1972
DOI: 10.1136/ard.31.5.421-a
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Multiple nodules in juvenile chronic polyarthritis.

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Cited by 8 publications
(7 citation statements)
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“…We were unable to obtain data from these patients' charts to support this hypothesis. Unlike in earlier studies (2, 3, 6, 9), no patients with JRA in the present study died of amyloidosis, late development of other autoimmune disease, or suicide (9, 10). Two patients with systemic JRA died of macrophage activation syndrome, which is probably currently the most common cause of death in patients with systemic JRA (12).…”
Section: Discussioncontrasting
confidence: 94%
See 1 more Smart Citation
“…We were unable to obtain data from these patients' charts to support this hypothesis. Unlike in earlier studies (2, 3, 6, 9), no patients with JRA in the present study died of amyloidosis, late development of other autoimmune disease, or suicide (9, 10). Two patients with systemic JRA died of macrophage activation syndrome, which is probably currently the most common cause of death in patients with systemic JRA (12).…”
Section: Discussioncontrasting
confidence: 94%
“…While we tend to study pediatric rheumatology outcomes in terms of remission versus active disease, organ and radiologic damage, function, and quality of life, there is a small but significant increase in mortality rates among these patients. An increased rate of mortality has been found in juvenile rheumatoid arthritis (JRA) (2–12), childhood systemic lupus erythematosus (SLE) (13–21), dermatomyositis (DM) (22–25), various vasculitides (26–30), and systemic sclerosis (SSc) (31–33).…”
mentioning
confidence: 99%
“…T lymphocytes and plasma cells are the predominant cells in situ in the inflammatory synovial membrane in both RA and JRA (5,(18)(19)(20)(21)(22)(23). According to our findings, recent-onset JRA differs from chronic JRA both in the intensity of the mononuclear cell infiltration and in the composition of the infiltrates.…”
Section: Discussionsupporting
confidence: 54%
“…In adult RA, rheumatoid nodules are classically detected in patients with severe active disease and are associated with other extraarticular manifestations (1). In JRA, rheumatoid nodules are rarely observed and are usually restricted to patients with polyarticular-onset, RF-positive disease without other extraarticular findings (2). It is well known that SAARDs may accelerate the appearance and pro- gression of nodules in RA patients, and MTX is the SAARD most frequently associated with nodule progression (10)(11)(12)(13).…”
Section: Discussionmentioning
confidence: 99%
“…In juvenile rheumatoid arthritis (JRA), rheumatoid nodules seldom occur (5-10% of cases) and are usually confined to the subset of patients with polyarticular, rheumatoid factor (RF)-positive disease. In children, as in adults, this extraarticular manifestation is associated with a poor outcome (2).…”
Section: Methotrexate-associated Appearance and Rapid Progression Of mentioning
confidence: 99%