Multiple Listeria Abscesses in an Immunocompetent Patient

Frade, Heitor C; Pingili, Chandra Shekar; Nattanamai, Premkumar

doi:10.7759/cureus.6642

Cited by 4 publications

(6 citation statements)

References 14 publications

(19 reference statements)

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“…39 TMP-SMX is recommended for those allergic to penicillin. 37,39 The combination of ampicillin and TMP-SMX has previously been described as an effective treatment for CNS listeriosis. 39,44 In 1 retrospective series, therapy with TMP-SMX plus ampicillin was correlated with a lower failure and fewer neurologic sequelae than ampicillin combined with an aminoglycoside.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis is even worse in brain abscesses caused by L. monocytogenes infection with a mortality rate as high as 50%, 12,17,25,26,29,33 and this mortality is higher than in patients with nonlisterial abscesses. 37 The poor prognosis of SLE patients with L. monocytogenes infections suggests that more attention should be given to this topic in clinical practice.…”

Section: Three Of the 4 Cases Of Multiple Brain Abscesses In Sle Reportedmentioning

confidence: 99%

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Multiple brain abscesses due to Listeria monocytogenes infection in a patient with systemic lupus erythematosus: A case report and literature review

et al. 2021

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Systemic lupus erythematosus (SLE) is a condition in which the immune system attacks healthy cells and tissues throughout the body, and infection is one of the most common causes of death in patients with SLE. 1 SLE patients are highly susceptible to infections as a result of disease-related immunological dysfunction itself or immunosuppressive treatments. A systematic review and meta-analysis showed that the pooled relative risks (RRs) for overall severe infection are significantly higher in patients with SLE than in the general

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Section: Discussionmentioning

confidence: 99%

Section: Three Of the 4 Cases Of Multiple Brain Abscesses In Sle Reportedmentioning

confidence: 99%

Multiple brain abscesses due to Listeria monocytogenes infection in a patient with systemic lupus erythematosus: A case report and literature review

et al. 2021

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“…Brain abscess is a rare manifestation of Listeria monocytogenes with approximately 80 cases described in literature. [4][5][6] Listeria brain abscesses are characteristically located in the sub-cortical grey matter especially in basal ganglia, thalamus or pons. 4,7 Apart from its sub-cortical location, the diagnosis is usually based on a positive blood culture yielding Listeria monocytogenes which may be positive in up to 85% of cases.…”

Section: Discussionmentioning

confidence: 99%

Listeria monocytogenes brain abscess in an immunocompromised patient: a case report

et al. 2020

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Listeria monocytogenes is a facultative intracellular gram-positive bacillus which usually infects immunocompromised patients, though it can infrequently infect immunocompetent individuals, neonates and pregnant women as well. Neurological manifestations include meningitis and cerebritis. Brain Abscess is an extremely rare presentation with approximately 80 reported cases. Authors report a patient with a brain abscess identified on an MRI scan with positive blood culture for Listeria monocytogenes. Patient was managed conservatively with intravenous followed by oral antibiotics with resolution of the abscess.

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“…As such, a young immunocompetent patient with LM infection is extremely uncommon 4,5 . Although rare, LM should be considered in all cases of rhombencephalitis, as it represents the most common infective cause of this, and has been reported in immunocompetent patients as well [4][5][6][7] . Despite adequate antimicrobial treatment Listeriosis has an average case fatality of 23-30% 2 .…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Although rare, LM should be considered in all cases of rhombencephalitis, as it represents the most common infective cause of this, and has been reported in immunocompetent patients as well. [4][5][6][7] Despite adequate antimicrobial treatment listeriosis has an average case fatality of 23 to 30%. 2 In this case, we report a unique presentation of LM infection in a fit and healthy 37-year-old whose condition rapidly deteriorated leading to respiratory failure requiring intubation, mandatory mechanical ventilation, and prolonged intensive care unit (ICU) admission.…”

Section: Introductionmentioning

confidence: 99%

A Case of Fulminant Listeria Rhombencephalitis with Brainstem Abscesses in a 37-Year-Old Immunocompetent Patient: From Vestibular Neuritis to Ondine's Curse

Percuoco

Kemp

Bolognese

et al. 2022

J Neurol Surg A Cent Eur Neurosurg

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We present a rare case of Listeria monocytogenes (LM) rhombencephalitis with formation of multifocal abscesses in a young immunocompetent patient. His initial symptoms of dizziness, headache, and feeling generally unwell were put down to a coincidental co-infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The unfortunate rapid progression to trigeminal, hypoglossal, vagal, facial, and abducens nuclei palsies, and then an acquired central hypoventilation syndrome, known as Ondine’s curse, required a prolonged intensive care unit (ICU) stay, and prolonged mechanical ventilation. As they continued to deteriorate despite targeted antibiotic treatment, surgical drainage of the abscesses was seen as the only meaningful available treatment option left to contain the disease. Postoperatively, the patient’s strength rapidly improved as well as the severity of the cranial nerve palsies. After prolonged rehabilitation, at three months follow up the patient was weaned off mechanical ventilation, independently mobile, and was left with only minor residual neurological deficits. This case highlights a number of interesting findings only touched upon in current literature including, route of entry of LM into the central nervous system, the rare entity of acquired central hypoventilation syndrome, and lastly the use of surgical intervention in cerebral LM infections.

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Multiple Listeria Abscesses in an Immunocompetent Patient

Cited by 4 publications

References 14 publications

Multiple brain abscesses due to Listeria monocytogenes infection in a patient with systemic lupus erythematosus: A case report and literature review

Multiple brain abscesses due to Listeria monocytogenes infection in a patient with systemic lupus erythematosus: A case report and literature review

Listeria monocytogenes brain abscess in an immunocompromised patient: a case report

A Case of Fulminant Listeria Rhombencephalitis with Brainstem Abscesses in a 37-Year-Old Immunocompetent Patient: From Vestibular Neuritis to Ondine's Curse

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