Multiple motor innervation of individual muscle fibers in the M. tibialis anterior of the dog

Walker, Leon B.

doi:10.1002/ar.1091390102

Cited by 5 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, we found that many muscle fibers (>30%) possessed two or rarely three neuromuscular junction sites (endplates). Other studies have made note of multiple-endplate muscle fibers, especially in facial and neck muscles (Agduhr, 1919; Bendiksen et al, 1981; Brown et al, 1976; Cattell, 1928; Duxson & Sheard, 1995; Happak et al, 1997; Hunt & Kuffler, 1954; Iwasaki, 1957; Jarcho et al, 1952; Bernhard Katz & Kuffler, 1941; Lateva et al, 2002; Périé et al, 1997; Rossi & Cortesina, 1965; Sandmann, 1885; Walker, 1961; Zenker et al, 1990). The interscutularis muscle is also a neck muscle.…”

Section: Discussionmentioning

confidence: 99%

Neuromuscular connectomes across development reveal synaptic ordering rules

Meirovitch

Kang

Draft

et al. 2021

Preprint

View full text Add to dashboard Cite

The connections between motor neurons and muscle fibers are dramatically reorganized in early postnatal life. This work attempts to better understand this synaptic rewiring by using a connectomic approach, i.e., tracing out all the connections between motor neurons and muscle fibers, at successive ages in a small mouse muscle. We reconstructed 31 partial-complete neuromuscular connectomes, using serial section scanning electron microscopy in a neonatal mouse and Brainbow-based and XFP-based fluorescent reconstructions in older animals. Our data included a total of more than 6000 neuromuscular junctions (NMJs), including complete connectomes from one newborn, seven developmental ages (P6-P9), and two adults. Analysis confirmed the massive rewiring that takes place as axons prune their motor units but add more synaptic areas at the NMJs with which they remain in contact. Interestingly, we found synaptic ordering rules that likely underlie this circuit maturation and yield the resulting adult neuromuscular pattern, as manifest in Henneman's size principle. In particular, by analyzing both the identities of axons sharing NMJs at developing ages and muscle fibers with multiple endplates, we found evidence suggesting an activity-based linear ranking of motor neurons such that neurons co-innervated the same endplates and same muscle fibers (if there were more than one endplate) when the axons were similar in activity and hence rank. In addition, this ranking provided a means for understanding action at a distance in which the activity at one neuromuscular junction can impact the fate of the axons at another junction at a different site on the same muscle fiber. These activity-dependent mechanisms provide insight into the means by which timing of activity among different axons innervating the same population of cells, that start out with nearly all-to-all connectivity, can produce a well-organized system of axons, a system that is necessary for the recruitment order of neurons during a graded behavior like muscle contraction.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuromuscular connectomes across development reveal synaptic ordering rules

Meirovitch

Kang

Draft

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Muscle, the Motor

Partridge

Benton

1981

Comprehensive Physiology

View full text Add to dashboard Cite

The sections in this article are: Representation of Muscle Properties Dimensions Used Models Real Motor Systems Summary Properties of the Contractile Unit Passive Mechanical Contributions Response to Neural Signals Interaction Between Neural and Other Inputs Functional Variations Summary Multiple Units of Muscle The Unit of Muscle Function Relationships in Multiunit Function Summary Some Measures of Muscle Function Summary Motor Functions of Muscles Final Summary Epilogue Appendix Units for Measure of Motor Function

show abstract

Effect of histamine on the diameter of skeletal muscle fibers in mice

O'Steen

1964

Experientia

View full text Add to dashboard Cite

Multiple motor innervation of individual muscle fibers in the M. tibialis anterior of the dog

Cited by 5 publications

References 20 publications

Neuromuscular connectomes across development reveal synaptic ordering rules

Neuromuscular connectomes across development reveal synaptic ordering rules

Muscle, the Motor

Effect of histamine on the diameter of skeletal muscle fibers in mice

Contact Info

Product

Resources

About