Multiple Myeloma: Clinico-hematological profile in a tertiary care hospital: a three years study

Abstract

Background: To analyze the clinical findings and haematological profile of multiple myeloma patients. Material and methods:All newly diagnosed patients of multiple myeloma between January' 2013 to December' 2015 in the department of pathology, Indira Gandhi Medical College, Shimla were the study subjects. The history and clinical findings were recorded. All relevant blood, radiological investigations including peripheral smears, bone marrow aspiration and biopsy were done.Results: Fifty one patients were diagnosed with multiple myeloma and they comprised 19% of all haematological malignancies. Out of these, 30 were males and 21 females with a mean age of presentation 58.38 years. The commonest presenting complaint was bone pain followed by fever, CKD and bleeding disorder. Common clinical findings were anemia, osteolytic lesions and renal insufficiency. M band was seen in 83% of patients on serum protein electrophoresis. On bone marrow examination, majority (53%) of patients had plasmablastic morphology while, 47% had plasmacytic features. Diffuse pattern of infiltration on bone marrow biopsy was observed most commonly in 68.3%patients. Conclusion:The present study concluded that multiple myeloma is a disease of middle age and elderly with male preponderance. The clinical presentation varies with bone pain being the most common presenting complaint. Morphologically,plasmablastic morphology predominated on bone marrow aspiration while diffuse pattern of infiltration was observed on bone marrow biopsy.

A Clinical and Laboratory Profile of Multiple Myeloma

“…But Chowdhury et al 20 Table II: Clinical features of multiple myeloma subjects most common physical findings in this study. In the study of Kaushik et al 21 pallor was seen in 94% of the patients which is similar to this study. But it was 44.2% patients in the study of Sultan et al 18 Bone tenderness was in 47% cases observed by Kaushik et al 21 It was lower than the findings in this study possibly due to late stage of presentation in our study.…”

“…This is consistent with some other studies in the literature. 1,21,24 In our study compression fracture was observed in 21.88% of the patients, which is similar to Kyle et al 1 (22%) study. In our study osteoporosis was found in 12.5% cases.…”

“…It is lower in comparison to the studies of Kaur et al 17 (75%) and Subramanian et al 23 (71%) and higher than the studies of Kalita et al 24 (33%) and Diwan et al 22 (25%) studies. But it is nearly similar to studies of Gupta et al 25 (40%) and Kaushik et al 21 (45%) studies. The anemia was normochromic normocytic in most of our patients.…”

“…In our study osteoporosis was found in 12.5% cases. It was found in 23%, 20%, 52% patients in the studies of Kyle et al 1 , Kaushik et al 21 and Kalita et al 24 respectively. In 12.5% of our patients radiological findings were normal, but in the study of Kyle et al 1 radiological findings were found normal in 21% cases.…”

Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reported

“…Bone lesions visualized on a conventional radiograph, which may include osteolytic lesions or the presence of fractures, are described in 80% of patients at the time of diagnosis. A record similar to that found in this study (74%), where injuries also predominated osteolytic 26 .…”