Multiple Memory Deficits in Patients With Multiple Sclerosis

Litvan, Irene; Grafman, Jordan; Vendrell, Pere; Jm, Martínez; Junqué, Carme; Jm, Vendrell; Jl, Barraquer-Bordas

doi:10.1001/archneur.1988.00520300025012

Cited by 147 publications

(90 citation statements)

References 18 publications

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“…The greater activation inside the right cerebellum in CISSMS patients could be related to a compensatory larger recruitment of a component of the inner speech system during PASAT. This result could be interpreted in the light of previous studies [Litvan et al, 1988;Ruchkin et al, 1994] that suggested impairment of the phonological loop of working memory in clinically definite MS patients.…”

Section: Discussionsupporting

confidence: 77%

Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of multiple sclerosis

Audoin

Ibarrola

Ranjeva

et al. 2003

Human Brain Mapping

252

174

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Recent functional magnetic resonance imaging (fMRI) studies have suggested that functional cortical changes seen in patients with early relapsing-remitting multiple sclerosis (MS) can have an adaptive role to limit the clinical impact of tissue injury. To determine whether cortical reorganization occurs during high cognitive processes at the earliest stage of multiple sclerosis (MS), we performed an fMRI experiment using the conventional Paced Auditory Serial Addition Test (PASAT) as paradigm in a population of ten patients with clinically isolated syndrome suggestive of multiple sclerosis (CISSMS). At the time of the fMRI exploration, mean disease duration was 6.8 Ϯ 3.3 months. We compared these results to those obtained in a group of ten education-, age-, and sex-matched healthy controls. Subjects were explored on a 1.5 T MRI system using single-shot gradient-echo EPI sequence. Performances of the two groups during PASAT recorded inside the MR scanner were not different. Statistical assessment of brain activation was based on the random effect analysis (between-group analysis two-sample t-test P Ͻ 0.005 confirmed by individual analyses performed in the surviving regions P Ͻ 0.05 Mann Whitney U-test). Compared to controls, patients showed significantly greater activation in the right frontopolar cortex, the bilateral lateral prefrontal cortices, and the right cerebellum. Healthy controls did not show greater activation compared to CISSMS patients. The present study argues in favor of the existence of compensatory cortical activations at the earliest stage of MS mainly located in regions involved in executive processing in patients performing PASAT. It also suggests that fMRI can evidence the active processes of neuroplasticity contributing to mask the clinical cognitive expression of brain pathology at the earliest stage of MS. Hum. Brain

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Section: Discussionsupporting

confidence: 77%

Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of multiple sclerosis

Audoin

Ibarrola

Ranjeva

et al. 2003

Human Brain Mapping

252

174

View full text Add to dashboard Cite

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“…propose that EI had a particular interference effect on performance. However, the level of task Moreover, the learning impairment observed in these patients could also be due to the slowed information processing (41) and impaired working memory capacity (42), which can be related to alterations in the functional connectivity patterns involving different neural networks (43)(44)(45). Changes in brain connectivity in MS patients have been shown by diffusion tensor imaging in full (DTI)-based fiber tracking (46)(47) and functional magnetic resonance imaging (MRI) (43,(48)(49).…”

Section: Discussionmentioning

confidence: 99%

Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients

Zahiri

Abollahi

Nabavi

et al. 2017

MJMS

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Original Article Abstract Background: Multiple sclerosis (MS) is the most widespread disabling neurological condition in young adults around the world. The purpose of this study was to investigate the impact of explicit information (EI) on motor-sequence learning in MS patients.Methods: Thirty patients with relapsing-remitting MS (RRMS), age: 29.5 (SD = 5.6) years and 30 healthy gender-, age-, and education-matched control group participants, age: 28.8 (SD = 6.0) years, were recruited for this study. The participants in the healthy group were then randomly assigned into an EI (n = 15) group and a no-EI (n = 15) group. Similarly, the participants in the control group were then randomly assigned into EI (n = 15) and no-EI (n = 15) groups. The participants performed a serial reaction time (SRT) task and reaction times. A retention test was performed after 48 hours.Results: All participants reduced their reaction times across acquisition (MS group: 46.4 (SD = 3.3) minutes, P < 0.001, and healthy group: 39.4 (SD = 3.3) minutes, P < 0.001). The findings for the within-participants effect of repeated measures of time were significant (F (5.06,

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“…4 Cognitive impairment is a common clinical feature of MS at both the earlier and later stages of the disease, 5,6 with prevalence rates ranging from 43% to 70%. 7,8 MS has been shown to affect negatively various aspects of cognitive function including those associated with attention, 9,10 efficiency of information processing, 9,11 executive function, 12 processing speed, 13 new learning and memory. 8,13 Cognitive dysfunction is closely associated with functional status in MS. Rao et al 8 found that individuals with MS who were cognitively impaired participated in fewer social and vocational activities, were less likely to be employed, had greater difficulties in doing routine household tasks, and were more vulnerable to psychiatric illness than individuals with a purely physical disability.…”

Section: Introductionmentioning

confidence: 99%