Multiple organ toxicity of Datura stramonium seed extracts

Ogunmoyole, Temidayo; Adeyeye, Racheal Imoleayo; Olatilu, Beatrice Oluwatosin; Akande, Olubukola Abidemi; Agunbiade, Oluwadare Joel

doi:10.1016/j.toxrep.2019.09.011

Cited by 26 publications

(21 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Administration of ASEDS resulted in signi cant (p < 0.05) elevation of the antioxidant enzymes activities thereby restoring the normal antioxidant balance, thus, suggesting the ability of ASEDS to boost the rst line of defense against reactive oxygen species (ROS) generated from the bio-activation of cyclophosphamide. The results disagree with the report of Ogunmoyole et al [37] who demonstrated that the activities of SOD, CAT and GP X were depleted by administration of seed extract of D. stramonium L. regardless of the solvent used for the extraction. Cyclophosphamide induction also resulted in signi cant (p < 0.05) decrease in the concentrations of vitamins A, C, and E (Fig.…”

Section: Discussioncontrasting

confidence: 99%

“…It was also observed that HDL-C concentration in each group was signi cantly higher than the corresponding LDL-C concentration indicating the extract possesses athero-protective capacity. The results corroborate the ndings of Ogunmoyole et al [37] who revealed that the HDL-cholesterol and LDL-cholesterol signi cantly increased in serum, liver and heart homogenates after administration of aqueous extract of D. stramonium seeds.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Modulation of Immunological Responses by Aqueous Extract of Datura Stramonium L. Seeds on Cyclophosphamide-Induced Immunosuppression in Wistar Rats

Joshua

Junaidu

Ekpo

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Datura stramonium L. (Solanaceae) is used traditionally in West Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis microbial infections and conjunctivitis. This study investigated the immunomodulatory effects of aqueous seed extract of D. stramonium L. (ASEDS) on Wistar rats.Methods: Following phytochemical analysis of ASEDS and acute toxicity study, thirty Wistar rats of both sexes (180-200 g) were randomized into 6 groups (n = 5). Rats in groups 1, 2 and 3 served as normal, negative and standard controls respectively. Immunosuppression was induced using Cyclophosphamide, 10 mg/kg body weight (b.w.) orally for 27 days. Group 2 rats were untreated while Groups 3-6 rats received 5 mg/kg b.w. Levamisole, 60, 90 and 120 mg/kg b.w. ASEDS orally for 28 days respectively. The effects of ASEDS on immune cells, immunoglobulins A, G and M levels, lipoproteins, and antioxidant status of immunosuppressed rats were evaluated.Results: ASEDS indicated LD50 above 5000 mg/kg b.w. with moderate contents of carbohydrates, glycosides, saponins, tannins, terpenoids, and high contents of alkaloids, flavonoids and phenols. Cyclophosphamide triggered significant (p < 0.05) reduction in total leucocyte count and differentials, IgA, IgG, high-density lipoproteins (HDL), catalase, superoxide dismutase, glutathione peroxidase, vitamins A, C and E levels of the negative control rats. Treatment with ASEDS led to significant (p < 0.05) increases in immune cell counts, immunoglobulin synthesis, HDL levels, and antioxidant status of the test groups.Conclusions: The findings demonstrate the immunomodulatory benefits of ASEDS and its potential in the development of potent immunomodulatory drugs.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 91%

Modulation of Immunological Responses by Aqueous Extract of Datura Stramonium L. Seeds on Cyclophosphamide-Induced Immunosuppression in Wistar Rats

Joshua

Junaidu

Ekpo

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Some of these foreign compounds may cause injury to the liver resulting in the induction and release of liver enzymes and proteins in magnitude higher than the basal level [ 31 ]. Thus, significant alterations (particularly increase) in the levels and activities of serum liver function enzymes (ALT, AST, and ALP), particularly ALT, are indicative of injury on hepatocytes [ 31 ]. Serum proteins such as albumin are synthesized by the liver and the relative level could provide information on the synthetic capability of the liver.…”

Section: Discussionmentioning

confidence: 99%

Toxicological study of aqueous-methanol solvent fraction of methanol extract of Dacryodes edulis leaves

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, D. fastuosa was rendered safe up to a 2000 mg/kg body-weight dosage since it produced no sign of toxicity or mortality. Histological studies demonstrated the reduced weight of the organs, necrotic modifications in the liver accompanied by elevation of serum alkaline phosphatase, serum glutamic-oxaloacetic transaminase, and glutamyl pyruvic transaminase [65,66]. Moreover, due to its toxicity, D. stramonium should not be used in case of glaucoma, pyloric stenosis, paralytic ileus, tachycardia arrhythmias, enlarged prostate, and acute pulmonary edema [8].…”

Section: Toxicology Of Daturamentioning

confidence: 99%

Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review

et al. 2021

View full text Add to dashboard Cite

Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. With these pharmacological activities, D. stramonium is potentially used to treat numerous human diseases, including ulcers, inflammation, wounds, rheumatism, gout, bruises and swellings, sciatica, fever, toothache, asthma, and bronchitis. The primary phytochemicals investigation on plant extract of Datura showed alkaloids, carbohydrates, cardiac glycosides, tannins, flavonoids, amino acids, and phenolic compounds. It also contains toxic tropane alkaloids, including atropine, scopolamine, and hyoscamine. Although some studies on D. stramonium have reported potential pharmacological effects, information about the toxicity remains almost uncertain. Moreover, the frequent abuse of D. stramonium for recreational purposes has led to toxic syndromes. Therefore, it becomes necessary to be aware of the toxic aspects and the potential risks accompanying its use. The present review aims to summarize the phytochemical composition and pharmacological and toxicological aspects of the plant Datura.

show abstract

Multiple organ toxicity of Datura stramonium seed extracts

Cited by 26 publications

References 39 publications

Modulation of Immunological Responses by Aqueous Extract of Datura Stramonium L. Seeds on Cyclophosphamide-Induced Immunosuppression in Wistar Rats

Modulation of Immunological Responses by Aqueous Extract of Datura Stramonium L. Seeds on Cyclophosphamide-Induced Immunosuppression in Wistar Rats

Toxicological study of aqueous-methanol solvent fraction of methanol extract of Dacryodes edulis leaves

Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review

Contact Info

Product

Resources

About