Multiple-jet electrospinning methods for nanofiber processing: A review

SalehHudin, Hanna Sofia; Mohamad, Edzrol Niza; Mahadi, Wan Nor Liza Binti Wan; Afifi, Amalina M.

doi:10.1080/10426914.2017.1388523

Cited by 178 publications

(128 citation statements)

References 141 publications

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“…In the medical and pharmaceutical fields the need for novel nanofiber designs that include hollow, porous, multichannel tubular, shape of necklace, core-sheath, nanowebs, nanowire, multilayer structures, among others, has increased considerably over the years since these new architectures respond better to certain applications [38,[44][45][46]. By combining new electrostatic and magnetic strategies to the electrospinning technique, advances have been made towards the production of aligned, spiral, tubular and sheath membranes that respond to specific demands in TE [8].…”

Section: Electrospinning In the Production Of Nanofibrous Scaffoldsmentioning

confidence: 99%

“…Typically, there are two types of electrospinning setups: horizontal and vertical (upward and downward) as depicted in Figure 1 [46]. However, this process is very time consuming, limiting the potential large-scale application of the resulting products [44]. The production rate of a conventional electrospinning system is less than 10 g h −1 of nanofibers, depending on polymer concentration and operating conditions [49].…”

Section: Electrospinning In the Production Of Nanofibrous Scaffoldsmentioning

confidence: 99%

“…A simple approach to enhance the production rate of nanofibers was developed by increasing the number of nozzles used, which includes not only needles but also tips, holes and channels. This approach is known as multiple-jet electrospinning and can be classified into (i) a single nozzle with multiple jets, (ii) multiple nozzles with a single jet exiting from each nozzle or (iii) multiple nozzles with multiple jets exiting from each nozzle [44]. The multiple-jet electrospinning overcomes the drawbacks of single jet spinning in terms of productivity and offers the potential for mass production by means of a simple and versatile setup, with greater control of fiber distribution [41].…”

Section: Composition Natural (Nt)mentioning

confidence: 99%

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Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.

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Section: Electrospinning In the Production Of Nanofibrous Scaffoldsmentioning

confidence: 99%

Section: Electrospinning In the Production Of Nanofibrous Scaffoldsmentioning

confidence: 99%

Section: Composition Natural (Nt)mentioning

confidence: 99%

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Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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“…Each spinneret design has its advantages and disadvantages-wires, discs and cylinders spinnerets generally increase productivity, but require very high voltage and form uneven Taylor cone resulting in production of uneven fibers. In the case of free surface electrospinning, various spinning parameters are poorly controlled 54 . The PMES method developed provides solutions to those issues and could be very much suitable to produce nanoparticle encapsulated electrospun mat to enhance the functional applications of nanofibers.…”

Section: Resultsmentioning

confidence: 99%

A Novel Profiled Multi-Pin Electrospinning System for Nanofiber Production and Encapsulation of Nanoparticles into Nanofibers

Prabu

Dhurai²

2020

Sci Rep

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Electrospinning with various machine configurations is being used to produce polymer nanofibers with different rates of output. The use of polymers with high viscosity and the encapsulation of nanoparticles for achieving functionalities are some of the limitations of the existing methods. A profiled multi-pin electrospinning (PMES) setup is demonstrated in this work that overcomes the limitations in the needle and needleless electrospinning like needle clogging, particle settling, and uncontrolled/uneven Taylor cone formation, the requirement of very high voltage and uncontrolled distribution of nanoparticles in nanofibers. The key feature of the current setup is the use of profiled pin arrangement that aids in the formation of spherical shape polymer droplet and hence ensures uniform Taylor cone formation throughout the fiber production process. With a 10 wt% of Polyvinyl Alcohol (PVA) polymer solution and at an applied voltage of 30 kV, the production rate was observed as 1.690 g/h and average fiber diameter obtained was 160.5 ± 48.9 nm for PVA and 124.9 ± 49.8 nm for Cellulose acetate (CA) respectively. Moreover, the setup also provides the added advantage of using high viscosity polymer solutions in electrospinning. This approach is expected to increase the range of multifunctional electrospun nanofiber applications.

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“…Due to their advantages of small diameter, high porosity and large specific surface area, electrospun nanofibers have been widely used in various fields like energy sensing, air filtration, water treatment and biomedicine [1][2][3][4]. However, the low productivity of traditional single-nozzle spinnerets limits the further extension of electrospinning technology [5,6].…”

Section: Introductionmentioning

confidence: 99%

Arced Multi-Nozzle Electrospinning Spinneret for High-Throughput Production of Nanofibers

et al. 2019

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The stable and continuous ejection of multiple jets with high densities is the key to the application of electrospinning technology. An arced multi-nozzle spinneret was designed to increase the production efficiency of electrospinning. The distribution of the electrical field was simulated to optimize the nozzles’ distribution of the spinneret. When the nozzles were arranged in an arc array, a relatively uniform electrical field could be obtained, which was beneficial for the weakening of electrical interference among the nozzles. Under the optimized electrical field, multiple jets from each nozzle could be ejected in a stable and continuous way. With the increase of the applied voltage, the electrical stretching force became larger, and there were fewer bonding structures. The average diameter of the electrospun nanofibers decreased with the increase of the applied voltage. When the distance between the inner nozzle and the collector increased, the charged jets suffered a larger stretching effect, resulting in the decrease of the average diameter of the electrospun nanofibers. The electrospinning current increased with the applied voltage and decreased with the distance between the inner nozzle and the collector, which is an important aspect for the monitoring of electrospinning jets. This work provides an effective way to promote the production efficiency of electrospun nanofibrous membranes.

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Multiple-jet electrospinning methods for nanofiber processing: A review

Cited by 178 publications

References 141 publications

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

A Novel Profiled Multi-Pin Electrospinning System for Nanofiber Production and Encapsulation of Nanoparticles into Nanofibers

Arced Multi-Nozzle Electrospinning Spinneret for High-Throughput Production of Nanofibers

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