Multiple Metastatic Calcifications Detected by Bone Scintigraphy and Demonstrated by CT

Imanishi, Yoshimasa; Kishiro, Masaki; Miyazaki, Osamu; Toyokawa, Tatsuki; Kuroki, Kazunori; Haji, Hitoshi; Ishikawa, Tohru

doi:10.1097/00003072-199202000-00010

Cited by 14 publications

(5 citation statements)

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“…Skin biopsies are frequently used to obtain the correct diagnosis with the most common histopathological finding consisting of calcifying panniculitis. [13] Comparison of bone scan findings with CT have previously been reported[14] but not the use of hybrid imaging, to the best of our knowledge.…”

Section: Resultsmentioning

confidence: 99%

The role of bone scintigraphy with single-photon emission computed tomography-computed tomography in the diagnosis and evaluation of calciphylaxis

2017

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Calciphylaxis, also known as calcific uremic arteriolopathy, is an uncommon disease, typically found in patients with the end-stage renal disease. Pathophysiological features include small vessel vasculopathy with mural calcification, fibrosis, and thrombosis. The clinical presentation varies but often consists of the necrosis of skin and subcutaneous tissues, with or without visceral organ involvement due to small vessel vasculopathy. This condition has a significant morbidity and mortality, making accurate diagnosis imperative. We present a case of calciphylaxis investigated using planar bone scintigraphy and single-photon emission computed tomography-computed tomography (SPECT-CT). This case stresses the value of SPECT-CT to accurately localize the abnormal uptake in subcutaneous soft tissue microcalcifications and confirms the exact location and extent of pathology.

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Section: Resultsmentioning

confidence: 99%

The role of bone scintigraphy with single-photon emission computed tomography-computed tomography in the diagnosis and evaluation of calciphylaxis

2017

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“…Computed tomography scan is very sensitive in depicting the lesions as increased densities, and is used to evaluate the disease burden. 11,25,26 Lesion biopsy and histopathological examination remain the definitive diagnosis of calcinosis. Endoscopic evidence of gastric calcifications appears as 1- to 5-mm white flat plaques or nodules in the gastric fundus, body, and/or antrum.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Calcinosis of Gastric Mucosa

Kosuru

Mohammed

Kapoor

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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Calcinosis cutis refers to the deposition of calcium salts in the cutaneous and subcutaneous tissue and is frequently associated with inflammation. Gastric calcinosis can be classified into metastatic, dystrophic, and idiopathic; metastatic calcinosis is the most common type. In metastatic calcification, calcium salts are deposited in normal soft tissues in the setting of altered metabolism of serum calcium and phosphorus and is a rare and serious complication of chronic renal failure. The important factors contributing to the development of metastatic calcinosis are hypercalcemia, hyperphosphatemia, and an elevated calcium-phosphate product. The most striking feature of this diagnosis is the calcification around the large joints. While it mostly involves dermis of small and medium-sized vessels, it can rarely affect the mucosal layers of the gastrointestinal (GI) tract. Calcinosis presents as a marker for the presence of calcifications in other organs, such as heart or lung, which can be life-threatening. Patients rarely present with clinical symptoms of GI upset, dyspepsia, or epigastric pain that are attributed to calcinosis. If patients present with GI symptoms, infectious causes remain to be higher on the differential. We present a case of incidental finding of gastric mucosal calcinosis during the workup and treatment of dysphagia.

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“…[141516] It is more sensitive and can pick up micro-calcification, not detected by conventional imaging modalities. Our case did not show any significant calcification in lungs, liver, or stomach on CT scan.…”

Section: Discussionmentioning

confidence: 99%

Extensive visceral calcification demonstrated on ^99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy

Gandhi¹,

Rabadiya²

2017

Indian J Nucl Med

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Hypercalcemia is a common life-threatening complication associated with several malignancies. Parathyroid-related peptide has been shown to cause hypercalcemia in several solid tumors but rarely in penile cancer. We report a case of penile cancer with hypercalcemia causing metastatic visceral calcification in lungs, liver, and stomach detected on bone scan without significant abnormalities on CT scan.

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Multiple Metastatic Calcifications Detected by Bone Scintigraphy and Demonstrated by CT

Cited by 14 publications

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The role of bone scintigraphy with single-photon emission computed tomography-computed tomography in the diagnosis and evaluation of calciphylaxis

The role of bone scintigraphy with single-photon emission computed tomography-computed tomography in the diagnosis and evaluation of calciphylaxis

Metastatic Calcinosis of Gastric Mucosa

Extensive visceral calcification demonstrated on ^99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy

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Multiple Metastatic Calcifications Detected by Bone Scintigraphy and Demonstrated by CT

Cited by 14 publications

References 0 publications

The role of bone scintigraphy with single-photon emission computed tomography-computed tomography in the diagnosis and evaluation of calciphylaxis

The role of bone scintigraphy with single-photon emission computed tomography-computed tomography in the diagnosis and evaluation of calciphylaxis

Metastatic Calcinosis of Gastric Mucosa

Extensive visceral calcification demonstrated on 99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy

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Extensive visceral calcification demonstrated on ^99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy