Multiple Organ Dysfunction After Cardiosurgical Interventions

Барбараш, Л. С.; Grigoryev, Evgeny; Плотников, Г. П.; L, Hayes B.; Moiseyenkov, G. V.; Шукевич, Д. Л.; Ivanov, S; Odarenko, Yu. N.

doi:10.15360/1813-9779-2010-5-31

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…Coronary artery bypass grafting (CABG) is considered the most effective and long-lasting method of CHD treatment due to positive postponed results [ 2 ]. However, during surgical intervention, patients are subjected to additional risk, which is caused by the surgery itself as well as pathophysiological changes in homeostasis, caused by the action of anesthetics and cardiopulmonary bypass [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of low-opioid anesthesia in cardiac surgery on dynamics of pro-inflammatory interleukin-6

Loskutov¹,

Maruniak²,

Dryzhyna

et al. 2020

kitp

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Introduction With coronary artery bypass grafting, patients are subjected to additional risk caused by both surgical treatment itself and pathophysiological changes in homeostasis, provoked by the action of anesthetics and cardiopulmonary bypass. Material and methods The study involved 60 patients, who had been subjected to coronary artery bypass grafting with cardiopulmonary bypass. All patients were divided into two groups: group I (30 patients) – low-opioid scheme of anesthesia and group II (30 patients) – standard scheme of anesthetic management. Blood interleukin-6 (IL-6) was identified before and after cardiopulmonary bypass using an ELISA test. Results Having compared IL-6 values between study groups after completion of cardiopulmonary bypass, it was established that IL-6 levels were 27.51% ( p = 0.001) lower in patients of group I compared with the results of patients in group II. Patients in the first group had a significantly shorter time of mechanical ventilation compared to group II (2.1 ±0.7 hours vs. 3.9 ±0.9 hours, p = 0.021). Low cardiac output syndrome was significantly less frequently reported in patients of group I (10.0% vs. 33.3%, p = 0.028). In addition, patients in group I had a significantly shorter time of intensive care unit (ICU) stay (2.5 ±0.7 days vs. 3.5 ±1.0 days, p = 0.044). Conclusions Application of multimodal low-opioid anesthesia was associated with significantly lower IL-6 at the end of surgery, shorter mechanical ventilation duration, less frequent low cardiac output syndrome and need for catecholamines, and shorter ICU stays.

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Section: Introductionmentioning

confidence: 99%

Influence of low-opioid anesthesia in cardiac surgery on dynamics of pro-inflammatory interleukin-6

Loskutov¹,

Maruniak²,

Dryzhyna

et al. 2020

kitp

View full text Add to dashboard Cite

show abstract

“…MODS is defined as the presence of cumulative dysfunction of several organs (three and more). This complication requires critical care and remains the main cause of death among patients in the in-hospital period [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…accompanied by alterations of microcirculation, contribute to the development of systemic alterations [3]. Despite the fact that SIRS is commonly regarded as a physiological mechanism of adaptation to surgical trauma and reperfusion injury in the early postoperative period, some patients experience its pathological and uncontrollable progress, resulting in MODS and subsequent death [2]. Immune reactions are the main pathogenetic links of SIRS and its onset represents the result of both cellular and humoral immunity dysfunction [4].…”

Section: Introductionmentioning

confidence: 99%

Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and polymorphic variants of TREM-1 in the development of multiple organ dysfunction syndrome after coronary artery bypass grafting

Хуторная¹,

Понасенко²,

Цепокина³

et al. 2019

Obŝaâ reanimatologiâ

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The onset of critical complications (multiple organ dysfunction syndrome, MODS) after coronary artery bypass grafting is the result of severe stress response. The key etiopathological factor of the induction phase of the complex pathological process, which ultimately leads to dysfunction of organs and systems, is the dysfunction of the immune response. The characteristics of reactions of the immune system in a particular individual are genetically determined and realized through innate immunity activation. Aim. To determine the role of TREM-1 gene polymorphism through the changes of sTREM serum levels and their contribution to the development of multiple organ dysfunction syndrome after coronary artery bypass grafting.Materials and Methods. 132 patients with coronary atherosclerosis who had undergone coronary artery bypass grafting were included in the study. Of them, 30 patients had multiple organ dysfunction syndrome in the early postoperative period. sTREM serum levels were measured using enzyme immunoassay. Genotyping of polymorphic loci of the TREM-1 gene was performed with real-time allele-speciﬁc PCR using TaqMan system.Results. Signiﬁcant diﬀerences in sTREM levels among patients with and without MODS were found. sTREM levels depend on the carriage of certain allelic variants in the three polymorphic loci of the TREM-1 gene (rs1817537, rs2234246, rs3804277)Conclusion. The relationships of the levels of the circulating soluble form of TREM-1 and the polymorphic variants of the coding TREM-1 gene with the severity of MODS were determined in coronary artery disease patients after coronary artery bypass grafting.

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Mitochondrial dna as a possible marker of multiple organ failure in cardiac patients

Понасенко¹,

Цепокина²,

Ивкин³

et al. 2021

Anaes. i reanim.

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Multiple Organ Dysfunction After Cardiosurgical Interventions

Cited by 6 publications

References 7 publications

Influence of low-opioid anesthesia in cardiac surgery on dynamics of pro-inflammatory interleukin-6

Influence of low-opioid anesthesia in cardiac surgery on dynamics of pro-inflammatory interleukin-6

Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and polymorphic variants of TREM-1 in the development of multiple organ dysfunction syndrome after coronary artery bypass grafting

Mitochondrial dna as a possible marker of multiple organ failure in cardiac patients

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