Multiple lymphoid polyposis and familial polyposis of the colon

Venkitachalam, P. S.; Hirsch, Edward; Elguezabal, Alberto; Littman, Leon

doi:10.1007/bf02586662

Cited by 12 publications

(2 citation statements)

References 21 publications

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“…There was no Giardia lamblia infection in our data, and the reports on Giardia lamblia infection have been found mainly in the duodenum 23 , 24 . The terminal ileum associated with familial polyposis has been reported in some literature 16 , 25 - 27 . Peutz-Jeghers syndrome is characterized by multiple small polyps in the intestinal tract, but it has a high incidence of cancer.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and Ileocolonoscopic Characteristics in Patients with Nodular Lymphoid Hyperplasia in the Terminal Ileum

et al. 2017

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Nodular lymphoid hyperplasia (NLH) in the small intestine is a rare benign lesion, characterized by the presence of multiple small nodules on the surface of the intestine. To define the clinicopathological and colonoscopic characteristics in Chinese patients with ileal NLH, we collected 65 patients with NLH in the terminal ileum from the endoscopic database in our hospital and clinical data from medical records. Histology and immunohistochemical staining were performed in the biopsies. The results demonstrated that the main symptoms included diarrhea (70.8%), abdominal pain (60.0%), hematochezia (46.2%), anemia (40.0%), and hypoproteinemia (21.5%). Enteroscopy revealed multiple, sporadic, granular or round-shaped nodules with diameters between 2 and 5 mm in the terminal ileum. The histology revealed the nodules consisted of mass lymphoid follicles in the lamina propria and submucosa of the terminal ileum. The follicles contained mitotically active germinal centers surrounded by well-defined lymphocyte mantles and composed predominantly of CD20+ B cells. The diseases found in patients with NLH included chronic diarrhea, Crohn's disease, ischemic enterocolitis and allergic purpura. The level of hemoglobin in NLH patients who had diarrhea and hematochezia remarkably decreased as compared with those in patients with chronic diarrhea. In conclusion, ileocolonoscopic screening is an important step to find the NLH in terminal ileum patients with diarrhea, abdominal pain, hematochezia, and hypoproteinemia. Histological examination is necessary for the exclusion of malignancy and chronic inflammation.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological and Ileocolonoscopic Characteristics in Patients with Nodular Lymphoid Hyperplasia in the Terminal Ileum

et al. 2017

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“…NLH can mimic familial polyposis[19,20] and it has been reported in association with inflammatory bowel disease (IBD), celiac disease (CeD), lymphoma, dysgammaglobulinemia, Ehlers-Danlos syndrome, diversion colitis and food allergies[21-28]. …”

Section: Introductionmentioning

confidence: 99%

Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?

Piscaglia¹,

Laterza²,

Cesario³

et al. 2016

WJG

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AIMTo evaluate the prevalence of nodular lymphoid hyperplasia (NLH) in adult patients undergoing colonoscopy and its association with known diseases.METHODSWe selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome (IBS)-type symptoms or suspected inflammatory bowel disease (IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening. Data collection included medical history and final diagnosis. As controls, we considered all colonoscopies performed for the aforementioned indications during the same period.RESULTSOne thousand and one hundred fifty colonoscopies were selected. NLH was rare in asymptomatic individuals (only 3%), while it was significantly more prevalent in symptomatic cases (32%). Among organic conditions associated with NLH, the most frequent was IBD, followed by infections and diverticular disease. Interestingly, 31% of IBS patients presented diffuse colonic NLH. NLH cases shared some distinctive clinical features among IBS patients: they were younger, more often female, and had a higher frequency of abdominal pain, bloating, diarrhoea, unspecific inflammation, self-reported lactose intolerance and metal contact dermatitis.CONCLUSIONAbout 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients.

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Pathomorphologie

Otto¹

1982

Dickdarm

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Multiple lymphoid polyposis and familial polyposis of the colon

Cited by 12 publications

References 21 publications

Clinicopathological and Ileocolonoscopic Characteristics in Patients with Nodular Lymphoid Hyperplasia in the Terminal Ileum

Clinicopathological and Ileocolonoscopic Characteristics in Patients with Nodular Lymphoid Hyperplasia in the Terminal Ileum

Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?

Pathomorphologie

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