Multiple Myeloma: Lesions of the Extra-osseous Hematopoietic System

Clinico-pathological study of multiple myeloma in Jamaica.

“…It is not suggested that the disease has a more rapid course in the negro, but these findings only reflect the late presentation of patients, the more advanced stage of the disease, and to some extent lack of the more modern therapeutic facilities. Extra-medullary involvement at post mortem was common in the present study, supporting the observations of recent investigators (Lowenhaupt, 1945;Churg and Gordon, 1950;Hayes et al, 1952;Shapiro and Watson, 1953;Snapper et al, 1953, andCarson et al, 1955), who have emphasised the widespread extra-medullary involvement produced by the disease, which earlier was considered to be very uncommon (Geschicter and Copeland, 1928 Jaffe, 1947;Snapper et al, 1953, Carson et al, 1955Innes and Newall, 1961;Griffiths, 1966;Rappaport, 1966) concerning the better prognosis of solitarv plasmocytoma, and the fact that it is closely related to multiple myeloma.…”

IgG Lambda Myeloma Presenting as Plasmacytic Ascites: Case Report and Review of Literature

“…A review of 64 necropsies of patients with multiple myeloma revealed exudative ascites in nine cases, but with no evidence of peritoneal infiltration [8]. No peritoneal involvement was detected in another series of 32 autopsies, while one case was detected in a series of 30 autopsies limited to patients with extraosseous myeloma [9,10].…”

Primary Plasmacytoma of Lymph Nodes

“…In advanced cases infiltration of lymph nodes can be found in up to 40°/o of cases at au topsy [4,21], but this involvement is mostly only microscopical [21], It is a metastatic, near terminal event [21] and seldom gives rise to gross enlargement of peripheral lymph nodes [4].…”