Multiple metal exposures and their correlation with monoamine neurotransmitter metabolism in Chinese electroplating workers

Wu, Linlin; Gong, Wei; Shen, Sipeng; Wang, Zhonghe; Yao, Jiaxi; Wang, Jun; Yu, Jing; Gao, Rong; Wu, Gang

doi:10.1016/j.chemosphere.2017.04.112

Cited by 19 publications

(7 citation statements)

References 42 publications

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“…We observed a higher-intensity signal for 3,4-dihydroxyphenylacetaldehyde-a metabolite of oxidative deamination of dopamine, which generates a free radical and stimulates the activation of mitochondrial permeability transition and consequently leads to neuron death [25]. Wu et al [26] analyzed multiple metal exposures (titanium, vanadium, chromium, manganese, iron, cobalt, nickel, copper, zinc, arsenic, cadmium and lead) in Chinese electroplating workers, and correlations were observed in the urinary concentrations of twelve main neuroactive metabolites related to dopamine, serotonin and kynurenine pathways. In exposed workers (detailed descriptions of the studied group and performed activities, e.g., how close workers were to the chrome bath, are lacking), the urinary concentration of vanadium, manganese, cobalt, nickel, copper, zinc, arsenic and cadmium were significantly higher than in the control group, but unexpectedly, Cr concentrations in the Chinese electroplaters were at a similar level as in the control group.…”

Section: Tyrosine Tryptophan and Other Amino Acid Metabolismmentioning

confidence: 80%

HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium

et al. 2022

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Exposure to hexavalent chromium Cr(VI) may occur in several occupational activities, placing workers in many industries at risk for potential related health outcomes. Untargeted metabolomics was applied to investigate changes in metabolic pathways in response to Cr(VI) exposure. We obtained our data from a study population of 220 male workers with exposure to Cr(VI) and 102 male controls from Belgium, Finland, Poland, Portugal and the Netherlands within the HBM4EU Chromates Study. Urinary metabolite profiles were determined using liquid chromatography mass spectrometry, and differences between post-shift exposed workers and controls were analyzed using principal component analysis. Based on the first two principal components, we observed clustering by industrial chromate application, such as welding, chrome plating, and surface treatment, distinct from controls and not explained by smoking status or alcohol use. The changes in the abundancy of excreted metabolites observed in workers reflect fatty acid and monoamine neurotransmitter metabolism, oxidative modifications of amino acid residues, the excessive formation of abnormal amino acid metabolites and changes in steroid and thyrotropin-releasing hormones. The observed responses could also have resulted from work-related factors other than Cr(VI). Further targeted metabolomics studies are needed to better understand the observed modifications and further explore the suitability of urinary metabolites as early indicators of adverse effects associated with exposure to Cr(VI).

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Section: Tyrosine Tryptophan and Other Amino Acid Metabolismmentioning

confidence: 80%

HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium

et al. 2022

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“…Exposure to Pd, Cd, and Ni may increase the activation of the enzyme MAO-A in the neurotransmitter [19], which regulates metabolism and catalyzes oxidizing reactions into the metabolism of neurotransmitters. Monoamines include doptopinephrine, epinephrine, and serotonin [20,21] by Jaya Parasanthi et al [22]. In mice, damage to serotonin-producing neuron tissues was found, so MAO-A may play an essential role in activating several neurotransmitters, including serotonin [23].…”

Section: Introductionmentioning

confidence: 99%

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Harasarn

Phatrabuddha

Kaewkaen

et al. 2022

Rocz Panstw Zakl Hig

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Background. E-waste sorting workers usually separate electronic waste. Therefore, they can be exposed to heavy metals. Objectives. This study compared monoamine oxidase (MAO) levels affected by the levels of lead (Pb), cadmium (Cd), and nickel (Ni) in the blood and their workplace among e-waste sorting workers (EWSW). Material and methods. The exposed group included 76 EWSW, and the non-exposed group included 49 village health volunteers. An interview form was used to assess the risk factors. We measured Pb, Cd, and Ni on the work surfaces and in the blood, and MAO levels as a neurological enzymes. Results. Among the EWSW, 42 were males (55.3%), and the mean age (SD) 48.0 (12.64) years, and income were 156.37 ± 88.08 USD. In the work areas of the exposed group, the concentration of Pb, Cd, and Ni were 245.042 (± 613.910), 0.375 (± 0.662), and 46.115 (± 75.740) μg/100 cm2, respectively, while the non-exposed group, the concentration of Pb, Cd, and Ni were 0.609 (± 0.934), 0.167 (± 1.171) and 1.020 (± 0.142) μg/100 cm2. Pb and Ni concentrations in the workplace of the exposed groups were statistically different from that of the non-exposed group. Pb, Cd, and Ni concentrations in serum were 6.411 ± 1.492 μg/dL, 0.9480 ± 0.350 μg/L, 2.568 ± 0.468 μg/L, respectively, while in the non-exposed group, the heavy metal concentrations were 6.411 ± 1.620 μg/dL, 0.909 ± 0.277 μg/L, 2.527 ± 0.457 μg/L. The MAO in the exposed group was 362.060 ± 97.981 U/L, while that in the non-exposed group was 369.771 ± 86.752 U/L. Moreover, MAO concentration was significantly different from Ni concentration (p < 0.05). Conclusion. The electronic waste sorting workers should clean their work areas to reduce the Pb, Cd, and Ni levels on the working surfaces, and health surveillance should be performed.

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“…Moreover, deficiency of a certain neurotransmitter could lead to a certain depressive symptom (23). Studies have reported that brain iron deposits could affect monoamine function (24). Therefore, brain iron deposits might reduce the activity of monoamines, leading to the occurrence of depressive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Brain Iron Deposits in Thalamus Is an Independent Factor for Depressive Symptoms Based on Quantitative Susceptibility Mapping in an Older Adults Community Population

Zhang

Zhou

et al. 2019

Front. Psychiatry

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Objectives: With the trend of an aging population, an increasing prevalence of late-life depression has been identified. Several studies demonstrated that iron deposition was significantly related to the severity of symptoms in patients with depression. However, whether brain iron deposits influence depressive symptoms is so far unclear in the community of older adults. We measured iron deposition in deep intracranial nucleus by quantitative susceptibility mapping (QSM) and aimed to explore the relationship between iron deposition and depressive symptoms. Methods: We reviewed the data of a community population from CIRCLE study, which is a single-center prospective observational study that enrolled individuals above 40 years old with cerebral small vessel disease (SVD), while free of known dementia or stroke. We evaluated regional iron deposits on QSM, measured the volume of white matter hyperintensities (WMHs) on T2 fluid-attenuated inversion recovery, and assessed depressive symptoms by Hamilton depression scale (HDRS). We defined depressive symptom as HDRS > 7. Results: A total of 185 participants were enrolled. Participants in depressive symptom group had higher QSM value in thalamus than control group (18.79 ± 14.94 vs 13.29 ± 7.64, p = 0.003). The QSM value in the thalamus was an independent factor for the presence of depressive symptoms (OR = 1.055; 95% CI: 1.011-1.100; p = 0.013). The regional QSM values in other areas were not associated with HDRS score (all p > 0.05). No significant correlations were observed between WMHs volume and HDRS score (p > 0.05), or regional QSM values and WMHs volume (all p > 0.05). Conclusions: Our study demonstrated that iron deposits in the thalamus were related to the depressive symptoms in older adults.

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Multiple metal exposures and their correlation with monoamine neurotransmitter metabolism in Chinese electroplating workers

Cited by 19 publications

References 42 publications

HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium

HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Brain Iron Deposits in Thalamus Is an Independent Factor for Depressive Symptoms Based on Quantitative Susceptibility Mapping in an Older Adults Community Population

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