Multiple meningiomas: A clinical, surgical, and cytogenetic analysis

NF2 gene mutations and allelic status of 1p, 14q and 22q in sporadic meningiomas

“…The current WHO grading system comprises three grades as follows: most meningiomas are slow growing, are generally considered benign tumors, and correspond to grade I (typical meningiomas); about 10% of cases are classi®ed as grade II (atypical) or anaplastic/malignant (grade III), exhibiting more aggressive clinical behaviour, with a higher risk of recurrence when compared to typical grade I meningiomas (Kleihues et al, 1993). These neoplasms are usually sporadic, but a few families have been described with multiple tumors inherited in an autosomal dominant fashion (Memon, 1980;Battersby et al, 1986;Butti et al, 1989;Domenicucci et al, 1989), and they also occur in as many as half of the patients with the dominantly inherited familial neuro®bromatosis type 2 syndrome (NF2) (Martuza and Eldridge, 1988). Using positional cloning approaches, the candidate gene for NF2 has been isolated from chromosome 22q12 region (Rouleau et al, 1993;Trofatter et al, 1993), and mutations have been observed in both germ-line of NF2 patients and in about 30% of sporadic meningiomas Lekanne-Deprez et al, 1994;Merel et al, 1995;Papi et al, 1995;De Vitis et al, 1996;Harada et al, 1996).…”

Multiple intracranial meningiomas: diagnosis, biological behavior and treatment

“…Intracranial meningiomas incidence rate varies from 13 to 20%. But MIM's are rare, when not associated with neurofibromatosis [4][5][6][7][8][9][10][11]13 . The first quotations reveal an incidence of only 1 to 2%.…”

“…Meningiomas are tumors originated from arachnoidal cells present in the villi, in the granulations, in the stroma of the perivascular spaces and in the choroid plexus; corresponding to 13 to 20% of all intracranial tumors [1][2][3] . Multiple intracranial meningiomas (MIM), when not associated with neurofibromatosis, are a rare event, which corresponding to 2.3 to 8.9% of all intracranial meningiomas [4][5][6][7][8][9][10][11] . The multiple intracranial meningiomas terminology should be used only when two or more meningiomas occur either simultaneously or sequentially in different locations.…”

“…The multiple intracranial meningiomas terminology should be used only when two or more meningiomas occur either simultaneously or sequentially in different locations. It is important to establish the difference between this pathology and tumor recurrence or diffuse meningiomatosis 1,3,4,[7][8][9][10] . our study aims presenting, analyzing and discussing 7 patients diagnosed with multiple intracranial meningiomas, describing their clinical, radiological, and histological characteristics, as well as their biological behavior.…”

“…Multiple intracranial meningiomas (MIM), when not associated with neurofibromatosis, are a rare event, which corresponding to 2.3 to 8.9% of all intracranial meningiomas [4][5][6][7][8][9][10][11] .…”