Multiple mechanisms shape FM sweep rate selectivity: complementary or redundant?

Williams, Anthony; Fuzessery, Zoltan M.

doi:10.3389/fncir.2012.00054

Cited by 8 publications

(11 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The third observation is based on estimates of the timing of excitation and inhibition using tone bursts (Brimijoin and O’Neill, 2005; Razak and Fuzessery, 2009; Fuzessery et al, 2011; Williams et al, 2012). In this arrangement, an excitatory tone at the cell’s BF is presented while simultaneously presenting a tone in the inhibitory surround that suppresses the BF evoked spikes.…”

Section: 0 the Importance Of Frequency Modulations For Call Selectimentioning

confidence: 99%

“…One example is the formation of FM directional selectivity. In some IC neurons, directional selectivities are formed by the differences in timing of excitation and inhibition (Andoni et al, 2007; Fuzessery et al, 2011; Kuo et al, 2012; Pecka et al, 2007; Williams et al, 2012), whereas in other neurons timing is much less important. In those neurons the dominant features are the relative magnitudes and shapes of the excitatory and inhibitory conductances, which interact to create their directional selectivities (Gittelman et al, 2011; Gittelman et al, 2012; Gittelman, 2009).…”

Section: 0 Summary and Conclusionmentioning

confidence: 99%

See 1 more Smart Citation

The dominant role of inhibition in creating response selectivities for communication calls in the brainstem auditory system

Pollak

2013

Hearing Research

View full text Add to dashboard Cite

This review is concerned with how communication calls are processed and represented by populations of neurons in both the inferior colliculus (IC), the auditory midbrain nucleus, and the dorsal nucleus of the lateral lemniscus (DNLL), the nucleus just caudal to the IC. The review has five sections where focus in each section is on inhibition and its role in shaping response selectivity for communication calls. In the first section, the lack of response selectivity for calls in DNLL neurons is presented and discusses why inhibition plays virtually no role in shaping selectivity. In the second section, the lack of selectivity in the DNLL is contrasted with the high degree of response selectivity in the IC. The third section then reviews how inhibition in the IC shapes response selectivities for calls, and how those selectivities can create a population response with a distinctive response profile to a particular call, which differs from the population profile evoked by any other call. The fourth section is concerned with the specifics of inhibition in the IC, and how the interaction of excitation and inhibition creates directional selectivities for frequency modulations, one of the principal acoustic features of communication signals. The two major hypotheses for directional selectivity are presented. One is the timing hypothesis, which holds that the precise timing of excitation relative to inhibition is the feature that shapes directionality. The other hypothesis is that the relative magnitudes of excitation and inhibition are the dominant features that shape directionality, where timing is relatively unimportant. The final section then turns to the role of serotonin, a neuromodulator that can markedly change responses to calls in the IC. Serotonin provides a linkage between behavioral states and processing. This linkage is discussed in the final section together with the hypothesis that serotonin acts to enhances the contrast in the population responses to various calls over and above the distinctive population responses that were created by inhibition.

show abstract

Section: 0 the Importance Of Frequency Modulations For Call Selectimentioning

confidence: 99%

Section: 0 Summary and Conclusionmentioning

confidence: 99%

The dominant role of inhibition in creating response selectivities for communication calls in the brainstem auditory system

Pollak

2013

Hearing Research

View full text Add to dashboard Cite

show abstract

“…Selectivity for the rate of FM sweeps can also be created by the spectrotemporal interaction of inhibitory and excitatory inputs, but additional mechanisms are thought to play a role as well (Gordon and O'Neill, 1998; Fuzessery et al, 2006; Williams and Fuzessery, 2011, 2012). Much of the rate selectivity of inferior colliculus neurons appears to be already present in their synaptic inputs (Williams and Fuzessery, 2010, 2011; Gittelman and Li, 2011).…”

Section: Introductionmentioning

confidence: 99%

Intracellular responses to frequency modulated tones in the dorsal cortex of the mouse inferior colliculus

Geis¹,

Borst²

2013

Front. Neural Circuits

View full text Add to dashboard Cite

Frequency modulations occur in many natural sounds, including vocalizations. The neuronal response to frequency modulated (FM) stimuli has been studied extensively in different brain areas, with an emphasis on the auditory cortex and the central nucleus of the inferior colliculus. Here, we measured the responses to FM sweeps in whole-cell recordings from neurons in the dorsal cortex of the mouse inferior colliculus. Both up- and downward logarithmic FM sweeps were presented at two different speeds to both the ipsi- and the contralateral ear. Based on the number of action potentials that were fired, between 10 and 24% of cells were selective for rate or direction of the FM sweeps. A somewhat lower percentage of cells, 6–21%, showed selectivity based on EPSP size. To study the mechanisms underlying the generation of FM selectivity, we compared FM responses with responses to simple tones in the same cells. We found that if pairs of neurons responded in a similar way to simple tones, they generally also responded in a similar way to FM sweeps. Further evidence that FM selectivity can be generated within the dorsal cortex was obtained by reconstructing FM sweeps from the response to simple tones using three different models. In about half of the direction selective neurons the selectivity was generated by spectrally asymmetric synaptic inhibition. In addition, evidence for direction selectivity based on the timing of excitatory responses was also obtained in some cells. No clear evidence for the local generation of rate selectivity was obtained. We conclude that FM direction selectivity can be generated within the dorsal cortex of the mouse inferior colliculus by multiple mechanisms.

show abstract

“…Some of these neurons show selectivity to tone duration, FM or AM rate, and the delay between two tones. A number of hypotheses and theoretical models have attempted to explain the neuronal selectivity to these temporal features of sounds (Ehrlich et al, 1997 ; Covey and Casseday, 1999 ; Borisyuk et al, 2002 ; Large and Crawford, 2002 ; Nataraj and Wenstrup, 2005 ; Yin et al, 2008 ; Kuo and Wu, 2012 ; Williams and Fuzessery, 2012 ; Lee et al, 2019 ). Prominent inhibitory responses have been reported to present in dorsal IC neurons in awake animals in vivo (Xie et al, 2007 ; Wong and Borst, 2019 ) and are often associated with sound offset responses that have an essential role in duration encoding and discrimination (Sayegh et al, 2011 ; Kopp-Scheinpflug et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Developmentally Regulated Rebound Depolarization Enhances Spike Timing Precision in Auditory Midbrain Neurons

Sun

Zhang

Ross

et al. 2020

Front. Cell. Neurosci.

View full text Add to dashboard Cite

The inferior colliculus (IC) is an auditory midbrain structure involved in processing biologically important temporal features of sounds. The responses of IC neurons to these temporal features reflect an interaction of synaptic inputs and neuronal biophysical properties. One striking biophysical property of IC neurons is the rebound depolarization produced following membrane hyperpolarization. To understand how the rebound depolarization is involved in spike timing, we made whole-cell patch clamp recordings from IC neurons in brain slices of P9-21 rats. We found that the percentage of rebound neurons was developmentally regulated. The precision of the timing of the first spike on the rebound increased when the neuron was repetitively injected with a depolarizing current following membrane hyperpolarization. The average jitter of the first spikes was only 0.5 ms. The selective T-type Ca 2+ channel antagonist, mibefradil, significantly increased the jitter of the first spike of neurons in response to repetitive depolarization following membrane hyperpolarization. Furthermore, the rebound was potentiated by one to two preceding rebounds within a few hundred milliseconds. The first spike generated on the potentiated rebound was more precise than that on the non-potentiated rebound. With the addition of a calcium chelator, BAPTA, into the cell, the rebound potentiation no longer occurred, and the precision of the first spike on the rebound was not improved. These results suggest that the postinhibitory rebound mediated by T-type Ca 2+ channel promotes spike timing precision in IC neurons. The rebound potentiation and precise spikes may be induced by increases in intracellular calcium levels.

show abstract

Multiple mechanisms shape FM sweep rate selectivity: complementary or redundant?

Cited by 8 publications

References 60 publications

The dominant role of inhibition in creating response selectivities for communication calls in the brainstem auditory system

The dominant role of inhibition in creating response selectivities for communication calls in the brainstem auditory system

Intracellular responses to frequency modulated tones in the dorsal cortex of the mouse inferior colliculus

Developmentally Regulated Rebound Depolarization Enhances Spike Timing Precision in Auditory Midbrain Neurons

Contact Info

Product

Resources

About