Multiple Malignant Spiegler Tumors with Brachydactyly and Racket‐Nails

Tsambaos, D.; Greither, Aloys; Orfanos, Constantin E.

doi:10.1111/j.1600-0560.1979.tb00303.x

Cited by 30 publications

(6 citation statements)

References 9 publications

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“…Although cylindromas liave been classified as apocrine tumors on the basis of light-and electron-microscope sttidies (55)(56)(57)(58)(59)(60), other ultrastructural findings and immunohistochemical data have suggested tbe occurrence of eccrine differentiation in such tumors (9,11,12,43,(61)(62)(63)(64)(65). As in previous studies (5,9,11,12,43,61), several of the markers used in the present study indicated a clear link with eccrine glands; however, none of the markers that we applied is capable of distinguishing between eccrine and apocrine differentiation, bl luminal cells, CK 6 and CK 19 were predominant, while CEA and EMA were also detected, thus confiriTting and extending previous findings (11,12); however, one study (5) has reported the absence of simple-epithelial CKs (PKK 1 antibody) in luminal cells.…”

Section: Discussionmentioning

confidence: 99%

Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins

Demirkesen

Hoede²,

Moll³

1995

J Cutan Pathol

106

110

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Applying immunohistochemical procedures for the detection of eight different cytokeratin (CK) polypeptides and other differentiation markers, we compared the staining patterns of normal cutaneous structures with those of benign adnexal tumors (n = 65). Syringomas exhibited a marker pattern highly reminiscent of that seen in normal dermal eccrine ducts (EMA in peripheral cells, CK 10 in intermediate cells, and CK 6, CK 19, and CEA in luminal cells). Nodular hidradenomas exhibited complex patterns suggesting relationship between tumor cells, including clear cells, and normal secretory coil cells (CK 7, CK 8, CK 19, and EMA); however, dermal-duct and epidermoid differentiation were also detectable. In both cylindromas and spiradenomas, zonal staining patterns were apparent: modified myoepithelial cells were positive for smooth-muscle-type actin, while the luminal cells mainly expressed ductal markers (CK 6 and CK 19) and, less prominently, secretory-coil markers including CK 7. Eccrine poromas exhibited a widespread reaction for CK 5/6 and EMA, analogous to peripheral dermal duct cells, but focal maturation toward inner-ductal and secretory-coil cells was also demonstrable. The staining pattern observed in trichoepitheliomas resembled that of the outer but not the inner root sheath. In conclusion, the detailed marker profiles obtained in the present study have broadened our understanding of the differentiation and nature of these highly singular tumor types.

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Section: Discussionmentioning

confidence: 99%

Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins

Demirkesen

Hoede²,

Moll³

1995

J Cutan Pathol

106

110

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“…No follow-up information was given in 2 instances, Urbanski et al, have reviewed 9 previously reported cases with malignant transformation of cylindroma and added a case of their own with a large lesion of the scalp and underlying direct intracranial invasion. Most cases reported have been older individuals usually having multiple and longstanding lesions of the scalp (8)(9)(10)(11)(12)(13)(14)(15)(16), Multiple recurrences, lymph node involvement, and generalized metastasis have occurred in 7 cases (8),…”

Section: Commentsmentioning

confidence: 99%

Malignant transformation of eccrine tumors

1987

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Malignant transformation occurred in pre-existing sweat gland tumors in 7 patients. Three lesions showed an histologic pattern of eccrine spiradenoma, 2 eccrine poroma, one cylindroma and one papillary eccrine adenoma. Malignant transformation was histologically characterized by the presence of solid tumor areas populated with large cells having irregularly shaped nuclei and mitotic figures. There were multiple foci of squamous metaplasia, areas of loss of basement membrane and invasion of the surrounding connective tissue.

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“…They contain amorphous material that is composed of both acid and neutral mucopolysaccharides 7 . Instances of decapitation secretion by lumina cells have been described 9,10 …”

Section: Discussionmentioning

confidence: 99%