Multiple Nonfamilial Unilateral Trichoepitheliomas: Report of a Case—Mini Review of the Literature

Mandekou‐Lefaki, Ioanna; Theodosiou, Grigorios; Delli, Florentina; Oikonomou, Dimitrios; Papageorgiou, Marina

doi:10.1155/2019/6821854

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…24 Conversely, two articles reported no adverse effects. 13,25 Treatment with imiquimod cream was associated with either no adverse effects 26 or local skin irritation, 15 mild local skin reactions (itching, erythema, scaling), moderate local skin reactions (intense erythema, crusting, vesicles, erosion) and systemic reactions (nausea, headache, flu-like symptoms). 23 Combination therapy with imiquimod cream and tretinoin gel caused local skin irritation and inflammatory acne in one patient.…”

Section: Resultsmentioning

confidence: 99%

“…15,30 The use of topical imiquimod for the treatment of trichoepithelioma has been reported by several studies. 15,16,23,26 Mandekou-Lefaki et al reported a case of multiple nonfamilial facial trichoepithelioma treated with topical Management of multiple trichoepithelioma e197 imiquimod 5% cream three times per week. 26 After three months of treatment, less than 25% of the lesions observed at the baseline examination were still present, and a size reduction of 1-2 mm was seen in residual lesions, representing a partial response to therapy.…”

Section: Sirolimus (Also Known As Rapamycin)mentioning

confidence: 99%

“…15,16,23,26 Mandekou-Lefaki et al reported a case of multiple nonfamilial facial trichoepithelioma treated with topical Management of multiple trichoepithelioma e197 imiquimod 5% cream three times per week. 26 After three months of treatment, less than 25% of the lesions observed at the baseline examination were still present, and a size reduction of 1-2 mm was seen in residual lesions, representing a partial response to therapy. This finding was supported by Alessi et al in a retrospective study analysing the use of imiquimod 5% cream to treat 123 cutaneous tumours of several types.…”

Section: Sirolimus (Also Known As Rapamycin)mentioning

confidence: 99%

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Management of multiple trichoepithelioma: A review of pharmacological therapies

2021

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Trichoepithelioma is a rare benign adnexal neoplasm that can occur in various forms including solitary, multiple, familial or nonfamilial. Multiple facial trichoepithelioma can be associated with significant psychosocial burden. Conventional treatment modalities such as surgical excision and ablative laser have variable results and can be associated with unacceptable complications and tumour regrowth. Pharmacological interventions such as topical and systemic agents are potentially effective but clinical data are limited and treatments are poorly standardised. We review the available evidence to determine the role of pharmacological therapies in the management of multiple trichoepithelioma. Demographic and clinical data were retrospectively collected from the available English literature. Majority of cases treated with pharmacological therapies (93.75%) had a positive treatment outcome, achieving partial lesion response. Adverse effects associated with pharmacological therapies were generally well tolerated and did not interrupt treatment. There are limitations as to how our results can be interpreted owing to the paucity of good quality evidence, spectrum of disease severity, and diversity of study designs utilised in the included articles. Nonetheless, the results of our study indicate that while most pharmacological interventions for multiple trichoepithelioma produce a partial response, they can be employed as effective suppressive therapies, either alone or in conjunction with conventional treatments. The current evidence for pharmacological therapies remains largely anecdotal justifying the need for further clinical studies in this area.

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Section: Resultsmentioning

confidence: 99%

Section: Sirolimus (Also Known As Rapamycin)mentioning

confidence: 99%

Section: Sirolimus (Also Known As Rapamycin)mentioning

confidence: 99%

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Management of multiple trichoepithelioma: A review of pharmacological therapies

2021

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“…A case of unilateral multiple non-familial trichoepithelioma since the age of 5 years has also been reported in a 34y/F (12). A case of MTE without family history has been reported in a 9 year old child who presented with asymptomatic papules since the age of 5 months (13).…”

Section: Case Reportmentioning

confidence: 95%

Multiple Trichoepithelioma

Babbita¹,

Sharada²,

Narasimhalu³

et al. 2020

Biomedicine

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Multiple non-familial Trichoepithelioma is a rare benign adnexal tumour that originates from pilosebaceous follicle. The incidence is predominantly at puberty or early part of childhood. The common sites of occurance of trichoepithelioma are upper lip, forehead, scalp and nose. Trichoepithelioma in young women may lead to cosmetic disfigurement. We report a case of multiple non-familial trichoepithelioma who presented with complaints of multiple skin coloured raised lesions on her face since the age of 15 years. Keywords: Benign adnexal tumour; horn cyst; multiple non-familial trichoepithelioma.

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“…Eyebrows, cheeks, and eyelids are often involved [ 1 – 3 ]. Onset is usually seen in the childhood as asymptomatic, translucent, firm, papulo-nodular lesions predominantly affecting naso-labial folds and the central part of the face [ 6 , 7 ]. Lesions are often roughly symmetrical in shape and distribution and increase in size and number with age, producing a significant cosmetic disfigurement.…”

Section: Introductionmentioning

confidence: 99%

Clinical, Histopathological, and Management Challenges of Multiple Familial Trichoepithelioma: A Case Report of a Patient Presenting with Multiple Facial Papules

Dissanayaka

Dassanayaka²,

Jayasooriya

2020

Case Reports in Dentistry

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Trichoepitheliomas (TE) are benign skin tumours of the pilosebaceous apocrine unit with follicular differentiation. Multiple familial trichoepithelioma (MFT) is a considerably rare condition inherited in an autosomal dominant pattern. We present a case of a 15-year-old male who presented with multiple papulo-nodular lesions in the central face and a family history of a similar type of lesions from his mother. Significance of consideration of various clinical differential diagnoses with serious pathological outcomes, strategies followed in the diagnosis including histopathological evaluation aided by immunohistochemical investigations, and subsequent challenges that may be faced in the management of MFT in light of the presentation with multiple facial papules are documented in this case report.

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Multiple Nonfamilial Unilateral Trichoepitheliomas: Report of a Case—Mini Review of the Literature

Cited by 7 publications

References 22 publications

Management of multiple trichoepithelioma: A review of pharmacological therapies

Management of multiple trichoepithelioma: A review of pharmacological therapies

Multiple Trichoepithelioma

Clinical, Histopathological, and Management Challenges of Multiple Familial Trichoepithelioma: A Case Report of a Patient Presenting with Multiple Facial Papules

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