Multiple-layer guided surface acoustic wave (SAW)-based pH sensing in longitudinal FiSS-tumoroid cultures

Wang, Tao; Green, Ryan; Guldiken, Rasim; Mohapatra, Subhra; Mohapatra, Shyam S.

doi:10.1016/j.bios.2018.10.011

Cited by 16 publications

(20 citation statements)

References 48 publications

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“…As shown in Figure 6a, the simulated frequency characteristic did show a good match with the experimental data in the previous research [35]. In Figure 6 and Figure 7, we show that as the IrO 2 layer increased, the insertion loss decreased.…”

Section: Resultssupporting

confidence: 83%

“…A piezoelectric layer with a relatively high permittivity added on top of the piezoelectric layer (Lithium Titanate) increases the electromechanical coupling, thus allowing fabrication of devices with reduced insertion loss [37]. After the ZnO waveguide layer was deposited on top of the surface of the Lithium Tantalite substrate, a layer of IrO 2 was deposited on top of the ZnO layer to further increase the sensitivity [35]. The dielectric properties of different guide layers will also affect the wave properties in a different fashion.…”

Section: Resultsmentioning

confidence: 99%

“…The first layer of the device was the chrome IDT fingers with a thickness of 100 nm, the second layer was the waveguide layer made of 500 nm-thick ZnO, and the top layer was the IrO 2 layer as seen in the fabricated device in Figure 1c. The layer’s properties and fabrication process are shown in our previous report [35].…”

Section: Experiments and Methodsmentioning

confidence: 99%

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Finite Element Analysis for Surface Acoustic Wave Device Characteristic Properties and Sensitivity

Wang

Green

Guldiken

et al. 2019

Sensors

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The most vital step in the development of novel and existing surface acoustic wave (SAW)-based sensors and transducers is their design and optimization. Demand for SAW devices has been steadily increasing due to their low cost, portability, and versatility in electronics, telecommunications, and biosensor applications. However, a full characterization of surface acoustic wave biosensors in a three-dimensional (3D) finite element model has not yet been developed. In this study, a novel approach is developed for analyzing shear horizontal Love wave resonator devices. The developed modeling methodology was verified using fabricated devices. A thorough analysis of the 3D model and the experimental device was performed in this study including scattering parameters (S-parameters), reflection coefficient parameters, transmission parameters, and phase velocity. The simulated results will be used as a design guideline for future device design and optimization, which has thus far resulted in close matching between prediction and experimental results. This manuscript is the first to demonstrate a 3D finite element model to correlate the sensitivity of the SAW device with the magnitude of the phase shift, the real and imaginary part of the response, insertion loss, and the frequency shift. The results show that the imaginary part of the response shift has a higher sensitivity compared to other parameters.

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Section: Resultssupporting

confidence: 83%

Section: Resultsmentioning

confidence: 99%

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Finite Element Analysis for Surface Acoustic Wave Device Characteristic Properties and Sensitivity

Wang

Green

Guldiken

et al. 2019

Sensors

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“…To overcome these challenges, an optimized surface acoustic wave (SAW)-based multiple-layer sensor and passive electrode potential sensor was integrated with microfluidic 96-well plates and fabricated by traditional microfabrication techniques. Full optimization of the sensor settings and the flow rate was conducted by finite element analysis to increase the sensitivity and generate appropriate shear stress on cells [63][64][65][66]. It was found that a fiber inspired smart scaffold (FiSS) platform established in the Mohapatra laboratory allows for the growth of 3D tumor-like aggregates (tumoroids), which resemble in vivo tumors [67].…”

Section: Tissue Engineeringmentioning

confidence: 99%

Advances in Translational Nanotechnology: Challenges and Opportunities

et al. 2020

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The burgeoning field of nanotechnology aims to create and deploy nanoscale structures, devices, and systems with novel, size-dependent properties and functions. The nanotechnology revolution has sparked radically new technologies and strategies across all scientific disciplines, with nanotechnology now applied to virtually every area of research and development in the US and globally. NanoFlorida was founded to create a forum for scientific exchange, promote networking among nanoscientists, encourage collaborative research efforts across institutions, forge strong industry-academia partnerships in nanoscience, and showcase the contributions of students and trainees in nanotechnology fields. The 2019 NanoFlorida International Conference expanded this vision to emphasize national and international participation, with a focus on advances made in translating nanotechnology. This review highlights notable research in the areas of engineering especially in optics, photonics and plasmonics and electronics; biomedical devices, nano-biotechnology, nanotherapeutics including both experimental nanotherapies and nanovaccines; nano-diagnostics and -theranostics; nano-enabled drug discovery platforms; tissue engineering, bioprinting, and environmental nanotechnology, as well as challenges and directions for future research.

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“…[5][6][7][8] In some of these applications, the lm surface of the SAW devices needs to be in direct contact with the targeted objects during either sensing or microuidic processes. For example, when the SAW device is used to detect hydrogen uoride, hydrochloric acid, uric acid detection and pH value [9][10][11] or is used as an actuator for a lab-on-chip in a biochemical environment, the SAW device will be exposed to an acid/alkali harsh environment. Therefore, the quick failure of lm based acoustic wave devices caused by chemical reactions oen becomes a critical issue.…”

Section: Introductionmentioning

confidence: 99%

Stability studies of ZnO and AlN thin film acoustic wave devices in acid and alkali harsh environments

Xiong

Zhou

et al. 2020

RSC Adv.

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Multiple-layer guided surface acoustic wave (SAW)-based pH sensing in longitudinal FiSS-tumoroid cultures

Cited by 16 publications

References 48 publications

Finite Element Analysis for Surface Acoustic Wave Device Characteristic Properties and Sensitivity

Finite Element Analysis for Surface Acoustic Wave Device Characteristic Properties and Sensitivity

Advances in Translational Nanotechnology: Challenges and Opportunities

Stability studies of ZnO and AlN thin film acoustic wave devices in acid and alkali harsh environments

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