Multiple myeloma with intracranial extension and bilateral renal infiltration: A case report and review of the literature

Zhang, Min-Juan; Su, Guohong; Shen, Jie; Liu, Feng‐Hai; Xu, Yanfeng; Xiao-ling, Zhang; Wang, Qing; Wang, Ruihuan; Liu, Chunyan; Zhao, Yu-Lei

doi:10.3892/ol.2015.3567

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…It is generally believed that EMP may be occult MM. The diagnosis of EMPs is problematic because it requires confirmation by extensive radiology, hematology, and histopathology ( 6 – 8 ). At present, the diagnostic criteria for EMP have not been unified, but the principal bases are I primary extramedullary plasmacytoma confirmed by pathology; II bone marrow plasma cell infiltration occupying less than 5% of nuclear cells; III normal skeletal imaging examination with no lytic changes; IV anemia, hypercalcemia and renal insufficiency caused by no plasmacytosis; V no M protein in serum or a small amount of M protein detected ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Plasmacytoma of External Urethral Meatus

Zeng

Zhao

et al. 2022

Front. Endocrinol.

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RationaleExtramedullary plasmacytoma (EMP) can occur in various parts of the body. It is generally accepted that the highest site of occurrence is the head and neck region (80% to 90%), followed by the gastrointestinal tract and the skin. It is worth mentioning that the site of disease, in this case, was the urethral meatus, which is extremely rare in clinical practice.Patient ConcernsA 50-year-old female complained of an episode of painless gross hematuria without symptoms of frequent urination, urgency, abdominal pain, abdominal distension, fever, or oliguria. The patient has no history of smoking or drinking and denied any family history of solid malignancy or hematological disease.Diagnosis and InterventionsUrethrocystoscopy revealed urethral polypoid hyperplasia, which we initially thought could be a urethral caruncle. The patient was asked to undergo caruncle resection after 1 week of potassium permanganate sitz bath, and postoperative pathology revealed plasmacytoma. After that, a whole-body MRI showed no other lesions. She received postoperative radiotherapy.OutcomesDuring radiotherapy, the patient’s condition and appetite were fair, and the skin mucositis was I°. Pelvic contrast-enhanced MRI and whole-body PET-CT 6 months after urethral meatus lumpectomy and radiotherapy showed changes without obvious abnormal signs. No recurrence or metastasis was detected after one year of follow-up.LessonsUrinary EMP is a rare disease. It is not easy to diagnose due to its rare site of occurrence and non-specific symptoms. The diagnosis of EMP requires a combination of imaging studies and pathological findings. Currently, surgery combined with radiotherapy or radiotherapy alone is the mainstay treatment and usually results in an acceptable local control rate. At the same time, chemotherapy cannot be ignored.

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Section: Discussionmentioning

confidence: 99%

Case Report: Plasmacytoma of External Urethral Meatus

Zeng

Zhao

et al. 2022

Front. Endocrinol.

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“…The majority of CNS cases are found in relapsed disease; however, most of these cases typically present as a leptomeningeal rather than an intraparenchymal process. Several cases of solitary intracranial plasmacytoma have been reported, but these are typically intraosseous tumors [ 3 , 8 , 9 , 10 ]. Extraosseous intracranial plasmacytoma is rarely seen with relapsed disease.…”

Section: Discussionmentioning

confidence: 99%

Relapsed Multiple Myeloma Presenting as Intracranial Plasmacytoma and Malignant Pericardial Effusion following Recent Allogeneic Stem Cell Transplantation

et al. 2017

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Although rare, both central nervous system and pericardial involvement of myeloma have been well described in the literature. Their simultaneous occurrence in relapsed disease, however, has not been previously reported. This case describes a 54-year-old female who was treated for high-risk multiple myeloma with multiregimen chemotherapy and allogeneic hematopoietic stem cell transplantation. Four months after transplant, she was found to have relapsed disease manifesting as an extraosseous, intracranial plasmacytoma and simultaneous malignant pericardial effusion. Her disease characteristics, treatment course, radiologic and pathologic findings are described in detail, and we review the previous literature to determine the various aspects of her disease that may have contributed to her aggressive clinical course.

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“…[4,14,25] Accounting for <5% of all plasma cell neoplasms, solitary plasmacytoma is classified into intraosseous or extraosseous occurrence. [1,4,8,17,[28][29][30]33] Extraosseous solitary plasmacytoma is far less common and primary intracranial solitary plasmacytoma (PISP) is exceedingly rare. [4,10,12,21,26,29,32] Although intracranial hemorrhage from plasmacytoma has been reported sporadically in the setting of multiple myeloma, [3,5,13,15,18,26] there has been no report of spontaneous intraparenchymal hemorrhage from PISP.…”

Section: Introductionmentioning

confidence: 99%

Novel case of primary intracranial solitary plasmacytoma presenting with significant intratumoral hemorrhage

Sato

Takayanagi

Takami

et al. 2022

Surgical Neurology International

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Background: Solitary plasmacytoma is a localized lesion comprising monoclonal neoplastic proliferation of plasma cells. This disease is rarely encountered and few reports have described primary intracranial solitary plasmacytoma (PISP). Case Description: We report a case of PISP that presented initially as status epilepticus and exhibited massive intratumoral hemorrhage at the subcortical area. To the best of our knowledge, this is the first recorded presentation of this pathology in this manner. Following evacuation of the hematoma and decompressive craniectomy, the patient underwent radiation therapy and showed no sign of tumor recurrence at 3 years after diagnosis. Conclusion: This case reveals that PISP can present as subcortical intraparenchymal hemorrhage. It should be emphasized that the precise diagnosis of this disease is of utmost importance, because solitary plasmacytoma without a background of multiple myeloma responds well to radiation therapy.

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Multiple myeloma with intracranial extension and bilateral renal infiltration: A case report and review of the literature

Cited by 4 publications

References 23 publications

Case Report: Plasmacytoma of External Urethral Meatus

Case Report: Plasmacytoma of External Urethral Meatus

Relapsed Multiple Myeloma Presenting as Intracranial Plasmacytoma and Malignant Pericardial Effusion following Recent Allogeneic Stem Cell Transplantation

Novel case of primary intracranial solitary plasmacytoma presenting with significant intratumoral hemorrhage

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