Multiple neutrophilic dermatoses in myelodysplastic syndrome

García, Julio V. González; Sánchez, M.A Cueva; Fonseca, Eduardo

doi:10.1046/j.1365-2230.2001.00844.x

Cited by 36 publications

(22 citation statements)

References 11 publications

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“…These patients can be diagnosed as having a ''neutrophilic dermatosis.'' Such overlap conditions have been reported in patients with myeloid disorders, 3,15 IgA monoclonal gammopathy, 16 inflammatory colitis, 17 and rheumatoid arthritis. 18 It is important for dermatologists to recognize such complex clinical conditions, even in the absence of associated systemic diseases.…”

Section: Deep Neutrophilic Dermatosesmentioning

confidence: 66%

From acute febrile neutrophilic dermatosis to neutrophilic disease: Forty years of clinical research

Wallach

Vignon‐Pennamen

2006

Journal of the American Academy of Dermatology

196

122

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Section: Deep Neutrophilic Dermatosesmentioning

confidence: 66%

From acute febrile neutrophilic dermatosis to neutrophilic disease: Forty years of clinical research

Wallach

Vignon‐Pennamen

2006

Journal of the American Academy of Dermatology

196

122

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“…7 Our patient demonstrated multiple unusual clinical features. Approximately 20% of patients with Sweet's syndrome have an associated malignancy which, in more than 85% of cases, is a hematologic disorder, most commonly acute myelogenous leukemia.…”

Section: Discussionmentioning

confidence: 64%

A case of recurrent Sweet’s syndrome in an 80‐year‐old man: a clue to an underlying malignancy

et al. 2006

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An 80-year-old man presented with multiple erythematous papules on the trunk and extremities of a few weeks' duration. He had no past medical or family history of skin diseases or any other medical diseases. A biopsy showed a perivascular lymphohistiocytic infiltrate and sparse neutrophils with several atypical lymphocytes in the deeper dermis. With an initial diagnosis of T-cell pseudolymphoma or unspecified neutrophilic dermatosis, he showed a brisk response to an intramuscular injection of triamcinolone acetonide (40 mg/mL). After 1 month, his skin lesion recurred. Steroid was given with a good clinical response. One month later, however, his skin lesion relapsed. At this time, he presented with disseminated pustulopapular lesions on the trunk and extremities. Examination revealed multiple, variable-sized, erythematous plaques with central pustules on the extremities (Fig. 1). The mucous membranes were not involved. He had no pain or tenderness. He had no systemic symptoms. Laboratory tests showed a hemoglobin level of 10.3 g/dL, a leukocyte level of 6,900/mm(3), with an increased proportion of segmented nuclear neutrophils (83%), and an elevated C-reactive protein. A skin biopsy revealed a dense perivascular and interstitial infiltrate composed of neutrophils with marked dermal edema (Fig. 2). Sweet's syndrome was the final diagnosis and he was treated with oral prednisolone (30-40 mg/day) and dapsone (50 mg/day) for 2 months. As this 80-year-old patient had a recurrent history of similar skin lesions and anemia, an underlying hematologic malignancy was suspected. A bone marrow biopsy showed typical myelodysplastic syndrome (MDS). The hemoglobin level was decreased to 5.3 g/dL during a follow-up period of 5 months. The skin lesions recurred despite oral steroids and dapsone. The patient received only symptomatic treatment, such as a transfusion, for the underlying malignancy MDS.

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“…Refractory anemia is the most low‐risk subtype of MDS. There are some individual case reports in the published work that SS can be associated with MDS 26–34 …”

Section: Discussionmentioning

confidence: 99%

Sweet's syndrome associated with skin methicillin‐resistant Staphylococcus epidermidis infection

Xiao

Gao

et al. 2007

The Journal of Dermatology

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A 53-year-old Chinese man presented with fever, a painful exudative plaque around his left eye and subsequent multiple tender plaques and nodules on his bilateral face, neck and back. He had a 12-year history of refractory anemia, a subtype of myelodysplastic syndrome. Repeated bacterial cultures of exudates from the lesion of the left zygomatic area showed growth of methicillin-resistant Staphylococcus epidermidis. A biopsy of a plaque on the back showed edema of the papillary dermis and marked neutrophilic infiltrates in the upper dermis. The patient was diagnosed with Sweet's syndrome (SS), and responded well to combination therapy of amoxycilline/sulbactam and corticosteroids. To our knowledge, this is the first reported case of SS associated with skin S. epidermidis infection.

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Multiple neutrophilic dermatoses in myelodysplastic syndrome

Cited by 36 publications

References 11 publications

From acute febrile neutrophilic dermatosis to neutrophilic disease: Forty years of clinical research

From acute febrile neutrophilic dermatosis to neutrophilic disease: Forty years of clinical research

A case of recurrent Sweet’s syndrome in an 80‐year‐old man: a clue to an underlying malignancy

Sweet's syndrome associated with skin methicillin‐resistant Staphylococcus epidermidis infection

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