Multiple myeloma

Abstract

Advances in the imaging and treatment of multiple myeloma have occurred over the past decade. This article summarises the current status and highlights how an understanding of both is necessary for optimum management.

Appearance of monoclonal plasma cell diseases in whole‐body magnetic resonance imaging and correlation with parameters of disease activity

“…[3][4][5][6] In the aforementioned monoclonal plasma cell disorders, the bone marrow involvement may be present in different patterns: diffuse bone marrow infiltration and focal lesions. Diffuse bone marrow infiltration is characterized by malignant plasma cells, mixed up with normal bone marrow cells, still preserving the cancellous bone structure.…”

“…1,2 Although MGUS, being the most common disorder of plasma cells and occurring in 2% of persons older than 50 years, has an overall annual risk of progression of only 1% per year, the rate of transformation of SMM to MM or systemic amyloidosis (AL) has been shown to be 10% per year in the first 5 years. [3][4][5][6] In the aforementioned monoclonal plasma cell disorders, the bone marrow involvement may be present in different patterns: diffuse bone marrow infiltration and focal lesions. Diffuse bone marrow infiltration is characterized by malignant plasma cells, mixed up with normal bone marrow cells, still preserving the cancellous bone structure.…”

Various presentations of multiple myeloma MRI review: A Case series

“…[6] Our studies too show three cases within this range; only one (case no.2) is of 35 years old. It has a male predilection (M: F 2:1).…”

“…Sagittal studies of the spine enable screening of a high proportion of hematopoietic marrow and detection of any potential threat to the spinal cord as depicted in our study. [6] Extraosseous multiple myeloma usually occurs as an extension from intraosseous (as seen in our cases 2,3,4) or less frequently arises from within the soft tissue. Zones of high signal on T2WI peripheral to the Gd-contrast enhancement portion of the lesion may represent zones of tumor invasion or peripheral oedema.…”

Ekstraaksiyel Beyin Tumorleri

“…Diffüz veya multifokal olabilir. Plazmositom fokal soliter formudur [207,208]. Dördüncü ve sekizinci dekadlar arasında en sık görülen primer malign kemik tümö-rüdür.…”