Multiple Metastatic Malignant Melanoma Presenting Intraluminal Gallbladder Bleeding

Onozawa, Hisashi; Saito, Motonobu; Yoshida, Sayaka; Sakuma, Toshiharu; Matsuzaki, Masami; Katagata, Naoto; Watanabe, Fumiaki; Yamaguchi, Yoshiko; Takenoshita, Seiichi; Nomizu, Tadashi

doi:10.9738/intsurg-d-13-00143.1

Cited by 13 publications

(11 citation statements)

References 14 publications

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“…When symptoms are present, the most common is upper abdominal pain resembling cholecystolithiasis; cases of hemobilia and biliary fistula have also been described [2,8,9,17].…”

Section: Discussionmentioning

confidence: 95%

Metastatic melanoma of the gallbladder: report of two cases and a review of the literature

et al. 2015

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Melanoma is one of the most aggressive and highly metastatic cancers. The most common sites of distant metastases are soft tissues, lung, liver, skin and brain, whereas only few patients develop gastrointestinal metastases. Metastatic involvement of the gallbladder is rare and more often part of a widespread disease than a solitary lesion. The "gold-standard" treatment of metastatic melanoma of the gallbladder remains unclear. We report two cases of patients with past history of cutaneous melanoma who developed visceral metastases. The first patient was asymptomatic and had a widespread disease with metastatic involvement of both the spleen and the gallbladder. The second patient had an isolated metastasis of the gallbladder and complained of upper abdominal pain. The chosen treatment was open cholecystectomy (and splenectomy) in the first case and laparoscopic cholecystectomy in the second. A review of the literature is provided.

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“…When symptoms are present, the most common is upper abdominal pain resembling cholecystolithiasis; cases of hemobilia and biliary fistula have also been described [2,8,9,17].…”

Section: Discussionmentioning

confidence: 95%

Metastatic melanoma of the gallbladder: report of two cases and a review of the literature

et al. 2015

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“…In a minority of cases, metastasis to the gallbladder are symptomatic. The most common presentations are epigastric and right upper quadrant pain mimicking acute cholecystitis, obstructive jaundice, and more rarely haemobilia and external biliary fistula formation [ 16 ]. Radiological findings are fundamental to help in diagnostic process.…”

Section: Discussionmentioning

confidence: 99%

Malignant metastatic melanoma to the gallbladder: Report of a peculiar case

Buono

Maienza

Rinaldi

et al. 2020

International Journal of Surgery Case Reports

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Highlights Melanoma is one of the most aggressive and one of the fastest growing types of cancer. The gallbladder envolvement from a metastatic cutaneous malignant melanoma is a highly uncommon finding, usually associated with diffuse metastatic disease and observed during autopsy. We report a case of a 35-years old Caucasian woman with isolated metastasis of gallbladder form cutaneous primary malignant melanoma underwent to laparoscopic cholecystectomy. Malignant cutaneous melanoma is a skin cancer characterized by the highest mortality. Isolated metastasis of gallbladder are barely described and mostly present in a widespread metastatic disease. Surgical treatment is indicated considering the extension of the disease and the clinical status of the patient.

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“…Acute emphysematous cholecystitis at presentation may also mimic uncomplicated acute cholecystitis [ 8 , 12 ]. The dangerous emphysematous form can also present with nonspecific chronic or subacute upper abdominal pain, jaundice due to bile duct obstruction or the hemolytic effect of clostridia species [ 13 , 14 ], the unexpected imaging finding of air in the gallbladder wall, a polypoid lesion or biliary fistula on imaging [ 15 ], or GI bleeding from an ischemic or necrotic gallbladder source, termed “hemobilia” [ 16 , 17 ]. Other uncommon presentations include hypotension, isolated fever, or sepsis.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Gallbladder Melanoma Presenting as Acute Emphysematous Cholecystitis

Hall

Grenier

Shah

et al. 2018

Case Reports in Medicine

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Malignant melanoma is an aggressive tumor with a high potential for distant metastases, including spread to the gallbladder where it represents more than half of all metastases detected at autopsy. Yet, it is rarely symptomatic in life and is a rare cause of acute cholecystitis. Emphysematous cholecystitis is a rare, potentially fatal variant of acute cholecystitis characterized by the presence of gas in the gallbladder lumen or wall. We report a 77-year-old woman with acute emphysematous cholecystitis as the initial feature of recurrent melanoma metastatic to the gallbladder. This exceptional association highlights the need to consider a relapse of malignancy when assessing unexplained abdominal symptoms in any patient with a prior history of melanoma.

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Multiple Metastatic Malignant Melanoma Presenting Intraluminal Gallbladder Bleeding

Cited by 13 publications

References 14 publications

Metastatic melanoma of the gallbladder: report of two cases and a review of the literature

Metastatic melanoma of the gallbladder: report of two cases and a review of the literature

Malignant metastatic melanoma to the gallbladder: Report of a peculiar case

Metastatic Gallbladder Melanoma Presenting as Acute Emphysematous Cholecystitis

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