Multiple morphologies of aggregates from block copolymers containing glycopolymer segments

Li, Zi‐Chen; Liang, Yu-Zeng; Li, Fu‐Mian

doi:10.1039/a905114g

Cited by 66 publications

(58 citation statements)

References 16 publications

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“…Li et al synthesized a series of amphiphilic block copolymers consisting of hydrophobic PS and hydrophilic poly(2-(-D-glucopyranosyloxy)ethyl acrylate) (PGEA) blocks using atom transfer radical polymerization (ATRP) [85,86]. Copolymers were first dissolved in a common solvent (N,N-dimethylformamide, tetrahydrofuran, dioxane, and their mixtures), followed by the addition of water to induce self-assembly.…”

Section: Formation Of Polymersomes From Polymers Comprising Biofunctimentioning

confidence: 99%

Functionalization of Block Copolymer Vesicle Surfaces

et al. 2011

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Abstract:In dilute aqueous solutions certain amphiphilic block copolymers self-assemble into vesicles that enclose a small pool of water with a membrane. Such polymersomes have promising applications ranging from targeted drug-delivery devices, to biosensors, and nanoreactors. Interactions between block copolymer membranes and their surroundings are important factors that determine their potential biomedical applications. Such interactions are influenced predominantly by the membrane surface. We review methods to functionalize block copolymer vesicle surfaces by chemical means with ligands such as antibodies, adhesion moieties, enzymes, carbohydrates and fluorophores. Furthermore, surface-functionalization can be achieved by self-assembly of polymers that carry ligands at their chain ends or in their hydrophilic blocks. While this review focuses on the strategies to functionalize vesicle surfaces, the applications realized by, and envisioned for, such functional polymersomes are also highlighted.

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Section: Formation Of Polymersomes From Polymers Comprising Biofunctimentioning

confidence: 99%

Functionalization of Block Copolymer Vesicle Surfaces

et al. 2011

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“…A lot of glycopolymers with carbon-carbon bonds in the main chains have been synthesized and their properties such as surface activity, aggregation behaviors, and thermal degradation have been investigated over the past decades. [3][4][5][6][7][8] However, this kind of amphiphilic glycopolymers have some disadvantages, for example not biodegradable and have low surface activity, so they may be limited in many applications. [9] Thus, the synthesis of biodegradable glycopolymers with high surface activity will become increasingly important.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Surface and Spreading Properties of Lactobionamide-Grafted Amphiphilic Glycopolysiloxanes

Zhang

Wang

et al. 2013

Journal of Dispersion Science and Technology

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Three lactobionamide-grafted amphiphilic glycopolysiloxanes (LBPS) were synthesized using a two-step method. First, the aminopropyl functional polysiloxanes (APSO) were synthesized by equilibrium polymerization; then, lactobionic acid was conjugated to the APSO to give the glycopolysiloxanes LBPS. The final compositions of the amphiphilic glycopolysiloxanes were characterized by FTIR and 1 H NMR. Surface activities and spreading behaviors in aqueous solution of these three glycopolysiloxanes were investigated by surface tension measurements and contact angle measurements. The results show that these three glycopolysiloxanes have much higher surface activity than those of conventional carbon-carbon chain glycopolymers in aqueous solution and the spreading ability of three lactobionamide-grafted amphiphilic glycopolysiloxanes solution on low-energy surfaces is not only solely dependent on surface tension, but also dependent on hydrophilic-lipophilic balance of surfactant.

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“…We are interested in introducing glycopolymer as the hydrophilic segment in amphiphilic block copolymers to endow the block copolymers with new properties such as biocompitability. It is also expected that these amphiphilic block copolymers may self-assemble into ordered aggregates in solution, and they make it possible to study the specific interaction of these aggregates with lectins, or to use them as materials for drug delivery systems 11) . But for block copolymers containing a well-defined glycopolymer segment, only a few are available until now [12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of amphiphilic block copolymers with well‐defined glycopolymer segment by atom transfer radical polymerization

Liang

Chen

et al. 2000

Macromol. Rapid Commun.

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Multiple morphologies of aggregates from block copolymers containing glycopolymer segments

Abstract: Multiple morphologies of aggregates (micelle-like spheres, vesicles, tubules) from well-defined polystyrene-b-poly[(2-bd-glucopyranosyloxy)ethyl acrylate] (PS-b-PGEA) diblock copolymers in diluted aqueous solutions were observed by transmission electron microscopy.

Cited by 66 publications

References 16 publications

Functionalization of Block Copolymer Vesicle Surfaces

Functionalization of Block Copolymer Vesicle Surfaces

Synthesis, Surface and Spreading Properties of Lactobionamide-Grafted Amphiphilic Glycopolysiloxanes

Synthesis of amphiphilic block copolymers with well‐defined glycopolymer segment by atom transfer radical polymerization

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