Multiple Lung Cancers Prognosis: What About Histology?

Riquet, Marc; Cazes, Aurélie; Pfeuty, Karel; Ngabou, Ulrich Davy; Foucault, Christophe; Dujon, Antoine; Banu, E.

doi:10.1016/j.athoracsur.2008.05.041

Cited by 87 publications

(71 citation statements)

References 22 publications

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“…The 2.4-fold increased growth rate of TR versus PT could explain the very efficient local control observed with irradiation, due to the higher radiosensitivity of TR compared to NP. The comparability of this concept to other tumors like prostate, colorectal or lung cancer should also be considered [27,76,87,90,99]. Clinical data and convincing clinical studies support the hypothesis that also positive lymph nodes and distant MET cannot metastasize.…”

Section: Consistency With the Clinical Picture Of Progressionmentioning

confidence: 86%

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True local recurrences do not metastasize

Hölzel

Emeny

Engel

2011

Cancer Metastasis Rev

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Generally, the limits of local tumor control are in part connected with the term "field cancerization" and are known from oral, lung, prostate, or mammary cancer. With the example of breast cancer (BC), the problem of ipsilateral breast tumor recurrences (IBTR) after breast-conserving surgery will be reviewed. Three types of local recurrences are distinguished: true recurrences, new primaries, or residual tumors. Good data for BC allow the description of the time-dependent risk of these three types, relative to the diagnosis of the primary tumor, because the time of initiation and the growth duration of the IBTR can be estimated. Two hypotheses explain the data: first, local recurrences may be initiated years before the diagnosis of a primary tumor (PT) and can then appear as multifocal PT at diagnosis, and second, true local recurrences probably do not metastasize. The generalizability of these hypotheses for other tumors will be discussed.

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Section: Consistency With the Clinical Picture Of Progressionmentioning

confidence: 86%

“…Foci near the PT and foci in different lobes can be monoclonal [89,90]. A possible explanation is, in addition to NP, a self-seeding process of the PT.…”

Section: Field Cancerizationmentioning

confidence: 99%

True local recurrences do not metastasize

Hölzel

Emeny

Engel

2011

Cancer Metastasis Rev

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“…Moreover, in cases of similar histology, histological sections from both FPLC and SPLC were compared. This approach may have contributed to a lower incidence of synchronous SPLC compared to others who described approximately one third of all SPLC patients as synchronous [21,22]. However, the histological pattern may have been changed in relapse tumours.…”

Section: Discussionmentioning

confidence: 71%

Characteristics and outcome of patients with second primary lung cancer

Reinmuth

Stumpf

et al. 2012

Eur Respir J

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Patients with lung cancer are at risk of developing a second primary lung cancer (SPLC). However, the characteristics of patients at risk remain largely speculative.We reviewed 2816 lung cancer patients from our institution for the occurrence of SPLC. Any SPLC was categorised as synchronous when diagnosed within 2 years of the first primary lung cancer (FPLC) and after direct histological comparison of both tumours. All other SPLCs were considered as metachronous.139 patients developed a second malignancy including 69 nonsmall cell lung cancer (NSCLC) and 9 small cell lung cancer. The median interval for diagnosis of metachronous SPLC (n559) after FPLC occurrence was 72 months. SPLC detected within 5 years of FPLC diagnosis had a more favourable stage distribution (p50.02). After diagnosis of SPLC, patients had a superior median overall survival compared to controls (57.7 versus 18.1 months; p,0.0001). Interestingly, comparing only stage IV NSCLC patients, a history of FPLC was also associated with a favourable survival (median 27.4 versus 8.97 months; p50.007).In summary, previous lung cancer treatment does not lead to impaired prognosis after diagnosis of SPLC. Improved surveillance programmes beyond 5 years after FPLC treatment may result in more favourable disease stages for detected SPLC. @ERSpublications Previous lung cancer treatment does not lead to impaired prognosis after diagnosis of secondary primary lung cancer

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“…A study with a larger number of patients published by Trousse et al reported 3-and 5-year survival at a rate of 48% and 34%, respectively [11]. Riquet et al reported 3-and 5-year survival at a rate of 40% and 26%, respectively [12]. Patients with SMPLC in a study by Finley et al with stages IA and IB who were surgically treated have a 74% and 65% 3-year overall survival, respectively [9].…”

Section: Discussionmentioning

confidence: 99%

Primary synchronous small and non-small cell lung cancer in the same lung lobe: A case report

Dzian

Fučela

Huťka

et al. 2017

Monaldi Arch Chest Dis

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Synchronous multiple primary lung cancer (SMPLC) means tumours present at the same time, which are separate and have different histology. We present the case of a 66-year-old patient with a combination of small-cell lung carcinoma (SCLC) with adenocarcinoma in the same lobe with metastasis of SCLC in the mediastinal lymph node. This is a rare case. We performed a standard left upper video-assisted thoracoscopic lobectomy with mediastinal lymphadenectomy and adjuvant therapy targeted to SCLC was administered. Despite advances in imaging methods and diagnostic procedures in pneumology a diagnosis of SMPLC is often discovered only intraoperatively or accidentally during the histological examination. Actually, no guidelines exist for the treatment protocol of such cases. Multiple methods of management of SMPLC, mainly complete anatomical resection with lymphadenectomy combined with chemotherapy or radiotherapy should be adopted according to the histologic types, staging and molecular testing of the tumours. These rare cases of SMPLC require individual treatment and multidisciplinary approach.

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Multiple Lung Cancers Prognosis: What About Histology?

Cited by 87 publications

References 22 publications

True local recurrences do not metastasize

True local recurrences do not metastasize

Characteristics and outcome of patients with second primary lung cancer

Primary synchronous small and non-small cell lung cancer in the same lung lobe: A case report

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