Multiple Minute Digitate Hyperkeratosis in an Infant

Abstract

A distinct variant of multiple minute digitate hyperkeratoses in a healthy 4-month-old boy, exclusively located in the anogenital area and with a transitory character, is described.

Infantile anogenital digitate keratoses: A case series of a novel entity

“…This condition was previously described only once in the literature in 2016, in a case report by Santiago et al. 4 In our case series and the case report previously cited, there was no history of diarrhea, diaper rash, usage of irritative creams, or any dermatosis in the affected area. All cases occurred in healthy and well-developing infants, without similar family history.…”

“…The previous known case reported by Santiago et al 4 described a healthy 4-month-old boy with multiple small, rough, spiny, non-follicular, yellowish white (1-3 mm) papules in the anogenital area. Histologic examination revealed marked hyperkeratosis with parakeratosis and associated epidermal invagination.…”

“…Santiago et al 4 considered their case of DK in the perianal region of an infant as a subtype of MMDH. However, due to the different histology, the follicular vs non-follicular tendency, distribution, age of onset, and transient character, we argue that IADK is not a subtype of MMDH, but rather a different subtype of DK.…”

Spiny papules on the chest and periaxillary region

“…First described by Goldstein in 1967, multiple minute digitate hyperkeratosis (MMDH) is a rare, nonfollicular keratinization dermatitis of unknown etiology with approximately 30 cases reported in English literature 1,2 . Histopathologically finger‐like projections of orthohyperkeratosis arising from a tented acanthotic epidermis, as in our case, are observed 3 .…”

A Case of Unilateral Focal Hyperkeratosis

“…1 To our knowledge, only 27 female and 11 male cases of MMDH have been reported worldwide, with age at onset ranging from 4 months to 83 years, including this case. 2,3 Several synonymous terms for MMDH exist in the medical literature (eg, familial disseminated piliform hyperkeratosis, disseminated spiked hyperkeratosis, minute aggregate keratosis). 4 Multiple minute digitate hyperkeratosis is characterized by multiple submillimeter spiky projections or spicules, usually located on the trunk and limbs in a symmetrical nonfollicular distribution, classically sparing the face and palmoplantar surfaces.…”