Multiple Malignancies of the Lung and Head and Neck

Lefor, Alan T.

doi:10.1001/archsurg.1986.01400030019001

Cited by 57 publications

(22 citation statements)

References 19 publications

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“…Our data, similar to what has been published previously, show that patients with solitary nodules and history of head and neck cancer are much more likely to have a primary lung cancer (64.4%) than metastasis (20%). 2,4 As reported by Quint et al 8 and Cahan,2 patients with head and neck carcinoma are much more likely to have a primary lung cancer than a solitary metastasis (ratio, 158:10 in the study by Cahan, 25:3 in the study by Quint, and 29:9 in our study). However, our study might have been biased toward malignant lesions, because we included only those patients who underwent CTguided biopsy.…”

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confidence: 77%

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Head and neck cancer patients with pulmonary nodules: Value and role of CT‐guided transthoracic needle aspiration biopsies

et al. 2003

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confidence: 77%

“…[1][2][3][4] We report our experience with transthoracic needle aspiration biopsies (TNAB) in 85 patients with head and neck cancer and pulmonary lesions. This study was undertaken to investigate the value and role of percutaneous biopsy in head and neck cancer patients with pulmonary lesions.…”

Section: Introductionmentioning

confidence: 99%

Head and neck cancer patients with pulmonary nodules: Value and role of CT‐guided transthoracic needle aspiration biopsies

et al. 2003

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“…Metastases to the tracheal are extremely There is a greater likelihood of developing multiple primary carcinomas in the same system than in unrelated rare. 1,19,23,24 …”

Section: Discussionmentioning

confidence: 99%

Primary malignant tumors of the trachea. A radiologic and clinical study

Ellerbroek

Libshitz

1990

Cancer

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Fifty-four cases (55 foci) of primary tracheal malignancies were reviewed retrospectively. Radiologic material was available in 32 cases (33 tracheal foci). The most frequent primary malignant tumor of the trachea was squamous cell carcinoma (54.5%), followed by adenoid cystic carcinoma (18%) and adenocarcinoma (9%). The radiologic appearance of the tumors could be divided into intraluminal, wall-thickening, and exophytic forms. Wall-thickening and exophytic forms in this study accounted for 62% of the tumors. This indicates that malignant tumors of the trachea tend to extraluminal invasion. Tomography and computed tomography are the most helpful methods of radiologic examination for tracheal tumors. Bronchoscopy and radiologic examination are complementary procedures. The chief advantage of imaging is the demonstration of tracheal wall thickening and extraluminal changes. Hemoptysis, dyspnea, and cough were the most common symptoms. Four cases (7%) in our series presented as thyroid tumors due to direct extension into the thyroid gland. Fifteen of the 54 cases (28%) were associated with other carcinomas of the head and neck and the lung.

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“…Lefor et al reported that median survival time (MST) when lung Death with head and neck carcinoma 5 metastases of head and neck cancer were left untreated was only 3 months, and that the 1-year survival rate was a disappointing 7 % [7]. Another recent study that used molecular-targeted drugs to treat recurrent and metastatic head and neck cancer reported an MST of 5.2-8.1 months, and a 1-year survival rate of 20-30 % [8].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Outcome After Resection of Pulmonary Metastasis from Head and Neck Carcinomas

Yamazaki

Shodo

Ueki

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Hematogenous metastasis is the most common form of metastasis in head and neck cancer, and reports have described successful resection of pulmonary metastases of such cancers. We report treatment outcomes after surgical resection of pulmonary metastases of head and neck cancer and identify prognostic factors. This clinicopathologic study investigated the clinical records of 16 patients with pulmonary metastases of head and neck cancer (excepting cases of thyroid cancer) who had undergone metastasectomy at our center during the period 2001-2012. The mean age of the 16 patients (11 men and 5 women) was 62.1 years. The mean interval between completion of successful treatment of the primary tumor and detection of pulmonary metastasis was 21 months (range, 6-56 months). All patients underwent pulmonary resection. The overall 1-year survival rate was 79.4 %, and the 2-to 5-year survival rate was 63.2 %. These rates compare favorably to those in previous reports on resection of pulmonary metastases. When prognostic factors for survival rates were compared, the factors associated with a negative prognosis were a disease-free interval of \12 months and partial resection of pulmonary metastases. Multivariate analysis did not reveal any prognostic factors associated with negative outcomes. Surgical resection of pulmonary metastases of head and neck cancer might improve outcomes.

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Multiple Malignancies of the Lung and Head and Neck

Cited by 57 publications

References 19 publications

Head and neck cancer patients with pulmonary nodules: Value and role of CT‐guided transthoracic needle aspiration biopsies

Head and neck cancer patients with pulmonary nodules: Value and role of CT‐guided transthoracic needle aspiration biopsies

Primary malignant tumors of the trachea. A radiologic and clinical study

Therapeutic Outcome After Resection of Pulmonary Metastasis from Head and Neck Carcinomas

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