Multiple melanocytoma of the thoracic spine: a case report and literature review

Wang, Yübo; Wang, Wenjun; Zhao, Haitao; Li, Wei; Peng, Tao; Zhang, Xianfeng

doi:10.1016/j.spinee.2015.09.036

Cited by 10 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microscopically, meningeal melanocytoma, usually appears dark-brown or black, nodular and encapsulated, and demonstrates spindle or epithelioid cells with relatively well-defined eosinophilic cytoplasm, centrally-located vesicular nuclei and brown-pigmented granules. 1,[38][39][40] Ultrastructurally, the meningeal melanocytoma cells are characterized by of polar cytoplasmic processes, scarce zonula adherens and numerous premelanosomes at different stages of differentiation. 41,42 Benign melanocytoma may show an aggressive course to malignancy, and even recur after complete excision.…”

Section: Some Literatures Have Discussed the Impact Of Therapeutic Opmentioning

confidence: 99%

8-Year Follow-up for Woman with Spinal Meningeal Melanocytoma in S1 Nerve Root: Case Report and Literature Review

Yin

et al. 2019

World Neurosurgery

View full text Add to dashboard Cite

Background: Primary melanocytic neoplasms in the central nervous system (CNS) are rare lesions arising from leptomeningeal melanocytes. These lesions produce neural deficits that resemble those of a meningioma or a schwannoma radiologically Case presentation: A tumor around the left S1 root with an extension into the left paraspinal compartment was identified in a 32-year-old female with persistent left leg pain for 6 months. The tumor was hyper-intense on T1-weighted image and hypointense on T2-weighted image with a homogeneous enhancement. The clinical features, radiologic presentations, treatment choice and pathologic characteristic were illustrated. The treatment outcome was compared with those reported in the previous literature. The tumor was en-bloc resected with the S1 nerve root reserved. Grossly, the tumor was a soft, capsulated, wellcircumscribed black pigmented lesion. Immunohistochemistry revealed that the tumor cells were positive for HMB-45, S-100 protein and vimentin. The patient's symptoms were greatly relieved postoperatively. No signs of local recurrence were observed. Conclusion Spinal meningeal

show abstract

Section: Some Literatures Have Discussed the Impact Of Therapeutic Opmentioning

confidence: 99%

8-Year Follow-up for Woman with Spinal Meningeal Melanocytoma in S1 Nerve Root: Case Report and Literature Review

Yin

et al. 2019

World Neurosurgery

View full text Add to dashboard Cite

show abstract

“…Primary malignant melanoma of the central nervous system (CNS) is a very rare tumor, accounting for~1% of all cases of melanoma, and primary spinal cord melanoma is rarely encountered. Multifocal primary melanocytic tumor is extremely rare [2].…”

Section: Discussionmentioning

confidence: 99%

“…Since the first report by Hirschberg in 1906,~60 cases of primary spinal melanoma have been reported in the English literature [1]. To date, there have been only four previous reports of multifocal primary melanocytic tumors [2].…”

Section: Introductionmentioning

confidence: 99%

Multifocal primary melanoma of the cervical spinal cord successfully treated by tumorectomy: a case report

Iga

Iwanami

Funakoshi

et al. 2018

Spinal Cord Ser Cases

View full text Add to dashboard Cite

show abstract

“…Synchronous presentation of intracranial and extracranial melanocytomas is an exceedingly rare event with only few cases documented in the literature . Cases of synchronous or multifocal melanocytomas published in the English literature are summarized on Table …”

Section: Discussionmentioning

confidence: 99%

Subcutaneous melanocytoma mimicking a lipoma: a rare presentation of a rare neoplasm with histological, immunohistochemical, cytogenetic and molecular characterization

et al. 2016

View full text Add to dashboard Cite

Melanocytoma are the melanocytic tumors originating from leptomeningeal melanocytes. Melanocytomas are commonly seen in the central nervous system (CNS) and are often associated with neurocutaneous melanosis (NCM). However, simultaneous presentation of intra-axial and extracranial melanocytoma is a very rare event. Here, we report a unique case of 21-year-old male with intermediate-grade subcutaneous (SC) melanocytoma, mimicking lipoma, occurred synchronously with an intracranial melanocytoma, not associated with NCM. A 21-year-old Caucasian male presented to the emergency department (ED) with severe vertigo and vomiting. A magnetic resonance imaging (MRI) of the brain was performed at the ED, which revealed an SC mass in the right occipital scalp and a right cerebellopontine angle (CPA) mass. Excision of the SC mass revealed a well-circumscribed highly pigmented melanocytic tumor. The SC mass tumor cells were positive for melanocytic lineage markers. The histopathological features were between benign melanocytomas and malignant melanomas. The Ki67 and PHH3 IHCs confirm the intermediate grade of the tumors. An array-CGH (comparative genome hybridization) and next-generation sequencing analysis of the tumor DNA extracted from the formalin-fixed paraffin-embedded tissue reveals chromosome 6p gain and p.Q209P mutation in the GNAQ gene, respectively, consistent with the diagnosis of intermediate-grade melanocytoma.

show abstract

Multiple melanocytoma of the thoracic spine: a case report and literature review

Cited by 10 publications

References 4 publications

8-Year Follow-up for Woman with Spinal Meningeal Melanocytoma in S1 Nerve Root: Case Report and Literature Review

8-Year Follow-up for Woman with Spinal Meningeal Melanocytoma in S1 Nerve Root: Case Report and Literature Review

Multifocal primary melanoma of the cervical spinal cord successfully treated by tumorectomy: a case report

Subcutaneous melanocytoma mimicking a lipoma: a rare presentation of a rare neoplasm with histological, immunohistochemical, cytogenetic and molecular characterization

Contact Info

Product

Resources

About