Multiple myeloma presenting with chronic diarrhea: A case

Zhang, Meng-Qiao; Liu, Kui-Liang; Wang, Ya-Dan; Su, Hui; Wu, Jing; Liu, Hong

doi:10.11569/wcjd.v24.i32.4415

Cited by 2 publications

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“…Another possible explanation for this is that it may be related to the utilization of chemotherapeutic and immunosuppressive agents that can cause diarrhea, nausea, vomiting and gastrointestinal reactions. In addition, myeloma cell in ltration associated with digestive system amyloidosis and coagulation disorders are able to set off gastrointestinal symptoms [23]. The average age of the participants in this study was 57.9 years.…”

Section: Discussionmentioning

confidence: 90%

Title: Risk factors for non-infectious diarrhea of patients with multiple myeloma after chimeric antigen receptor T-cell immunotherapy: A retrospective observational study

Ding

Chen

Huang

et al. 2023

Preprint

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Purpose To ascertain the risk factors and prevalence of non-infectious diarrhea among participants with multiple myeloma who treated with chimeric antigen receptor T-cell immunotherapy. Methods This study enrolled 88 patients with multiple myeloma who received chimeric antigen receptor T-cell immunotherapy at one tertiary general hospital in China. Participants were categorized into diarrhea subgroup and non-diarrhea subgroup according to the occurrence of diarrhea. Demographic data and self-reported measurements and planning were obtained from questionnaires and clinical data from hospital databases. Results In total, 50 patients suffered from non-infectious diarrhea, with the prevalence of 56.8%. Multiple logistic regression analysis showed that severe cytokine release syndrome (OR = 5.980), underlying diseases (OR = 4.184), previous treatment lines ≥ 6 (OR = 6.292) were prominent hazardous factors for non-infectious diarrhea (p < 0.05). Conclusion The incidence rate of non-infectious diarrhea in patients with multiple myeloma after CAR-T therapy was at a high level. Severe cytokine release syndrome, previous treatment lines ≥ 6 and the underlying diseases were important predictors for non-infectious diarrhea. Medical staff should early evaluate these major factors to reduce the risk of diarrhea (184 words).

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Section: Discussionmentioning

confidence: 90%

Title: Risk factors for non-infectious diarrhea of patients with multiple myeloma after chimeric antigen receptor T-cell immunotherapy: A retrospective observational study

Ding

Chen

Huang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The average age of the participants in this study was 57.9 years. A study reported that advanced age was one of the most risk factors for diarrhea, the immunity and gastrointestinal absorption function would deteriorate with aging [24]. In view of the above factors, nurses should positively master the theoretical knowledge related to CAR-T therapy and improve the cognition of adverse outcomes of non-infectious diarrhea, especially the early screening and evaluation of risk factors for non-infectious diarrhea.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for non-infectious diarrhea of patients with multiple myeloma after chimeric antigen receptor T- cell immunotherapy: A retrospective observational study

Ding

Chen

Huang

et al. 2023

Preprint

View full text Add to dashboard Cite

Aims Patients with multiple myeloma after chimeric antigen receptor T-cell immunotherapy suffered from diarrhea. Recurrent diarrhea further conversely decreases nutritional status Methods This study enrolled 88 patients with multiple myeloma who received chimeric antigen receptor T-cell immunotherapy at one tertiary general hospital in China. Participants were categorized into diarrhea subgroup and non-diarrhea subgroup according to the occurrence of diarrhea. Demographic data and self-reported measurements and planning were obtained from questionnaires and clinical data from hospital databases. Results In total, 50 patients suffered from non-infectious diarrhea, with the prevalence of 56.8%. Multiple logistic regression analysis showed that severe cytokine release syndrome (OR = 5.980), underlying diseases (OR = 4.184), previous treatment lines ≥ 6 (OR = 6.292) were prominent hazardous factors for non-infectious diarrhea (p < 0.05). Conclusions The incidence rate of non-infectious diarrhea in patients with multiple myeloma after CAR-T therapy was at a high level. Severe cytokine release syndrome, previous treatment lines ≥ 6 and the underlying diseases were important predictors for non-infectious diarrhea. Medical staff should early evaluate these major factors to reduce the risk of diarrhea.

show abstract

Multiple myeloma presenting with chronic diarrhea: A case

Cited by 2 publications

References 0 publications

Title: Risk factors for non-infectious diarrhea of patients with multiple myeloma after chimeric antigen receptor T-cell immunotherapy: A retrospective observational study

Title: Risk factors for non-infectious diarrhea of patients with multiple myeloma after chimeric antigen receptor T-cell immunotherapy: A retrospective observational study

Risk factors for non-infectious diarrhea of patients with multiple myeloma after chimeric antigen receptor T- cell immunotherapy: A retrospective observational study

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