Multiple oral papules in a native South American girl. Focal epithelial hyperplasia (Heck's disease)

Jaramillo, Felipe; Rodriguez, Garcia

doi:10.1001/archderm.127.6.888

Cited by 8 publications

(9 citation statements)

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“…The individual lesions are discrete and soft, ranging in size from 1 to 5 mm in diameter. The morphologic differential diagnosis includes biting papitloma, condyloma acuminatum, diffuse epithelial hyperplasia (in tobacco chewers), mucosal neuroma, oral florid papillomatosis, vemicae vulgaris, and white sponge nevus (12). As in our patient, the condition may be misinterpreted to represent sexual abuse and the family may subsequently be subjected to investigation by childhood protective social services.…”

Section: Discussionmentioning

confidence: 77%

“…A high frequency of FEH has been observed among Indians from North, Central, and South America (9,10,12,13), Eskimos from Greetiland and North Canada (14)(15)(16), and people in South Africa (17,18). This condition has also been reported, although less commonly, in individuals from Argentina (19), Australia (20), Denmark (14), East Africa (Sudan) (21), Egypt (22), England (7), Finland (8,23), Scotland (7), Iran (1), Iraq (24), Israel (25), Italy (26), Lybia (27), Mexico (28)(29)(30), the Netherlands (31), North Africa (11), Norway (2,32), Puerto Rico (33), Sweden (34,35), Turkey (II), and West Africa (Nigeria) (36).…”

Section: Discussionmentioning

confidence: 99%

“…Occasional koilocytes, mitosoid cells (cells demonstrating a mitosis-like nuclear degeneration), and/or cells with ballooning degeneration (intracellular edema) and distorted nuclei-all indicative of viral cytopathic changes-may also be present (27,40). Binucleated epithelial cells in the middle layers of the epithelium may be noted (12).…”

Section: Discussionmentioning

confidence: 99%

“…Sections of tissue previously shown to contain HPV DNA were used as positive tissue controls. The biotin-labeled probes were prepared using a commercially available kit (BioNick Labeling System, BRL Life Technologies, Gaithersburg, MD) and the in situ hybridization reactions were performed as (12), is also seen in the epithelium, (Hematoxylin & eosin; magnification 25x,) described previously (4). Although the patient's oral lesions had the clinical and histologic features of FEH, we were unable to detect HPV6, 11, 13, or 32 in the paraffin-embedded tissue.…”

Section: Case Reportsmentioning

confidence: 99%

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Focal Epithelial Hyperplasia: Heck Disease

Cohen¹,

Hebert²,

Adler‐Storthz³

1993

Pediatric Dermatology

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Two sisters of Mexican ancestry had focal epithelial hyperplasia (FEH). The lesions on the oral mucosa of the older child were initially misinterpreted as representing sexual abuse. Microscopic evaluation of a hematoxylin and eosin-stained section from a lower lip papule demonstrated the histologic features of FEH. Although human papillomavirus (HPV) type 13 and HPV32 have been most consistently present in FEH lesions, types 6, 11, 13, and 32 were not detected in the paraffin-embedded tissue specimen of our patient using an in situ hybridization technique. The lesions persisted or recurred during management using destructive modalities; subsequently, they completely resolved spontaneously.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Case Reportsmentioning

confidence: 99%

See 2 more Smart Citations

Focal Epithelial Hyperplasia: Heck Disease

Cohen¹,

Hebert²,

Adler‐Storthz³

1993

Pediatric Dermatology

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“…The long-term behaviour of FEH lesions is unclear, in particular if recurrence is likely. FEH lesions may progress and increase in size, remain unchanged and persist for several years or may undergo spontaneous regression and resolution within months to years (5,8,11,12,21,24,25,63,71). FEH lesions may show a wide variation in duration.…”

Section: Long-term Behaviourmentioning

confidence: 99%

Focal epithelial hyperplasia – an update

Said

Leão

Fedele

et al. 2012

J Oral Pathology Medicine

114

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Focal epithelial hyperplasia (FEH) is an asymptomatic benign mucosal disease, which is mostly observed in specific groups in certain geographical regions. FEH is usually a disease of childhood and adolescence and is generally associated with people who live in poverty and of low socioeconomic status. Clinically, FEH is typically characterized by multiple, painless, soft, sessile papules, plaques or nodules, which may coalesce to give rise to larger lesions. Human papillomavirus (HPV), especially genotypes 13 and 32, have been associated and detected in the majority of FEH lesions. The clinical examination and social history often allow diagnosis, but histopathological examination of lesional tissue is usually required to confirm the exact diagnosis. FEH sometimes resolves spontaneously however, treatment is often indicated as a consequence of aesthetic effects or any interference with occlusion. There remains no specific therapy for FEH, although surgical removal, laser excision or possibly topical antiviral agents may be of benefit. There remains no evidence that FEH is potentially malignant.

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Oral Manifestations of Viral Diseases

Lynch

Mucosal Immunology and Virology

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Multiple oral papules in a native South American girl. Focal epithelial hyperplasia (Heck's disease)

Cited by 8 publications

References 0 publications

Focal Epithelial Hyperplasia: Heck Disease

Focal Epithelial Hyperplasia: Heck Disease

Focal epithelial hyperplasia – an update

Oral Manifestations of Viral Diseases

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