Multiple Metastatic Leiomyosarcoma of the Pancreas: A First Case Report and Review of the Literature

Ogura, Takeshi; Masuda, Daisuke; Kurisu, Yoshitaka; Miyamoto, Yoshiharu; Hayashi, Michihiro; Imoto, Akira; Takii, Michiaki; Takeuchi, Toshihisa; Inoue, Takuya; Tokioka, Satoshi; Uchiyama, Kazuhisa; Umegaki, Eiji; Higuchi, Kazuhide

doi:10.2169/internalmedicine.52.8594

Cited by 13 publications

(10 citation statements)

References 26 publications

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“…Although primary pulmonary LMS are rare [3], pulmonary or bone metastases are a frequent finding in affected patients [4]. A typical feature of LMS is the long latency of metastatic lesions after resection of the primary tumor [5,6]. LMS manifestation in the pancreas is extremely rare and has only been reported in few cases and series up to now (▶ Table 1, 2).…”

Section: Discussionmentioning

confidence: 99%

An unusual hypoechoic solid mass in the pancreatic head

et al. 2017

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Solid pancreatic lesions found on imaging procedures are suspicious for malignancy and, therefore, demand immediate diagnostic evaluation and therapy. In the case of indeterminate histology, a primary resection should be considered in order to preserve the possibility of curative surgery, although rare entities may be initially disregarded. We present here the case of a 48-year-old female patient with a hypoechoic lesion of the pancreatic head, which was clearly delineated from the surrounding pancreatic tissue. The challenging diagnosis of metastatic leiomyosarcoma could only be established by considering the long-term clinical history and former histology specimens.

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Section: Discussionmentioning

confidence: 99%

An unusual hypoechoic solid mass in the pancreatic head

et al. 2017

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“…Moreover, metastatic leiomyosarcoma isolated to the pancreas from a distant primary tumor site is extremely rare [27]. …”

Section: Discussionmentioning

confidence: 99%

Primary Leiomyosarcoma of the Pancreas—a Case Report and a Comprehensive Review

Søreide

Undersrud

Al-Saiddi

et al. 2016

J Gastrointest Canc

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PurposePrimary mesenchymal tumors of the pancreas are rare, with leiomyosarcomas the most encountered entities among the pancreatic sarcomas. With few exceptions, single case reports published over the last six decades constitute the entire scientific literature on this topic. Thus, evidence regarding clinical decision-making is scant.MethodsBased on a case report and an extensive literature search in PubMed, we discuss the clinical aspects and current management of this rare malignancy.ResultsWe identified only two papers with more than a single case presentation; these institutional patient series were limited to five and nine patients. Additionally, a few papers sought to summarize the individual case reports published in the English and/or Chinese language. The clinical presentation is rather non-specific. Moreover, modern imaging modalities are insufficiently accurate to diagnose leiomyosarcoma of the pancreas. Treatment goals include a complete resection with free margins. Proper morphologic examination using immunohistochemistry and the application of a grading system are clinically important for prognostication. The efficacy of adjuvant treatments has not been established.ConclusionPrimary pancreatic leiomyosarcoma is extremely rare, and the scientific literature is primarily based on single case reports. Conclusions on management and prognosis should be drawn with caution. A multidisciplinary team consultation is warranted to discuss a thorough individual treatment plan based on the available scientific literature, despite its low evidence level.

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“…A case of pancreatic metastasis from a uterine LMS is rare [28,29]. Ogura et al identified, in a literature review, 25 cases of LMS metastases to the pancreas, of which 7 cases were from a primary uterine tumor [30].…”

Section: Discussionmentioning

confidence: 99%

Extensively Metastatic Vaginal Stump Leiomyosarcoma after Total Hysterectomy: A Rare Presentation—A Case Report with Review of Literature

Singhal

Jain

Saxena

et al. 2015

Indian J Gynecol Oncolog

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The incidence of leiomyosarcoma in uterine leiomyomas is estimated to be between 0.13 and 0.29 % [1]. However, the exact incidence of leiomyosarcoma in uteri removed with a pre-operative diagnosis of benign uterine leiomyomas has not been previously reported. In our study, we describe a case of a 58-year-old female who underwent total hysterectomy 10 years back for uterine leiomyoma and now presented to us with complaints of multiple body swellings over abdomen, arms, neck, scalp, and proptosis. On computed tomography, it was seen that there was a mass in abdomen arising from vaginal stump involving bladder, rectum with skin, muscle, omental, lung, liver, adrenal, and retroperitoneal metastases. Excisional biopsy from a parietal wall swelling and punch biopsy from the vaginal stump were taken. The final histopathological report confirmed it to be leiomyosarcoma with metastases all over the body. Combination chemotherapy of gemcitabine and docetaxel was given to patient. Patient responded to treatment on a 6 month follow-up.

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Multiple Metastatic Leiomyosarcoma of the Pancreas: A First Case Report and Review of the Literature

Cited by 13 publications

References 26 publications

An unusual hypoechoic solid mass in the pancreatic head

An unusual hypoechoic solid mass in the pancreatic head

Primary Leiomyosarcoma of the Pancreas—a Case Report and a Comprehensive Review

Extensively Metastatic Vaginal Stump Leiomyosarcoma after Total Hysterectomy: A Rare Presentation—A Case Report with Review of Literature

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