Multiple Keratoacanthoma

Intralesional Corticosteroid Treatment of Multiple Eruptive Keratoacanthomas: Case Report and Review of a Controversial Therapy

“…It is paradoxical that immunosuppressive corticosteroids cause regression of keratoacanthomas, since regression of keratocanthomas may be immune mediated 31 and keratoacanthomas are probably more common in immunosuppressed hosts 32 . In fact, in 1958 it was reported that systemic cortisone failed to treat multiple keratoacanthomas, 33 although intramuscular triamcinolone and methotrexate were subsequently reported to successfully treat a keratoacanthoma 34 . Studies of systemic corticosteroid administration in animals with experimental papillomas have yielded conflicting results 35 …”