogentin, eufoliatorin, α-amyrin, caesalpinins, kutkin, β-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2. Most active constituents have passed the criteria of drug-likeness and demonstrated good pharmacokinetic profile with minimum predicted toxicity level. Gene network analysis confirmed that G-protein coupled receptor, protein kinase B signaling, protein secretion, peptidyl-serine phosphorylation, nuclear transport, apoptotic pathway, tumor necrosis factor, regulation of angiotensin level, positive regulation of ion transport, and membrane protein proteolysis were altered during COVID-19. The target prediction analysis revealed that most active constituents target the same pathways which are found to be altered during COVID-19. Collectively, our data encourages the use of active constituents as a potential therapy for COVID-19. However, further studies are ongoing to confirm its efficacy against disease.

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“…Cholinesterase inhibitors are the most frequently used medications among the drugs used for the treatment of AD (Ferreira‐Vieira et al, 2016; Giacobini, 2003). Some research reported that natural products‐derived bioactive compounds, such as methanolic extract of Caesalpinia crista (Ravi et al, 2018), Angelica Sinensis polysaccharides (Du et al, 2020), tea polyphenols (Mazumder & Choudhury, 2019), and linarin group (Pan et al, 2019) may raise the level of Ach via suppressing the activities of AchE and BuchE.…”

Section: Kmp Improves Memory In Ad Via Regulating Cholinergic Systemmentioning

confidence: 99%

Kaempferol as a potential neuroprotector in Alzheimer's disease

Nejabati

Roshangar

2022

Journal of Food Biochemistry

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Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, is largely associated with cognitive disability, amnesia, and abnormal behavior, which accounts for about two third of people with dementia worldwide. A growing body of research demonstrates that AD is connected to several factors, such as aberrant accumulation of amyloid‐beta (Aβ), increase in the hyperphosphorylation of Tau protein, and the formation of neurofibrillary tangles, mitochondrial dysfunction, and inordinate production of reactive oxygen species (ROS). Despite remarkable efforts to realize the etiology and pathophysiology of AD, until now, scientists have not developed and introduced medications that can permanently cease the progression of AD. Thus, nowadays, research on the role of natural products in the treatment and prevention of AD has attracted great attention. Kaempferol (KMP), one of the prominent members of flavonols, exerts its ameliorative actions via attenuating oxidative stress and inflammation, reducing Aβ‐induced neurotoxicity, and regulating the cholinergic system. Therefore, in this review article, we outlined the possible effects of KMP in the prevention and treatment of AD. Practical applications Kaempferol (KMP) exerts its ameliorative actions against AD via attenuating oxidative stress and inflammation, reducing Aβ‐induced neurotoxicity, and regulating the cholinergic system. The beneficial effects of KMP were addressed in both in vitro and in vivo studies; however, conducting further research can warrant its long‐term effects as a safe agent. Therefore, after confirming its favorable functions in the prevention and treatment of AD, it could be used as a safe and effective agent.

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Multiple pharmacological activities of Caesalpinia crista against aluminium-induced neurodegeneration in rats: Relevance for Alzheimer’s disease

Cited by 31 publications

References 64 publications

Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus

Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus

Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection

Kaempferol as a potential neuroprotector in Alzheimer's disease

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